SNP Report

Basic Info

Name	rs72818458 dbSNP Ensembl
Location	10:60040130 - 60040130(+)
Variant Seq	A
Ancestral Allele	T
Ref Seq	T
Minor Allele Frequence	0.0283546
Annotation	downstream_gene_variant; intron_variant; non_coding_transcript_variant
Variant Effect	downstream_gene_variant(ENST00000616444, ENST00000610321, ENST00000617800); intron_variant(ENST00000503366, ENST00000280772, ENST00000355288, ENST00000373827, ENST00000489505, ENST00000373820, ENST00000480699, ENST00000502769, ENST00000612776, ENST00000618374); non_coding_transcript_variant(ENST00000489505, ENST00000480699)
SIFT Annotation	deleterious_-_low_confidence
SIFT Variant Effect	deleterious_-_low_confidence(ENST00000612776, ENST00000617800, ENST00000373820, ENST00000502769, ENST00000355288, ENST00000373827, ENST00000280772, ENST00000610321, ENST00000616444, ENST00000503366)
PolyPhen Annotation	unknown; benign; probably_damaging
PolyPhen Variant Effect	unknown(ENST00000616444); benign(ENST00000355288, ENST00000503366); probably_damaging(ENST00000612776, ENST00000617800, ENST00000373820, ENST00000502769, ENST00000373827, ENST00000280772, ENST00000610321)
rSNP?	Yes Link in rVarBase
Related Regulatory Elements	n/a
Chromatin State	Weak transcription;Enhancers;Strong transcription
No. of Marker's Association Results	1 (Positive: 1; Negative: 0; Trend: 0)
Source	Literature

SNP related association results

Normal genetic study related association results (count: 1)

Reference	Phenotype	Statistical Values	Author Comments	Marker's Category
Logue, M. W.,2013	PTSD	OR=0.47, P-value=0.0020, corrected P-value=0.11 OR=0.47, P-value=0.0020, corrected P-value=0.11	The SNP was associated with PTSD at the P-value<0.01 level. The SNP was associated with PTSD at the P-value<0.01 level.	Significant

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Association Results (Positive/Negative/Trend)
ANK3	ankyrin 3, node of Ranvier (ankyrin G)	10q21	2(2/0/0)

SNPs in LD with rs72818458 (count: 1)

The LD data used here is based on 1000 Genome Phase I. LD SNP pairs were selected with a threshold r²<=0.8.

rs_ID	Literature-origin SNPs with LD	Annotation	r²[population]
rs72818455	rs72818458	downstream_gene_variant; intron_variant; non_coding_transcript_variant	1.0000[EUR]

SNP related eQTL (count: 1)

Gene Symbol	Gene Existed in PTSDgene?	Tissue	Trans/Cis	Source
RP11-259G18.3	No	Adipose Subcutaneous	cis	GTEx