Gene Report

Basic Info

Approved Symbol	CAV3
Symbol Alias	"VIP-21\|LGMD1C\|VIP21\|LQT9"
Approved Name	caveolin 3
Name Alias	M-caveolin
Location	3p25
Position	chr3:8733800-8841808, 1
External Links	HGNC: 1529 Entrez Gene: 859 Ensembl: ENSG00000182533 UCSC: uc003brb.3
No. of Association Results	0. Gene is from "Mapped by Literature SNP, Mapped by LD-proxy"
Annotation Type	Mapped by Literature SNP, Mapped by LD-proxy

Gene functional annotation

Gene related GO terms (count: 87)

ID	Name	Type	Evidence[PMID]	No. of Genes in PTSDgene
GO:0055117	regulation of cardiac muscle contraction	biological process	IMP[17275750]	2
GO:0005515	protein binding	molecular function	IPI[10988290\|25556234]	169
GO:0032947	protein complex scaffold	molecular function	IPI[17060380]; ISS	2
GO:0055013	cardiac muscle cell development	biological process	IEA	1
GO:0042632	cholesterol homeostasis	biological process	ISS	8
GO:0014704	intercalated disc	cellular component	IEA	2
GO:2001288	positive regulation of caveolin-mediated endocytosis	biological process	IEA	1
GO:1901019	regulation of calcium ion transmembrane transporter activity	biological process	IDA[21084288]	1
GO:0031982	vesicle	cellular component	IEA	7
GO:0061052	negative regulation of cell growth involved in cardiac muscle cell development	biological process	IEA	1
GO:0030018	Z disc	cellular component	ISS	4
GO:0031594	neuromuscular junction	cellular component	ISS	1
GO:1900744	regulation of p38MAPK cascade	biological process	IEA	1
GO:0051647	nucleus localization	biological process	IEA	1
GO:1900826	negative regulation of membrane depolarization during cardiac muscle cell action potential	biological process	IEA	1
GO:0006936	muscle contraction	biological process	TAS	3
GO:0032403	protein complex binding	molecular function	IDA[10988290]	8
GO:0007517	muscle organ development	biological process	TAS[10988290]	1
GO:0010831	positive regulation of myotube differentiation	biological process	IEA	1
GO:0038009	regulation of signal transduction by receptor internalization	biological process	IMP[20472890]	1
GO:1900825	regulation of membrane depolarization during cardiac muscle cell action potential	biological process	IMP[17275750]	1
GO:0045121	membrane raft	cellular component	ISS	7
GO:0043409	negative regulation of MAPK cascade	biological process	ISS	1
GO:0060373	regulation of ventricular cardiac muscle cell membrane depolarization	biological process	IDA[17060380]	1
GO:0005829	cytosol	cellular component	IEA	78
GO:0043231	intracellular membrane-bounded organelle	cellular component	IDA	9
GO:0005246	calcium channel regulator activity	molecular function	IDA[21084288]	4
GO:0060347	heart trabecula formation	biological process	IEA	1
GO:2000009	negative regulation of protein localization to cell surface	biological process	NAS[22879586]	1
GO:0030315	T-tubule	cellular component	ISS	5
GO:0017080	sodium channel regulator activity	molecular function	IDA[17060380]; IMP[17275750]	2
GO:0007015	actin filament organization	biological process	IEA	3
GO:0005886	plasma membrane	cellular component	IDA[17060380\|20472890]; TAS	99
GO:0031579	membrane raft organization	biological process	ISS	1
GO:0070836	caveola assembly	biological process	IDA[18936328]	1
GO:0043407	negative regulation of MAP kinase activity	biological process	IMP[12847114]	4
GO:0008104	protein localization	biological process	ISS	4
GO:0035995	detection of muscle stretch	biological process	IEA	1
GO:0090002	establishment of protein localization to plasma membrane	biological process	IEA	2
GO:0031116	positive regulation of microtubule polymerization	biological process	ISS	3
GO:0008284	positive regulation of cell proliferation	biological process	IEA	14
GO:0042593	glucose homeostasis	biological process	ISS	7
GO:0007520	myoblast fusion	biological process	IEA	3
GO:0006641	triglyceride metabolic process	biological process	ISS	6
GO:0072659	protein localization to plasma membrane	biological process	ISS	3
GO:0033292	T-tubule organization	biological process	TAS[12847114]	1
