PTSDgene database

SNP Report

Basic Info
Name rs2284216 dbSNP Ensembl
Location 7:30672345 - 30672345(+)
Variant Seq T
Ancestral Allele G
Ref Seq G
Minor Allele Frequence 0.167532
Annotation intron_variant; NMD_transcript_variant
Variant Effect intron_variant(ENST00000452278, ENST00000471646, ENST00000348438, ENST00000341843, ENST00000506074); NMD_transcript_variant(ENST00000452278)
SIFT Annotation deleterious
SIFT Variant Effect deleterious(ENST00000471646, ENST00000348438, ENST00000341843, ENST00000506074)
PolyPhen Annotation benign
PolyPhen Variant Effect benign(ENST00000471646, ENST00000348438, ENST00000341843, ENST00000506074)
rSNP? Yes Link in rVarBase
Related Regulatory Elements n/a
Chromatin State Weak transcription;Enhancers
No. of Marker's Association Results 1 (Positive: 1; Negative: 0; Trend: 0)
Source Literature

SNP related association results
Normal genetic study related association results (count: 1)
Reference Phenotype Statistical Values Author Comments Marker's Category
Wolf, E. J.,2013 PTSD diagnosis OR=0.54, 95% CI: 0.34-0.85, P-value uncorrected=0.007, P-val...... OR=0.54, 95% CI: 0.34-0.85, P-value uncorrected=0.007, P-value corrected=0.11 More... It showed nominally significant associations with lifetime P...... It showed nominally significant associations with lifetime PTSD diagnosis, but didn't pass the multiple testing. More... Significant

SNP related genes (count: 1)
Approved Symbol Approved Name Location No. of Association Results (Positive/Negative/Trend)
CRHR2 corticotropin releasing hormone receptor 2 7p14.3 2(2/0/0)

SNPs in LD with rs2284216 (count: 0)

SNP related eQTL (count: 1)
Gene Symbol Gene Existed in PTSDgene? Tissue Trans/Cis Source
LRRC37A4P No Adipose Subcutaneous cis GTEx