Study Report
Study Information
Basic Info
| Reference |
Voisey, J.,2010 PMID: 2911395
|
| Citation |
Voisey, J., et al. (2010). "A polymorphism in the dysbindin gene (DTNBP1) associated with multiple psychiatric disorders including schizophrenia." Behav Brain Funct 6: 41. |
| Phenotype |
PTSD |
| Trauma |
Vietnam combat |
| Study Design |
Case-control |
| Study Type |
Candidate gene association study |
| Sample Size |
127 cases, 250 controls |
| SNP/Marker Size |
1 SNP |
| Predominant Ethnicity |
Caucasian |
| Population |
Australian |
| Gender |
Case: not mentioned, Control: 148 males and 102 females |
| Age |
Case: mean age= 52.3 years, SD=6.1, Control: mean age=36.8 years, SD=12.8 years |
Detail Info
| Sample Diagnosis |
DSM-IV |
| Related Diagnostic Tools |
Mississippi Scale for combat-related PTSD, patients were assessed for PTSD by a consultant psychiatrist or a senior psychiatric registrar using DSM-IV criteria. |
| Sample Status |
Patients were excluded from the study if they had a diagnosis of psychosis, bipolar disorder, obsessive-compulsive disorder, or organic brain syndrome including dementia. |
| Controls Exposed |
NS |
| Replication Size |
None |
| Result Summary |
The DTNBP1 polymorphism was significantly associated with post-traumatic stress disorder (PTSD) as well as nicotine and opiate dependence but not alcohol dependence. Individuals suffering PTSD were more than three times as likely to carry the CC genotype compared to the AA genotype. Individuals with nicotine or opiate dependence were more than twice as likely to carry the CC genotype compared to the AA genotype. |
| Potential Biomarker |
None |
Genetic result reported by this study
Normal genetic result reported by this study (count: 1)
| Marker |
Phenotype |
Related Gene |
Statistical Values |
Author Comments |
Marker's Category |
|
rs9370822
|
PTSD |
DTNBP1 |
Allele frequencies: Pearson's chi-square test: X2= 12.603, P-value= 0.0004, Odd's ratio (95% CI): 1.78(1.28-2.50), Genotype frequencies: Pearson's chi-square test: P-value= 0.002, Mantel-Haenszel chi-square test for trend: P-value= 0.0004 |
The SNP was found to be associated with PTSD both at the all......
The SNP was found to be associated with PTSD both at the allel level and genotype level. Individuals with PTSD were more than three times as likely to carry the CC genotype compared to the AA genotype.
More...
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Significant |
