SNP Report
Basic Info
| Name | rs2267715 dbSNP Ensembl | ||
|---|---|---|---|
| Location | 7:30676471 - 30676471(+) | ||
| Variant Seq | A | ||
| Ancestral Allele | G | ||
| Ref Seq | G | ||
| Minor Allele Frequence | 0.404553 | ||
| Annotation | intron_variant; NMD_transcript_variant | ||
| Variant Effect | intron_variant(ENST00000471646, ENST00000452278, ENST00000348438, ENST00000341843, ENST00000506074); NMD_transcript_variant(ENST00000452278) | ||
| SIFT Annotation | tolerated_-_low_confidence; deleterious_-_low_confidence | ||
| SIFT Variant Effect | tolerated_-_low_confidence(ENST00000506074); deleterious_-_low_confidence(ENST00000471646) | ||
| PolyPhen Annotation | unknown; benign; possibly_damaging | ||
| PolyPhen Variant Effect | unknown(ENST00000445981); benign(ENST00000471646); possibly_damaging(ENST00000506074) | ||
| rSNP? | Yes Link in rVarBase | ||
| Related Regulatory Elements | Chromatin interactive region | ||
| Chromatin State | Weak transcription | ||
| No. of Marker's Association Results | 2 (Positive: 2; Negative: 0; Trend: 0) | ||
| Source | Literature | ||
SNP related association results
| Reference | Phenotype | Statistical Values | Author Comments | Marker's Category |
|---|---|---|---|---|
| Wolf, E. J.,2013 | Latent PTSD Severity | Structural equation modeling: In women: unstandardized B= ...... Structural equation modeling: In women: unstandardized B= -3.07, P-value= 0.003. In men: unstandardized B= -0.78, P-value= 0.35 More... | The SNP showed a significant association with PTSD severity ...... The SNP showed a significant association with PTSD severity only in women. More... | Significant |
| Wolf, E. J.,2013 | PTSD diagnosis | OR=0.68, 95% CI: 0.52-0.89, P-value uncorrected=0.004, P-val...... OR=0.68, 95% CI: 0.52-0.89, P-value uncorrected=0.004, P-value corrected=0.07. In women: OR= 0.48, 95% CI: 0.30-0.74, P-value= 0.001, corrected P-value= .02. In men: OR= 0.87, 95% CI: 0.62-1.24, P-value= 0.44. More... | It showed nominally significant associations with lifetime P...... It showed nominally significant associations with lifetime PTSD diagnosis, but didn't pass the multiple testing. These associations to be significant in women but not men. More... | Significant |
SNP related genes (count: 1)
| Approved Symbol | Approved Name | Location | No. of Association Results (Positive/Negative/Trend)  |
|---|---|---|---|
| CRHR2 | corticotropin releasing hormone receptor 2 | 7p14.3 | 2(2/0/0) |
SNPs in LD with rs2267715 (count: 11)
Literature-origin SNPs (count: 1)
LD-proxies (count: 10)
SNP related eQTL (count: 1)