PTSDgene database

SNP Report

Basic Info
Name rs7208505 dbSNP Ensembl
Location 17:59110368 - 59110368(+)
Variant Seq A
Ancestral Allele A
Ref Seq G
Minor Allele Frequence 0.408347
Annotation downstream_gene_variant; upstream_gene_variant; 3_prime_UTR_variant; intron_variant; non_coding_transcript_variant
Variant Effect downstream_gene_variant(ENST00000583976, ENST00000578519, ENST00000437036, ENST00000583927, ENST00000578105, ENST00000580541, ENST00000581068, ENST00000583380); upstream_gene_variant(ENST00000393066, ENST00000583387, ENST00000580122, ENST00000584889, ENST00000625984, ENST00000262294, ENST00000580973, ENST00000393065, ENST00000580620, ENST00000577554); 3_prime_UTR_variant(ENST00000330137); intron_variant(ENST00000451775); non_coding_transcript_variant(ENST00000451775)
SIFT Annotation tolerated
SIFT Variant Effect tolerated(ENST00000578105, ENST00000583380, ENST00000330137)
PolyPhen Annotation possibly_damaging
PolyPhen Variant Effect possibly_damaging(ENST00000578105, ENST00000583380, ENST00000330137)
rSNP? Yes Link in rVarBase
Related Regulatory Elements CpG island;Chromatin interactive region
Chromatin State Weak transcription;Strong transcription;Enhancers
No. of Marker's Association Results 2 (Positive: 0; Negative: 2; Trend: 0)
Source Literature

SNP related association results
Normal genetic study related association results (count: 2)
Reference Phenotype Statistical Values Author Comments Marker's Category
Sadeh, N.,2016 PTSD diagnosis Wald X2<0.99,P-value>0.32 Wald X2<0.99,P-value>0.32 SKA2 genotype was also not a significant predictor of PTSD d...... SKA2 genotype was also not a significant predictor of PTSD diagnosis. More... Non-significant
Sadeh, N.,2016 PTSD symptoms B<0.05,P-value>0.66 B<0.05,P-value>0.66 SKA2 genotype was also not a significant predictor of PTSD s...... SKA2 genotype was also not a significant predictor of PTSD symptoms. More... Non-significant

SNP related genes (count: 4)
Approved Symbol Approved Name Location No. of Association Results (Positive/Negative/Trend)
TRIM37 tripartite motif containing 37 17q22 Mapped by Literature SNP, Mapped by LD-proxy, rSNP target
TUBD1 tubulin delta 1 17q23.1 rSNP target
SKA2 spindle and kinetochore associated complex subunit 2 17q23.2 2(0/2/0)
VMP1 vacuole membrane protein 1 17q23.1 rSNP target

SNPs in LD with rs7208505 (count: 25)
The LD data used here is based on 1000 Genome Phase I. LD SNP pairs were selected with a threshold r2<=0.8.

Literature-origin SNPs (count: 0)

LD-proxies (count: 25)

SNP related eQTL (count: 1)
Gene Symbol Gene Existed in PTSDgene? Tissue Trans/Cis Source
CRHR1 Yes Adipose Subcutaneous cis GTEx