SNP Report
Basic Info
| Name | rs182455 dbSNP Ensembl | ||
|---|---|---|---|
| Location | 1:25908492 - 25908492(+) | ||
| Variant Seq | G | ||
| Ancestral Allele | G | ||
| Ref Seq | A | ||
| Minor Allele Frequence | 0.361422 | ||
| Annotation | upstream_gene_variant | ||
| Variant Effect | upstream_gene_variant(ENST00000465604, ENST00000374291, ENST00000580971, ENST00000446334, ENST00000584862, ENST00000357865, ENST00000455785, ENST00000485226, ENST00000399728, ENST00000426559) | ||
| SIFT Annotation | deleterious | ||
| SIFT Variant Effect | deleterious(ENST00000374291, ENST00000357865, ENST00000455785, ENST00000426559, ENST00000446334, ENST00000399728) | ||
| PolyPhen Annotation | benign | ||
| PolyPhen Variant Effect | benign(ENST00000374291, ENST00000357865, ENST00000455785, ENST00000426559, ENST00000446334, ENST00000399728) | ||
| rSNP? | Yes Link in rVarBase | ||
| Related Regulatory Elements | TF binding region;Chromatin interactive region | ||
| Chromatin State | Weak transcription;Enhancers | ||
| No. of Marker's Association Results | 5 (Positive: 1; Negative: 4; Trend: 0) | ||
| Source | Literature | ||
SNP related association results
| Reference | Phenotype | Statistical Values | Author Comments | Marker's Category |
|---|---|---|---|---|
| Cao, C.,2013 | Anxious arousal symptoms | In females: t=1.499, P-value=0.135, in males: t=-1.418, P-...... In females: t=1.499, P-value=0.135, in males: t=-1.418, P-value=0.160. More... | No significant relationship. No significant relationship. | Non-significant |
| Cao, C.,2013 | Avoidance symptoms | In females: t=1.010, P-value=0.314, in males: t=-0.460, P-...... In females: t=1.010, P-value=0.314, in males: t=-0.460, P-value=0.647. More... | No significant relationship. No significant relationship. | Non-significant |
| Cao, C.,2013 | Dysphoric arousal symptoms | In females: t=0.687, P-value=0.493, in males: t=-1.863, P-...... In females: t=0.687, P-value=0.493, in males: t=-1.863, P-value=0.066. More... | No significant relationship. No significant relationship. | Non-significant |
| Cao, C.,2013 | Emotional numbing symptoms | In females: t=0.304, P-value=0.761, in males: t=-1.489, P-...... In females: t=0.304, P-value=0.761, in males: t=-1.489, P-value=0.140. More... | No significant relationship. No significant relationship. | Non-significant |
| Cao, C.,2013 | Reexperiencing symptoms | In females: t=2.813, P-value=0.005, in males: t=0.139, P-v...... In females: t=2.813, P-value=0.005, in males: t=0.139, P-value=0.890. More... | The STMN1 rs182455 C-allelewas only significantly associated...... The STMN1 rs182455 C-allelewas only significantly associated with reexperiencing symptoms in females, but not males. More... | Significant |
SNP related genes (count: 3)
| Approved Symbol | Approved Name | Location | No. of Association Results (Positive/Negative/Trend)  |
|---|---|---|---|
| PAQR7 | progestin and adipoQ receptor family member VII | 1p35.3 | Mapped by LD-proxy, rSNP target |
| STMN1 | stathmin 1 | 1p36.11 | 6(1/5/0) |
| EXTL1 | exostosin-like glycosyltransferase 1 | 1p36.1 | rSNP target |
SNPs in LD with rs182455 (count: 44)
Literature-origin SNPs (count: 0)
LD-proxies (count: 44)
SNP related eQTL (count: 1)