PTSDgene database

SNP Report

Basic Info
Name rs3766246 dbSNP Ensembl
Location 1:46399999 - 46399999(+)
Variant Seq G
Ancestral Allele G
Ref Seq A
Minor Allele Frequence 0.434505
Annotation intron_variant; non_coding_transcript_variant
Variant Effect intron_variant(ENST00000243167, ENST00000493735, ENST00000468718); non_coding_transcript_variant(ENST00000493735, ENST00000468718)
SIFT Annotation deleterious
SIFT Variant Effect deleterious(ENST00000243167)
PolyPhen Annotation benign
PolyPhen Variant Effect benign(ENST00000243167)
rSNP? Yes Link in rVarBase
Related Regulatory Elements Chromatin interactive region
Chromatin State Weak transcription;Enhancers;Flanking Active TSS
No. of Marker's Association Results 1 (Positive: 0; Negative: 1; Trend: 0)
Source Literature

SNP related association results
Normal genetic study related association results (count: 1)
Reference Phenotype Statistical Values Author Comments Marker's Category
Pardini, M.,2012 PTSD C/- compared with T/T: In TPBI subjects without vmPFC lesi...... C/- compared with T/T: In TPBI subjects without vmPFC lesions: P-value= 0.6. In the vmPFC lesion group: P-value= 0.09. More... No significant difference in PTSD prevalence between genotyp...... No significant difference in PTSD prevalence between genotypes in both subjects. More... Non-significant

SNP related genes (count: 1)
Approved Symbol Approved Name Location No. of Association Results (Positive/Negative/Trend)
FAAH fatty acid amide hydrolase 1p35-p34 8(3/5/0)

SNPs in LD with rs3766246 (count: 8)
The LD data used here is based on 1000 Genome Phase I. LD SNP pairs were selected with a threshold r2<=0.8.

Literature-origin SNPs (count: 1)

LD-proxies (count: 7)

SNP related eQTL (count: 1)
Gene Symbol Gene Existed in PTSDgene? Tissue Trans/Cis Source
CRHR1 Yes Adipose Subcutaneous cis GTEx