PTSDgene database

Pathway Enrichment Analysis Protein-Protein Interaction Analysis

Study Report

Study Information

Basic Info

Reference	Michopoulos, V.,2015 PMID: 25827033
Citation	Michopoulos, V., et al. (2015). "Association of CRP genetic variation and CRP level with elevated PTSD symptoms and physiological responses in a civilian population with high levels of trauma." Am J Psychiatry 172(4): 353-362.
Phenotype	PTSD symptoms, PTSD diagnosis
Trauma	Various
Study Design	Cross-sectional study
Study Type	Candidate gene association study
Sample Size	2692 samples
SNP/Marker Size	6 SNPs
Predominant Ethnicity	Black
Population	African American (92.9%), White(3.7%)
Gender	800 males, 1892 females
Age	Mean age=39.3 years, SD=12.5

Detail Info

Genetic result reported by this study

Normal genetic result reported by this study (count: 7)

Marker	Phenotype	Related Gene	Statistical Values	Author Comments	Marker's Category
rs1130864	PTSD diagnosis	CRP	T=2.89, P-value=0.0040; after covarying for principal components: t=2.80, P-value=0.005; after covarying for principal components,sex,age,education, current employment, income, and total trauma experienced/witnessed: t=2.81, P-value=0.005	Using a dominant model,rs1130864 was associated with a categ...... Using a dominant model,rs1130864 was associated with a categorical diagnosis of PTSD, and the association remained after covarying for principal components, the effect of rs1130864 genotype on PTSD diagnosis survived after covarying for principal components, sex, age, education, current employment, income, and total trauma experienced/witnessed. More...	Significant
rs1130864	PTSD symptoms	CRP	T=-0.11, P-value=0.004; controlled for population stratification: t=2.65, P-value=0.008; after covarying for principal components,sex,age,education, current employment, income, and total trauma experienced/witnessed: t=2.70, P-value=0.007	Using a dominant model, rs1130864 was significantly associat...... Using a dominant model, rs1130864 was significantly associated with overall PTSD symptoms. The main effects of genotype on PTSD symptoms were maintained when the analyses controlled for population stratification (using principal components) in the dominant model. The effect of rs1130864 genotype on PTSD symptoms survived after covarying for principal components, sex, age, education, current employment, income, and total trauma experienced/witnessed. More...	Significant
rs1205	PTSD symptoms	CRP	T=-0.11, P-value=0.91	No significant effect on PTSD symptoms. No significant effect on PTSD symptoms.	Non-significant
rs3093066	PTSD symptoms	CRP	T=0.66, P-value=0.51	No significant effect on PTSD symptoms. No significant effect on PTSD symptoms.	Non-significant
rs3091244	PTSD symptoms	CRP	T=0.39, P-value=0.70	No significant effect on PTSD symptoms. No significant effect on PTSD symptoms.	Non-significant
rs3093068	PTSD symptoms	CRP	T=-2.31, P-value=0.02	No significant effect on PTSD symptoms. No significant effect on PTSD symptoms.	Non-significant
rs3093067	PTSD symptoms	CRP	T=1.31, P-value=0.19	No significant effect on PTSD symptoms. No significant effect on PTSD symptoms.	Non-significant