PTSDgene database

SNP Report

Basic Info
Name rs1386494 dbSNP Ensembl
Location 12:71958763 - 71958763(+)
Variant Seq C
Ancestral Allele T
Ref Seq T
Minor Allele Frequence 0.143171
Annotation intron_variant; non_coding_transcript_variant
Variant Effect intron_variant(ENST00000546576, ENST00000333850); non_coding_transcript_variant(ENST00000546576)
SIFT Annotation tolerated
SIFT Variant Effect tolerated(ENST00000333850)
PolyPhen Annotation benign
PolyPhen Variant Effect benign(ENST00000333850)
rSNP? Yes Link in rVarBase
Related Regulatory Elements n/a
Chromatin State Enhancers;Flanking Active TSS
No. of Marker's Association Results 1 (Positive: 0; Negative: 1; Trend: 0)
Source Literature

SNP related association results
Normal genetic study related association results (count: 1)
Reference Phenotype Statistical Values Author Comments Marker's Category
Goenjian, A. K.,2012 PTSD-RI (PTSD symptoms) After adjusting for age, sex, exposure and environmental var...... After adjusting for age, sex, exposure and environmental variables, analyses of PTSD-RI and this SNP: P-value>0.05. More... The remainder of the TPH2 SNPs tested did not show a signifi...... The remainder of the TPH2 SNPs tested did not show a significant association with PTSD-RI scores; and the linkage scores were below 1.0. More... Non-significant


SNP related genes (count: 1)
Approved Symbol Approved Name Location No. of Association Results (Positive/Negative/Trend)
TPH2 tryptophan hydroxylase 2 12q15 10(3/7/0)

SNPs in LD with rs1386494 (count: 33)
The LD data used here is based on 1000 Genome Phase I. LD SNP pairs were selected with a threshold r2<=0.8.

Literature-origin SNPs (count: 0)

LD-proxies (count: 33)


SNP related eQTL (count: 1)
Gene Symbol Gene Existed in PTSDgene? Tissue Trans/Cis Source
RP11-707O23.5 No Adipose Subcutaneous cis GTEx