PTSDgene database

Pathway Enrichment Analysis Protein-Protein Interaction Analysis

Study Report

Study Information

Basic Info

Reference	Logue, M. W.,2013 PMID: 23796624
Citation	Logue, M. W., et al. (2013). "The ankyrin-3 gene is associated with posttraumatic stress disorder and externalizing comorbidity." Psychoneuroendocrinology 38(10): 2249-2257.
Phenotype	PTSD
Trauma	Various
Study Design	Cross-sectional study
Study Type	Candidate gene association study
Sample Size	554 samples
SNP/Marker Size	359 SNPs
Predominant Ethnicity	Caucasian
Population	White non-Hispanic ancestry
Gender	339 males, 215 females
Age	Subsample of participants included in analysis of lifetime PTSD diagnosis: mean age=51.93 years; subsample of participants included in analyses of the externalizing: mean age=51.68 years.

Detail Info

Sample Diagnosis	DSM-IV
Related Diagnostic Tools	The Clinician-Administered PTSD Scale (CAPS), the lifetime alcohol abuse and dependence, cannabis abuse and dependence, cocaine abuse and dependence, and adult anti-social personality disorder modules of the Structured Clinical Interview for DSM-IV disorders and the SCID-II, the International Personality Disorders Exam (IPDE).
Sample Status	In this sample, 15 PTSD cases met criteria for a bipolar 1 diagnosis and two met for a bipolar 2 diagnosis. The presence of schizophrenia was not assessed.
Controls Exposed	NA
Replication Size	None
Result Summary	rs9804190 was associated with both externalizing and PTSD. Analysis of other ANK3 SNPs identified several that were more strongly associated with either trait. The most significant association with externalizing was observed at rs1049862. The most significant association with PTSD was found with three SNPs in complete linkage disequilibrium-rs28932171, rs11599164, and rs17208576.
Potential Biomarker	None

Genetic result reported by this study

Normal genetic result reported by this study (count: 14)

Marker	Phenotype	Related Gene	Statistical Values	Author Comments	Marker's Category
rs7917800	PTSD	ANK3	OR=0.54, P-value=0.0046, corrected P-value=0.22	The SNP was associated with PTSD at the P-value<0.01 level. The SNP was associated with PTSD at the P-value<0.01 level.	Significant
rs72818458 - rs28932171 - rs11599164 - rs17208576 - rs9804190 - rs7917800 - rs7098848, AGAAAAG	PTSD	ANK3	OR=0.426, P-value=0.00042	The haplotype was more strongly associated with protection f...... The haplotype was more strongly associated with protection from PTSD than any individual SNP. More...	Significant
rs1049862	PTSD	ANK3	OR=0.85, P-value=0.23, corrected P-value=1	The SNP was not associated with PTSD at the P-value<0.01 lev...... The SNP was not associated with PTSD at the P-value<0.01 level. More...	Non-significant
rs28932171	PTSD	ANK3	OR=0.48, P-value=0.00060, corrected P-value=0.045	The SNP was associated with PTSD at the P-value<0.01 level. The SNP was associated with PTSD at the P-value<0.01 level.	Significant
rs12357206	PTSD	ANK3	OR=0.85, P-value=0.24, corrected P-value=1	The SNP was not associated with PTSD at the P-value<0.01 lev...... The SNP was not associated with PTSD at the P-value<0.01 level. More...	Non-significant
rs11813307	PTSD	ANK3	OR=0.82, P-value=0.15, corrected P-value=1	The SNP was not associated with PTSD at the P-value<0.01 lev...... The SNP was not associated with PTSD at the P-value<0.01 level. More...	Non-significant
rs9804190	PTSD	ANK3	OR=0.71, P-value=0.042, corrected P-value=0.93	The bipolar disorder-associated SNP rs9804190 was the only S...... The bipolar disorder-associated SNP rs9804190 was the only SNPin ANK3 that was nominally significantly associated (P-value< 0.05) with both PTSD and externalizing. More...	Significant
rs1049862 - rs12357206 - rs10821659 - rs11813307, GGAA	PTSD	ANK3	P-value=0.60	This haplotype was not associated with PTSD. This haplotype was not associated with PTSD.	Non-significant
rs11599447	PTSD	ANK3	OR=0.44, P-value=0.0054, corrected P-value=0.34	The SNP was associated with PTSD at the P-value<0.01 level. The SNP was associated with PTSD at the P-value<0.01 level.	Significant
rs11599164	PTSD	ANK3	OR=0.48, P-value=0.00060, corrected P-value=0.045	The SNP was associated with PTSD at the P-value<0.01 level. The SNP was associated with PTSD at the P-value<0.01 level.	Significant
rs72818458	PTSD	ANK3	OR=0.47, P-value=0.0020, corrected P-value=0.11	The SNP was associated with PTSD at the P-value<0.01 level. The SNP was associated with PTSD at the P-value<0.01 level.	Significant
rs17208576	PTSD	ANK3	OR=0.48, P-value=0.00060, corrected P-value=0.045	The SNP was associated with PTSD at the P-value<0.01 level. The SNP was associated with PTSD at the P-value<0.01 level.	Significant
rs7098848	PTSD	ANK3	OR=0.53, P-value=0.0028, corrected P-value=0.20	The SNP was associated with PTSD at the P-value<0.01 level. The SNP was associated with PTSD at the P-value<0.01 level.	Significant
rs10821659	PTSD	ANK3	OR=0.93, P-value=0.64, corrected P-value=1	The SNP was not associated with PTSD at the P-value<0.01 lev...... The SNP was not associated with PTSD at the P-value<0.01 level. More...	Non-significant