SNP Report
Basic Info
| Name | rs4290270 dbSNP Ensembl | ||
|---|---|---|---|
| Location | 12:72022455 - 72022455(+) | ||
| Variant Seq | T | ||
| Ancestral Allele | A | ||
| Ref Seq | A | ||
| Minor Allele Frequence | 0.48722 | ||
| Annotation | synonymous_variant | ||
| Variant Effect | synonymous_variant(ENST00000333850) | ||
| SIFT Annotation | tolerated | ||
| SIFT Variant Effect | tolerated(ENST00000333850) | ||
| PolyPhen Annotation | benign | ||
| PolyPhen Variant Effect | benign(ENST00000333850) | ||
| rSNP? | Yes Link in rVarBase | ||
| Related Regulatory Elements | n/a | ||
| Chromatin State | Weak transcription;Enhancers | ||
| No. of Marker's Association Results | 1 (Positive: 0; Negative: 1; Trend: 0) | ||
| Source | Literature | ||
SNP related association results
| Reference | Phenotype | Statistical Values | Author Comments | Marker's Category |
|---|---|---|---|---|
| Goenjian, A. K.,2012 | PTSD-RI (PTSD symptoms) | After adjusting for age, sex, exposure and environmental var...... After adjusting for age, sex, exposure and environmental variables, analyses of PTSD-RI and this SNP: P-value>0.05. More... | The remainder of the TPH2 SNPs tested did not show a signifi...... The remainder of the TPH2 SNPs tested did not show a significant association with PTSD-RI scores; and the linkage scores were below 1.0. More... | Non-significant |
SNP related genes (count: 1)
| Approved Symbol | Approved Name | Location | No. of Association Results (Positive/Negative/Trend)  |
|---|---|---|---|
| TPH2 | tryptophan hydroxylase 2 | 12q15 | 10(3/7/0) |
SNPs in LD with rs4290270 (count: 28)
Literature-origin SNPs (count: 0)
LD-proxies (count: 28)
SNP related eQTL (count: 1)