PTSDgene database

Pathway Enrichment Analysis Protein-Protein Interaction Analysis

Variant Report

Basic Info

Name	DAT_3'UTR_VNTR
Type	VNTR
Location	3'-untranslated region
Related Gene	SLC6A3
No. of Association Result	12 (Positive: 6; Negative: 6; Trend: 0)

Variant related studies

Normal genetic study related association result (count: 12)

Reference	Phenotype	Statistical Values	Author Comments	Marker's Category
Valente, N. L.,2011	PTSD	Between PTSD+, PTSD?, and community control groups: P-value...... Between PTSD+, PTSD?, and community control groups: P-value=0.028, between PTSD+ and community control group: genotype: P-value=0.008, allele: P-value=0.004, between PTSD+ and PTSD?: P-value=0.3. More...	For the DAT1 3'UTR VNTR, a difference was found between PTSD...... For the DAT1 3'UTR VNTR, a difference was found between PTSD+, PTSD?, and community control group. Between PTSD+ and community control group, a difference was found regarding allelic frequencies and genetic frequencies. When comparing PTSD+ and PTSD? groups, no statistical difference was observed. More...	Significant
Drury, S. S.,2009	PTSD category B symptom score	Z=1.02, P-value>0.05 Z=1.02, P-value>0.05	There was no significant differences with Criterion B sympto...... There was no significant differences with Criterion B symptom counts. More...	Non-significant
Bailey, J. N.,2010	PTSD category B symptom score	B=-1.23, P-value=0.35 B=-1.23, P-value=0.35	There was no association between DAT/9 repeat allele and PTS...... There was no association between DAT/9 repeat allele and PTSD diagnosis. More...	Non-significant
Drury, S. S.,2009	PTSD category C symptom score	Z=1.90, P-value>0.05 Z=1.90, P-value>0.05	There was no significant differences with Criterion c sympto...... There was no significant differences with Criterion c symptom counts. More...	Non-significant
Bailey, J. N.,2010	PTSD category C symptom score	B=-0.50, P-value=0.72 B=-0.50, P-value=0.72	There was no association between DAT/9 repeat allele and PTS...... There was no association between DAT/9 repeat allele and PTSD diagnosis. More...	Non-significant
Drury, S. S.,2009	PTSD category D symptom score	Z=2.46, P-value<0.05 Z=2.46, P-value<0.05	Children with the 9 allele had significantly more Criterion ...... Children with the 9 allele had significantly more Criterion D symptoms compared to homozygous 10/10 children. More...	Significant
Segman, R. H.,2002	PTSD diagnosis	Allele frequency: X²=6.31, P-value=0.012. Genoty...... Allele frequency: X²=6.31, P-value=0.012. Genotype distribution: X²=6.1, P-value=0.047. More...	Significant excess of 9 repeat allele was observed among PTS...... Significant excess of 9 repeat allele was observed among PTSD patients. An excess of 9 repeat homozygous genotype was also observed in PTSD. More...	Significant
Drury, S. S.,2009	PTSD diagnosis	OR=2.40, 95% CI=1.02-5.67, Wald X²=4.00, P-value<...... OR=2.40, 95% CI=1.02-5.67, Wald X²=4.00, P-value< 0.05 More...	Logistic regression results revealed that there is a signifi...... Logistic regression results revealed that there is a significant difference in PTSD diagnosis according to genotype classification. More...	Significant
Bailey, J. N.,2010	PTSD diagnosis	X²=2.6, P-value=0.11, after controlling for alcoh...... X²=2.6, P-value=0.11, after controlling for alcohol dependency: B=?2.44, P-value=0.65 More...	There was no association between DAT/9 repeat allele and PTS...... There was no association between DAT/9 repeat allele and PTSD diagnosis. More...	Non-significant
Chang, S. C.,2012	PTSD diagnosis	OR=1.98, 95% CI=1.02-3.86, P-value=0.04 OR=1.98, 95% CI=1.02-3.86, P-value=0.04	After adjusting for age, sex, socio-economic status, race, s...... After adjusting for age, sex, socio-economic status, race, smoking, number of traumatic events and lifetime depression, 9R allele carriers showed almost twice the risk of PTSD compared to 10R/10R carriers. More...	Significant
Drury, S. S.,2009	PTSD symptoms	Z=2.22, P-value<0.05 Z=2.22, P-value<0.05	Individuals with the 9 allele (9/9 or 9/10 genotypes) had si...... Individuals with the 9 allele (9/9 or 9/10 genotypes) had significantly greater total number of PTSD symptoms than homozygous 10 children. More...	Significant
Bailey, J. N.,2010	PTSD symptoms	B=-1.14, P-value=0.87 B=-1.14, P-value=0.87	There was no association between DAT/9 repeat allele and PTS...... There was no association between DAT/9 repeat allele and PTSD diagnosis. More...	Non-significant