GO:2000060	positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process	biological process	NAS[22879586]	2
GO:0060307	regulation of ventricular cardiac muscle cell membrane repolarization	biological process	IMP[17060380]	2
GO:0014819	regulation of skeletal muscle contraction	biological process	IMP[17524427]	1
GO:0042383	sarcolemma	cellular component	IDA[12847114\|17060380]	7
GO:0005901	caveola	cellular component	IEA	7
GO:0000139	Golgi membrane	cellular component	IEA	12
GO:0001778	plasma membrane repair	biological process	IEA	1
GO:0019870	potassium channel inhibitor activity	molecular function	ISS[22879586]	1
GO:0007009	plasma membrane organization	biological process	ISS	3
GO:0051896	regulation of protein kinase B signaling	biological process	IEA	1
GO:0008016	regulation of heart contraction	biological process	ISS	2
GO:0051394	regulation of nerve growth factor receptor activity	biological process	IMP[20472890]	1
GO:0051001	negative regulation of nitric-oxide synthase activity	biological process	ISS	2
GO:0009986	cell surface	cellular component	IEA	21
GO:0006897	endocytosis	biological process	ISS	3
GO:0060299	negative regulation of sarcomere organization	biological process	IMP[12847114]	1
GO:0086005	ventricular cardiac muscle cell action potential	biological process	ISS[22879586]	1
GO:2000649	regulation of sodium ion transmembrane transporter activity	biological process	IDA[17060380\|17275750]	1
GO:0007204	positive regulation of cytosolic calcium ion concentration	biological process	ISS	7
GO:0045792	negative regulation of cell size	biological process	IMP[12847114]	1
GO:0008022	protein C-terminus binding	molecular function	IDA[10988290]	4
GO:0005783	endoplasmic reticulum	cellular component	IDA[22792322]	20
GO:0017015	regulation of transforming growth factor beta receptor signaling pathway	biological process	IEA	1
GO:0006469	negative regulation of protein kinase activity	biological process	ISS	1
GO:0044325	ion channel binding	molecular function	IPI[17060380\|21084288]	5
GO:0046716	muscle cell cellular homeostasis	biological process	ISS	2
GO:0002027	regulation of heart rate	biological process	IMP[17060380]	2
GO:0030154	cell differentiation	biological process	ISS	10
GO:0031122	cytoplasmic microtubule organization	biological process	IEA	2
GO:0016049	cell growth	biological process	ISS	1
GO:0090279	regulation of calcium ion import	biological process	IDA[21084288]	1
GO:0042391	regulation of membrane potential	biological process	IDA[21084288]	4
GO:0050998	nitric-oxide synthase binding	molecular function	IEA	3
GO:0043014	alpha-tubulin binding	molecular function	IEA	2
GO:0016010	dystrophin-associated glycoprotein complex	cellular component	IDA[10988290]	1
GO:0071253	connexin binding	molecular function	IDA[19544087]	1
GO:1901380	negative regulation of potassium ion transmembrane transport	biological process	ISS[22879586]	1
GO:0051926	negative regulation of calcium ion transport	biological process	IDA[21084288]	2
GO:0010614	negative regulation of cardiac muscle hypertrophy	biological process	IMP[12847114]	2
GO:1901017	negative regulation of potassium ion transmembrane transporter activity	biological process	ISS[22879586]	1
GO:0060762	regulation of branching involved in mammary gland duct morphogenesis	biological process	IEA	1

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in PTSDgene
hsa04510	Focal adhesion	6

Gene related interactors from protein-protein interactions data in PINA v2 (count: 12)

Gene	Interactor	Interactor in PTSDgene?	Experiment Method	Interaction Type	PMID
CAV3	SUMO2	No	--	--	21362625 , 21362625
CAV3	SCN5A	No	--	--	17060380
CAV3	DAG1	No	biochemical	colocalization	10988290 , 10988290 , 10988290 , 10988290
CAV3	KCNMA1	No	--	--	15703204 , 15703204
CAV3	PRKCDBP	No	--	colocalization	10 , 19262564 , 10
CAV3	GNAS	No	--	--	7797570
CAV3	PTGES3	No	--	--	21988832 , 21988832
CAV3	NEDD4L	No	--	--	22879586 , 22879586
CAV3	SLC22A11	No	--	--	18985008
CAV3	PCBP1	No	--	--	21988832 , 21988832
CAV3	KCNH2	No	--	--	22879586 , 22879586
CAV3	JPH2	No	--	--	15541368 , 15541368