PTSDgene database

Pathway Enrichment Analysis Protein-Protein Interaction Analysis

Study Report

Study Information

Basic Info

Reference	Cao, C.,2014 PMID: 25014617
Citation	Cao, C., et al. (2014). "TPH2 genotype is associated with PTSD's avoidance symptoms in Chinese female earthquake survivors." Psychiatr Genet 24(6): 257-261.
Phenotype	PTSD symptoms, Reexperiencing symptoms, Avoidance symptoms, Emotional numbing symptoms, Dsyphoric arousal symptoms, Anxious arousal symptoms
Trauma	Lost their children during the 2008 Wenchuan earthquake.
Study Design	Cross-sectional study
Study Type	Candidate gene association study
Sample Size	309 samples
SNP/Marker Size	1 SNP
Predominant Ethnicity	Mongloid
Population	140 (45.3%) participants were self-reported as Han nationality, 162 (52.4%) were Qiang nationality, and 7 (2.3%) belonged to other subnationalities in China.
Gender	217 females, 92 males
Age	Mean age=44.73 years, SD=11.5

Detail Info

Genetic result reported by this study

Normal genetic result reported by this study (count: 6)

Marker	Phenotype	Related Gene	Statistical Values	Author Comments	Marker's Category
rs11178997	Avoidance symptoms	TPH2	In total sample: t=0.422, P-value=0.039, in females: t=2.765, P-value=0.006, in males: t=-0.364, P-value=0.717.	The rs11178997 'TT' genotype was significantly associated wi...... The rs11178997 'TT' genotype was significantly associated with avoidance symptoms in women but not in men. More...	Significant
rs11178997	PTSD symptoms	TPH2	In total sample: t=0.082, P-value=0.133, in females: t=1.807, P-value=0.072, in males: t=0.128, P-value=0.899.	No significant relationship. No significant relationship.	Non-significant
rs11178997	Emotional numbing symptoms	TPH2	In total sample: t=1.860, P-value=0.023, in females: t=2.518, P-value=0.013, in males: t=0.539, P-value=0.592.	No significant relationship. No significant relationship.	Non-significant
rs11178997	Anxious arousal symptoms	TPH2	In total sample: t=-0.633, P-value=0.627, in females: t=0.544, P-value=0.587, in males: t=0.122, P-value=0.903.	No significant relationship. No significant relationship.	Non-significant
rs11178997	Reexperiencing symptoms	TPH2	In total sample: t=-1.099, P-value=0.417, in females: t=1.231, P-value=0.220, in males: t=-0.304, P-value=0.762.	No significant relationship. No significant relationship.	Non-significant
rs11178997	Dysphoric arousal symptoms	TPH2	In total sample: t=-0.406, P-value=0.642, in females: t=0.210, P-value=0.834, in males: t=0.414, P-value=0.680.	No significant relationship. No significant relationship.	Non-significant