SNP Report

Basic Info

Name	rs3766246 dbSNP Ensembl
Location	1:46399999 - 46399999(+)
Variant Seq	G
Ancestral Allele	G
Ref Seq	A
Minor Allele Frequence	0.434505
Annotation	intron_variant; non_coding_transcript_variant
Variant Effect	intron_variant(ENST00000243167, ENST00000493735, ENST00000468718); non_coding_transcript_variant(ENST00000493735, ENST00000468718)
SIFT Annotation	deleterious
SIFT Variant Effect	deleterious(ENST00000243167)
PolyPhen Annotation	benign
PolyPhen Variant Effect	benign(ENST00000243167)
rSNP?	Yes Link in rVarBase
Related Regulatory Elements	Chromatin interactive region
Chromatin State	Weak transcription;Enhancers;Flanking Active TSS
No. of Marker's Association Results	1 (Positive: 0; Negative: 1; Trend: 0)
Source	Literature

SNP related association results

Normal genetic study related association results (count: 1)

Reference	Phenotype	Statistical Values	Author Comments	Marker's Category
Pardini, M.,2012	PTSD	C/- compared with T/T: In TPBI subjects without vmPFC lesi...... C/- compared with T/T: In TPBI subjects without vmPFC lesions: P-value= 0.6. In the vmPFC lesion group: P-value= 0.09. More...	No significant difference in PTSD prevalence between genotyp...... No significant difference in PTSD prevalence between genotypes in both subjects. More...	Non-significant

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Association Results (Positive/Negative/Trend)
FAAH	fatty acid amide hydrolase	1p35-p34	8(3/5/0)

SNPs in LD with rs3766246 (count: 8)

The LD data used here is based on 1000 Genome Phase I. LD SNP pairs were selected with a threshold r²<=0.8.


rs_ID	Annotation	No. of Association Results(Positive/Negative/Trend)	r²[population]
rs2295633	downstream_gene_variant(ENST00000468718); upstream_gene_variant(ENST00000493636); intron_variant(ENST00000484697, ENST00000493735, ENST00000489366, ENST00000243167); NMD_transcript_variant(ENST00000484697); non_coding_transcript_variant(ENST00000493735, ENST00000489366)	4(2/2/0)	0.8937[EUR]

rs_ID	Literature-origin SNPs with LD	Annotation	r²[population]
rs10789489	rs2295633 rs3766246	downstream_gene_variant; upstream_gene_variant; intron_variant; non_coding_transcript_variant	0.9102[EUR]
rs10890390	rs3766246	downstream_gene_variant	0.8592[EUR]
rs61784641	rs2295633 rs3766246	downstream_gene_variant	0.9106[EUR]
rs55852959	rs2295633 rs3766246	upstream_gene_variant	0.9102[EUR]
rs4141964	rs2295633 rs3766246	intron_variant; non_coding_transcript_variant	1.0000[EUR]
rs55646923	rs2295633 rs3766246	downstream_gene_variant	0.9323[EUR]
rs6697851	rs2295633 rs3766246	downstream_gene_variant; upstream_gene_variant; intron_variant; NMD_transcript_variant; non_coding_transcript_variant	0.9602[EUR]

SNP related eQTL (count: 1)

Gene Symbol	Gene Existed in PTSDgene?	Tissue	Trans/Cis	Source
CRHR1	Yes	Adipose Subcutaneous	cis	GTEx