PTSDgene database

SNP Report

Basic Info
Name rs1130864 dbSNP Ensembl
Location 1:159713301 - 159713301(+)
Variant Seq A
Ancestral Allele G
Ref Seq G
Minor Allele Frequence 0.204673
Annotation 3_prime_UTR_variant; intron_variant; non_coding_transcript_variant
Variant Effect 3_prime_UTR_variant(ENST00000255030); intron_variant(ENST00000473196, ENST00000489317, ENST00000437342, ENST00000368112, ENST00000368110, ENST00000368111); non_coding_transcript_variant(ENST00000473196, ENST00000489317)
SIFT Annotation deleterious; tolerated
SIFT Variant Effect deleterious(ENST00000437342); tolerated(ENST00000255030)
PolyPhen Annotation possibly_damaging
PolyPhen Variant Effect possibly_damaging(ENST00000255030, ENST00000437342)
rSNP? Yes Link in rVarBase
Related Regulatory Elements n/a
Chromatin State Active TSS;Enhancers
No. of Marker's Association Results 2 (Positive: 2; Negative: 0; Trend: 0)
Source Literature

SNP related association results
Normal genetic study related association results (count: 2)
Reference Phenotype Statistical Values Author Comments Marker's Category
Michopoulos, V.,2015 PTSD diagnosis T=2.89, P-value=0.0040; after covarying for principal compon...... T=2.89, P-value=0.0040; after covarying for principal components: t=2.80, P-value=0.005; after covarying for principal components,sex,age,education, current employment, income, and total trauma experienced/witnessed: t=2.81, P-value=0.005 More... Using a dominant model,rs1130864 was associated with a categ...... Using a dominant model,rs1130864 was associated with a categorical diagnosis of PTSD, and the association remained after covarying for principal components, the effect of rs1130864 genotype on PTSD diagnosis survived after covarying for principal components, sex, age, education, current employment, income, and total trauma experienced/witnessed. More... Significant
Michopoulos, V.,2015 PTSD symptoms T=-0.11, P-value=0.004; controlled for population stratifica...... T=-0.11, P-value=0.004; controlled for population stratification: t=2.65, P-value=0.008; after covarying for principal components,sex,age,education, current employment, income, and total trauma experienced/witnessed: t=2.70, P-value=0.007 More... Using a dominant model, rs1130864 was significantly associat...... Using a dominant model, rs1130864 was significantly associated with overall PTSD symptoms. The main effects of genotype on PTSD symptoms were maintained when the analyses controlled for population stratification (using principal components) in the dominant model. The effect of rs1130864 genotype on PTSD symptoms survived after covarying for principal components, sex, age, education, current employment, income, and total trauma experienced/witnessed. More... Significant


SNP related genes (count: 1)
Approved Symbol Approved Name Location No. of Association Results (Positive/Negative/Trend)
CRP C-reactive protein, pentraxin-related 1q23.2 3(2/1/0)

SNPs in LD with rs1130864 (count: 0)

SNP related eQTL (count: 1)
Gene Symbol Gene Existed in PTSDgene? Tissue Trans/Cis Source
CRHR1 Yes Adipose Subcutaneous cis GTEx