PTSDgene database

SNP Report

Basic Info
Name rs973002 dbSNP Ensembl
Location 7:30659288 - 30659288(+)
Variant Seq A
Ancestral Allele A
Ref Seq G
Minor Allele Frequence 0.216853
Annotation intron_variant; NMD_transcript_variant
Variant Effect intron_variant(ENST00000506074, ENST00000341843, ENST00000348438, ENST00000471646, ENST00000452278); NMD_transcript_variant(ENST00000452278)
SIFT Annotation tolerated
SIFT Variant Effect tolerated(ENST00000506074, ENST00000341843, ENST00000348438, ENST00000471646)
PolyPhen Annotation benign
PolyPhen Variant Effect benign(ENST00000506074, ENST00000341843, ENST00000348438, ENST00000471646)
rSNP? Yes Link in rVarBase
Related Regulatory Elements n/a
Chromatin State Weak transcription;Enhancers
No. of Marker's Association Results 1 (Positive: 1; Negative: 0; Trend: 0)
Source Literature

SNP related association results
Normal genetic study related association results (count: 1)
Reference Phenotype Statistical Values Author Comments Marker's Category
Wolf, E. J.,2013 PTSD diagnosis OR=0.65, 95% CI: 0.46-0.92, P-value uncorrected=0.01, P-valu...... OR=0.65, 95% CI: 0.46-0.92, P-value uncorrected=0.01, P-value corrected=0.21 More... It showed nominally significant associations with lifetime P...... It showed nominally significant associations with lifetime PTSD diagnosis, but didn't pass the multiple testing. More... Significant

SNP related genes (count: 1)
Approved Symbol Approved Name Location No. of Association Results (Positive/Negative/Trend)
CRHR2 corticotropin releasing hormone receptor 2 7p14.3 2(2/0/0)

SNPs in LD with rs973002 (count: 9)
The LD data used here is based on 1000 Genome Phase I. LD SNP pairs were selected with a threshold r2<=0.8.

Literature-origin SNPs (count: 0)

LD-proxies (count: 9)

SNP related eQTL (count: 1)
Gene Symbol Gene Existed in PTSDgene? Tissue Trans/Cis Source
LRRC37A4P No Adipose Subcutaneous cis GTEx