Gene Report

Basic Info

Approved Symbol	CHRNB4
Approved Name	cholinergic receptor, nicotinic beta 4
Previous Name	"cholinergic receptor, nicotinic, beta polypeptide 4\|cholinergic receptor, nicotinic, beta 4 (neuronal)"
Name Alias	acetylcholine receptor, nicotinic, beta 4 (neuronal)
Location	15q24
Position	chr15:78624119-78727754, -1
External Links	HGNC: 1964 Entrez Gene: 1143 Ensembl: ENSG00000117971 UCSC: uc002bed.1
No. of Association Results	0. Gene is from "Mapped by Literature SNP, Mapped by LD-proxy, rSNP target"
Annotation Type	Mapped by Literature SNP, Mapped by LD-proxy, rSNP target

Gene functional annotation

Gene related GO terms (count: 30)

ID	Name	Type	Evidence[PMID]	No. of Genes in PTSDgene
GO:0060084	synaptic transmission involved in micturition	biological process	IMP[11450844]	2
GO:0030054	cell junction	cellular component	IEA	24
GO:0006940	regulation of smooth muscle contraction	biological process	IEA	2
GO:0007626	locomotory behavior	biological process	IEA	9
GO:0042166	acetylcholine binding	molecular function	IBA	8
GO:0005886	plasma membrane	cellular component	TAS	99
GO:0034220	ion transmembrane transport	biological process	TAS[20438829]	9
GO:0035095	behavioral response to nicotine	biological process	IEA	4
GO:0046928	regulation of neurotransmitter secretion	biological process	NAS[11742001]	2
GO:0016021	integral component of membrane	cellular component	NAS[8906617]	56
GO:0006811	ion transport	biological process	TAS[8906617]	10
GO:0035094	response to nicotine	biological process	IBA	11
GO:0001508	action potential	biological process	IEA	3
GO:0051971	positive regulation of transmission of nerve impulse	biological process	IEA	1
GO:0006939	smooth muscle contraction	biological process	IEA	1
GO:0098655	cation transmembrane transport	biological process	IEA; TAS[8906617\|11742001\|20438829]	8
GO:0005887	integral component of plasma membrane	cellular component	IC[11742001]	36
GO:0008144	drug binding	molecular function	IEA	13
GO:0046982	protein heterodimerization activity	molecular function	IEA	10
GO:0005892	acetylcholine-gated channel complex	cellular component	IDA[8906617]; TAS[11742001]	8
GO:0007268	synaptic transmission	biological process	TAS	32
GO:0015464	acetylcholine receptor activity	molecular function	IDA[8906617]	8
GO:0051291	protein heterooligomerization	biological process	IEA	4
GO:0043005	neuron projection	cellular component	IEA	17
GO:0015276	ligand-gated ion channel activity	molecular function	TAS[20438829]	4
GO:0007165	signal transduction	biological process	IDA[8906617]	34
GO:0007271	synaptic transmission, cholinergic	biological process	TAS[1330682]	9
GO:0004889	acetylcholine-activated cation-selective channel activity	molecular function	TAS[8906617\|11742001\|20438829]	8
GO:0099565	chemical synaptic transmission, postsynaptic	biological process	IDA[8906617]	7
GO:0045211	postsynaptic membrane	cellular component	IEA	21

Gene related KEGG pathways (count: 0)

Gene related interactors from protein-protein interactions data in PINA v2 (count: 4)

Gene	Interactor	Interactor in PTSDgene?	Experiment Method	Interaction Type	PMID
CHRNB4	CHRNA2	Yes	--	--	8906617
CHRNB4	CHRNA4	Yes	--	--	8906617
CHRNB4	UBQLN1	No	--	--	16091357
CHRNB4	CHRNA3	Yes	--	--	1725184