PTSDgene database

Pathway Enrichment Analysis Protein-Protein Interaction Analysis

Study Report

Study Information

Basic Info

Reference	Voisey, J.,2010 PMID: 20615259
Citation	Voisey, J., et al. (2010). "A polymorphism in the dysbindin gene (DTNBP1) associated with multiple psychiatric disorders including schizophrenia." Behav Brain Funct 6: 41.
Phenotype	PTSD
Trauma	Vietnam combat
Study Design	Case-control
Study Type	Candidate gene association study
Sample Size	127 patients, 250 controls
SNP/Marker Size	1 SNP
Predominant Ethnicity	Caucasian
Population	Caucasian
Gender	Case: all male. Control group: 102 female and 148 male.
Age	Case: mean age=52.3 years, SD=6.1 years. Control group: mean age=36.8 years, SD=12.8 years.

Detail Info

Sample Diagnosis	DSM-IV
Related Diagnostic Tools	Mississippi Scale for combat-related PTSD
Sample Status	All subjects were Vietnam combat veterans who had served in the Australian Armed Forces.
Controls Exposed	No
Replication Size	None
Result Summary	The DTNBP1 polymorphism was significantly associated with post-traumatic stress disorder (PTSD) as well as nicotine and opiate dependence but not alcohol dependence. Individuals suffering PTSD were more than three times as likely to carry the CC genotype compared to the AA genotype. Individuals with nicotine or opiate dependence were more than twice as likely to carry the CC genotype compared to the AA genotype. This study provides further support for the importance of DTNBP1 in psychiatric conditions and suggests that there is a common underlying molecular defect involving DTNBP1 that contributes to the development of several anxiety and addictive disorders that are generally recognised as separate clinical conditions. These disorders may actually be different expressions of a single metabolic pathway perturbation. As our participant numbers are limited our observations should be viewed with caution until they are independently replicated.
Potential Biomarker	None

Genetic result reported by this study

Normal genetic result reported by this study (count: 1)

Marker	Phenotype	Related Gene	Statistical Values	Author Comments	Marker's Category
rs9370822	PTSD	DTNBP1	At the allele level(case=127), OR=1.78, P-value=0.0004; at the genotype level(case=127), P-value(determined by Pearson's X² test)=0.002, P-value(determined using the extended Mantel-Haenszel test for trend)=0.0004.	rs9370822 was found to be associated with PTSD at the allele...... rs9370822 was found to be associated with PTSD at the allele level. At the genotype level, rs9370822 was still associated with PTSD. More...	Significant