Study Report
Study Information
Basic Info
| Reference |
Cao, C.,2013 PMID: 23583473
|
| Citation |
Cao, C., et al. (2013). "Stathmin genotype is associated with reexperiencing symptoms of posttraumatic stress disorder in Chinese earthquake survivors." Prog Neuropsychopharmacol Biol Psychiatry 44: 296-300. |
| Phenotype |
Reexperiencing symptoms, Avoidance symptoms, Emotional numbing symptoms, Dsyphoric arousal symptoms, Anxious arousal symptoms |
| Trauma |
Lost their children during the 2008 Wenchuan earthquake. |
| Study Design |
Cross-sectional study |
| Study Type |
Candidate gene association study |
| Sample Size |
320 samples |
| SNP/Marker Size |
1 SNP |
| Predominant Ethnicity |
Mongloid |
| Population |
145 (45.3%) Han, 168 (52.5%) Qiang, and 7 (2.2%) other ethnicities in China |
| Gender |
226 females, 94 males |
| Age |
Mean age=44.9 years, SD=11.6 |
Detail Info
| Sample Diagnosis |
DSM-IV |
| Related Diagnostic Tools |
All participants were visited and interviewed in their own house by trained investigators. The 17-item PTSD Checklist (PCL). |
| Sample Status |
None |
| Controls Exposed |
NA |
| Replication Size |
None |
| Result Summary |
Our results indicated that the STMN1 rs182455 genotype was not associated with severity of total PTSD symptoms in either females ormales; however, it could significantly predict severity of PTSD's reexperiencing symptoms in females. |
| Potential Biomarker |
None |
Genetic result reported by this study
Normal genetic result reported by this study (count: 5)
| Marker |
Phenotype |
Related Gene |
Statistical Values |
Author Comments |
Marker's Category |
|
rs182455
|
Avoidance symptoms |
STMN1 |
In females: t=1.010, P-value=0.314, in males: t=-0.460, P-value=0.647. |
No significant relationship.
No significant relationship.
|
Non-significant |
|
rs182455
|
Emotional numbing symptoms |
STMN1 |
In females: t=0.304, P-value=0.761, in males: t=-1.489, P-value=0.140. |
No significant relationship.
No significant relationship.
|
Non-significant |
|
rs182455
|
Anxious arousal symptoms |
STMN1 |
In females: t=1.499, P-value=0.135, in males: t=-1.418, P-value=0.160. |
No significant relationship.
No significant relationship.
|
Non-significant |
|
rs182455
|
Reexperiencing symptoms |
STMN1 |
In females: t=2.813, P-value=0.005, in males: t=0.139, P-value=0.890. |
The STMN1 rs182455 C-allelewas only significantly associated......
The STMN1 rs182455 C-allelewas only significantly associated with reexperiencing symptoms in females, but not males.
More...
|
Significant |
|
rs182455
|
Dysphoric arousal symptoms |
STMN1 |
In females: t=0.687, P-value=0.493, in males: t=-1.863, P-value=0.066. |
No significant relationship.
No significant relationship.
|
Non-significant |
