PTSDgene database

SNP Report

Basic Info
Name rs9370822 dbSNP Ensembl
Location 6:15544505 - 15544505(+)
Variant Seq C
Ancestral Allele A
Ref Seq A
Minor Allele Frequence 0.420927
Annotation intron_variant; NMD_transcript_variant
Variant Effect intron_variant(ENST00000515875, ENST00000506844, LRG_588t1, ENST00000510395, ENST00000462989, ENST00000511762, ENST00000355917, ENST00000509674, ENST00000344537, ENST00000622898, LRG_588t2, ENST00000338950, ENST00000513680); NMD_transcript_variant(ENST00000515875, ENST00000506844, ENST00000510395, ENST00000513680)
SIFT Annotation deleterious; tolerated
SIFT Variant Effect deleterious(LRG_588t2, ENST00000622898, ENST00000355917, ENST00000338950, LRG_588t1, ENST00000344537, ENST00000462989, ENST00000511762); tolerated(ENST00000515875, ENST00000509674)
PolyPhen Annotation benign; possibly_damaging
PolyPhen Variant Effect benign(LRG_588t2, ENST00000355917, ENST00000338950, ENST00000515875, ENST00000462989, ENST00000511762); possibly_damaging(ENST00000622898, LRG_588t1, ENST00000344537, ENST00000509674)
rSNP? Yes Link in rVarBase
Related Regulatory Elements n/a
Chromatin State Weak transcription;ZNF genes & repeats;Enhancers
No. of Marker's Association Results 2 (Positive: 2; Negative: 0; Trend: 0)
Source Literature

SNP related association results
Normal genetic study related association results (count: 2)
Reference Phenotype Statistical Values Author Comments Marker's Category
Voisey, J.,2010 PTSD Allele frequencies: Pearson's chi-square test: X2 Allele frequencies: Pearson's chi-square test: X2= 12.603, P-value= 0.0004, Odd's ratio (95% CI): 1.78(1.28-2.50), Genotype frequencies: Pearson's chi-square test: P-value= 0.002, Mantel-Haenszel chi-square test for trend: P-value= 0.0004 More... The SNP was found to be associated with PTSD both at the all...... The SNP was found to be associated with PTSD both at the allel level and genotype level. Individuals with PTSD were more than three times as likely to carry the CC genotype compared to the AA genotype. More... Significant
Voisey, J.,2010 PTSD At the allele level(case=127), OR=1.78, P-value=0.0004; at t...... At the allele level(case=127), OR=1.78, P-value=0.0004; at the genotype level(case=127), P-value(determined by Pearson's X2 test)=0.002, P-value(determined using the extended Mantel-Haenszel test for trend)=0.0004. More... rs9370822 was found to be associated with PTSD at the allele...... rs9370822 was found to be associated with PTSD at the allele level. At the genotype level, rs9370822 was still associated with PTSD. More... Significant

SNP related genes (count: 1)
Approved Symbol Approved Name Location No. of Association Results (Positive/Negative/Trend)
DTNBP1 dystrobrevin binding protein 1 6p22.3 5(2/3/0)

SNPs in LD with rs9370822 (count: 8)
The LD data used here is based on 1000 Genome Phase I. LD SNP pairs were selected with a threshold r2<=0.8.

Literature-origin SNPs (count: 0)

LD-proxies (count: 8)

SNP related eQTL (count: 1)
Gene Symbol Gene Existed in PTSDgene? Tissue Trans/Cis Source
CRHR1 Yes Adipose Subcutaneous cis GTEx