PTSDgene database

Study Report

Study Information
Basic Info
Reference
Citation Logue, M. W., et al. (2013). "The ankyrin-3 gene is associated with posttraumatic stress disorder and externalizing comorbidity." Psychoneuroendocrinology 38(10): 2249-2257.
Phenotype PTSD
Trauma Various
Study Design Cross-sectional study
Study Type Candidate gene association study
Sample Size 554 samples
SNP/Marker Size 359 SNPs
Predominant Ethnicity Caucasian
Population White non-Hispanic ancestry
Gender 339 males, 215 females
Age Subsample of participants included in analysis of lifetime PTSD diagnosis: mean age=51.93 years; subsample of participants included in analyses of the externalizing: mean age=51.68 years.

Detail Info

Genetic result reported by this study
Normal genetic result reported by this study (count: 14)
Marker Phenotype Related Gene Statistical Values Author Comments Marker's Category
rs7917800 PTSD ANK3 OR=0.54, P-value=0.0046, corrected P-value=0.22 The SNP was associated with PTSD at the P-value<0.01 level. The SNP was associated with PTSD at the P-value<0.01 level. Significant
rs72818458 - rs28932171 - rs11599164 - rs17208576 - rs9804190 - rs7917800 - rs7098848, AGAAAAG PTSD ANK3 OR=0.426, P-value=0.00042 The haplotype was more strongly associated with protection f...... The haplotype was more strongly associated with protection from PTSD than any individual SNP. More... Significant
rs1049862 PTSD ANK3 OR=0.85, P-value=0.23, corrected P-value=1 The SNP was not associated with PTSD at the P-value<0.01 lev...... The SNP was not associated with PTSD at the P-value<0.01 level. More... Non-significant
rs28932171 PTSD ANK3 OR=0.48, P-value=0.00060, corrected P-value=0.045 The SNP was associated with PTSD at the P-value<0.01 level. The SNP was associated with PTSD at the P-value<0.01 level. Significant
rs12357206 PTSD ANK3 OR=0.85, P-value=0.24, corrected P-value=1 The SNP was not associated with PTSD at the P-value<0.01 lev...... The SNP was not associated with PTSD at the P-value<0.01 level. More... Non-significant
rs11813307 PTSD ANK3 OR=0.82, P-value=0.15, corrected P-value=1 The SNP was not associated with PTSD at the P-value<0.01 lev...... The SNP was not associated with PTSD at the P-value<0.01 level. More... Non-significant
rs9804190 PTSD ANK3 OR=0.71, P-value=0.042, corrected P-value=0.93 The bipolar disorder-associated SNP rs9804190 was the only S...... The bipolar disorder-associated SNP rs9804190 was the only SNPin ANK3 that was nominally significantly associated (P-value< 0.05) with both PTSD and externalizing. More... Significant
rs1049862 - rs12357206 - rs10821659 - rs11813307, GGAA PTSD ANK3 P-value=0.60 This haplotype was not associated with PTSD. This haplotype was not associated with PTSD. Non-significant
rs11599447 PTSD ANK3 OR=0.44, P-value=0.0054, corrected P-value=0.34 The SNP was associated with PTSD at the P-value<0.01 level. The SNP was associated with PTSD at the P-value<0.01 level. Significant
rs11599164 PTSD ANK3 OR=0.48, P-value=0.00060, corrected P-value=0.045 The SNP was associated with PTSD at the P-value<0.01 level. The SNP was associated with PTSD at the P-value<0.01 level. Significant
rs72818458 PTSD ANK3 OR=0.47, P-value=0.0020, corrected P-value=0.11 The SNP was associated with PTSD at the P-value<0.01 level. The SNP was associated with PTSD at the P-value<0.01 level. Significant
rs17208576 PTSD ANK3 OR=0.48, P-value=0.00060, corrected P-value=0.045 The SNP was associated with PTSD at the P-value<0.01 level. The SNP was associated with PTSD at the P-value<0.01 level. Significant
rs7098848 PTSD ANK3 OR=0.53, P-value=0.0028, corrected P-value=0.20 The SNP was associated with PTSD at the P-value<0.01 level. The SNP was associated with PTSD at the P-value<0.01 level. Significant
rs10821659 PTSD ANK3 OR=0.93, P-value=0.64, corrected P-value=1 The SNP was not associated with PTSD at the P-value<0.01 lev...... The SNP was not associated with PTSD at the P-value<0.01 level. More... Non-significant