PTSDgene database

SNP Report

Basic Info
Name rs2284218 dbSNP Ensembl
Location 7:30674717 - 30674717(+)
Variant Seq T
Ancestral Allele T
Ref Seq C
Minor Allele Frequence 0.395767
Annotation intron_variant; NMD_transcript_variant
Variant Effect intron_variant(ENST00000506074, ENST00000341843, ENST00000452278, ENST00000348438, ENST00000471646); NMD_transcript_variant(ENST00000452278)
SIFT Annotation deleterious
SIFT Variant Effect deleterious(ENST00000506074, ENST00000471646, ENST00000341843, ENST00000348438)
PolyPhen Annotation possibly_damaging; probably_damaging
PolyPhen Variant Effect possibly_damaging(ENST00000348438); probably_damaging(ENST00000506074, ENST00000471646, ENST00000341843)
rSNP? Yes Link in rVarBase
Related Regulatory Elements n/a
Chromatin State Weak transcription;Enhancers
No. of Marker's Association Results 2 (Positive: 2; Negative: 0; Trend: 0)
Source Literature

SNP related association results
Normal genetic study related association results (count: 2)
Reference Phenotype Statistical Values Author Comments Marker's Category
Wolf, E. J.,2013 Latent PTSD Severity Structural equation modeling: In women: unstandardized B= ...... Structural equation modeling: In women: unstandardized B= -2.89, P-value= 0.005. In men: unstandardized B= -0.95, P-value= 0.25 More... The SNP showed a significant association with PTSD severity ...... The SNP showed a significant association with PTSD severity only in women. More... Significant
Wolf, E. J.,2013 PTSD diagnosis OR=0.67, 95% CI: 0.52-0.88, P-value uncorrected=0.003, P-val...... OR=0.67, 95% CI: 0.52-0.88, P-value uncorrected=0.003, P-value corrected=0.05. In women: OR= 0.48, 95% CI: 0.31-0.75, P-value=0.001, corrected P-value= 0.02. More... It showed nominally significant associations with lifetime P...... It showed nominally significant associations with lifetime PTSD diagnosis, but didn't pass the multiple testing. It showed a female-specific association with PTSD that withstood permutation testing. More... Significant


SNP related genes (count: 1)
Approved Symbol Approved Name Location No. of Association Results (Positive/Negative/Trend)
CRHR2 corticotropin releasing hormone receptor 2 7p14.3 2(2/0/0)

SNPs in LD with rs2284218 (count: 11)
The LD data used here is based on 1000 Genome Phase I. LD SNP pairs were selected with a threshold r2<=0.8.

Literature-origin SNPs (count: 1)

LD-proxies (count: 10)


SNP related eQTL (count: 1)
Gene Symbol Gene Existed in PTSDgene? Tissue Trans/Cis Source
LRRC37A4P No Adipose Subcutaneous cis GTEx