SNP Report
Basic Info
| Name | rs1130864 dbSNP Ensembl | ||
|---|---|---|---|
| Location | 1:159713301 - 159713301(+) | ||
| Variant Seq | A | ||
| Ancestral Allele | G | ||
| Ref Seq | G | ||
| Minor Allele Frequence | 0.204673 | ||
| Annotation | 3_prime_UTR_variant; intron_variant; non_coding_transcript_variant | ||
| Variant Effect | 3_prime_UTR_variant(ENST00000255030); intron_variant(ENST00000473196, ENST00000489317, ENST00000437342, ENST00000368112, ENST00000368110, ENST00000368111); non_coding_transcript_variant(ENST00000473196, ENST00000489317) | ||
| SIFT Annotation | deleterious; tolerated | ||
| SIFT Variant Effect | deleterious(ENST00000437342); tolerated(ENST00000255030) | ||
| PolyPhen Annotation | possibly_damaging | ||
| PolyPhen Variant Effect | possibly_damaging(ENST00000255030, ENST00000437342) | ||
| rSNP? | Yes Link in rVarBase | ||
| Related Regulatory Elements | n/a | ||
| Chromatin State | Active TSS;Enhancers | ||
| No. of Marker's Association Results | 2 (Positive: 2; Negative: 0; Trend: 0) | ||
| Source | Literature | ||
SNP related association results
| Reference | Phenotype | Statistical Values | Author Comments | Marker's Category |
|---|---|---|---|---|
| Michopoulos, V.,2015 | PTSD diagnosis | T=2.89, P-value=0.0040; after covarying for principal compon...... T=2.89, P-value=0.0040; after covarying for principal components: t=2.80, P-value=0.005; after covarying for principal components,sex,age,education, current employment, income, and total trauma experienced/witnessed: t=2.81, P-value=0.005 More... | Using a dominant model,rs1130864 was associated with a categ...... Using a dominant model,rs1130864 was associated with a categorical diagnosis of PTSD, and the association remained after covarying for principal components, the effect of rs1130864 genotype on PTSD diagnosis survived after covarying for principal components, sex, age, education, current employment, income, and total trauma experienced/witnessed. More... | Significant |
| Michopoulos, V.,2015 | PTSD symptoms | T=-0.11, P-value=0.004; controlled for population stratifica...... T=-0.11, P-value=0.004; controlled for population stratification: t=2.65, P-value=0.008; after covarying for principal components,sex,age,education, current employment, income, and total trauma experienced/witnessed: t=2.70, P-value=0.007 More... | Using a dominant model, rs1130864 was significantly associat...... Using a dominant model, rs1130864 was significantly associated with overall PTSD symptoms. The main effects of genotype on PTSD symptoms were maintained when the analyses controlled for population stratification (using principal components) in the dominant model. The effect of rs1130864 genotype on PTSD symptoms survived after covarying for principal components, sex, age, education, current employment, income, and total trauma experienced/witnessed. More... | Significant |
SNP related genes (count: 1)
| Approved Symbol | Approved Name | Location | No. of Association Results (Positive/Negative/Trend)  |
|---|---|---|---|
| CRP | C-reactive protein, pentraxin-related | 1q23.2 | 3(2/1/0) |
SNPs in LD with rs1130864 (count: 0)
SNP related eQTL (count: 1)