PTSDgene database

Pathway Enrichment Analysis Protein-Protein Interaction Analysis

Study Report

Study Information

Basic Info

Reference	Liu, Y.,2013 PMID: 24839585
Citation	Liu, Y., et al. (2013). "Association of Variant rs4790904 in Protein Kinase C Alpha with Posttraumatic Stress Disorder in a U.S. Caucasian and African-American Veteran Sample." J Depress Anxiety 2(1): S4001.
Phenotype	Total PTSD symptoms, PTSD diagnosis, PTSD category B symptom score, PTSD category C symptom score, PTSD category D symptom score
Trauma	Various
Study Design	Case-control
Study Type	Candidate gene association study
Sample Size	391 cases, 570 controls
SNP/Marker Size	1 SNP
Predominant Ethnicity	Black, Caucasian
Population	428 Caucasians and 533 African-Americans
Gender	Caucasians: 15% females, African-Americans: 31% females
Age	Caucasians: mean age= 35 years, African-Americans: mean age= 41 years

Detail Info

Genetic result reported by this study

Normal genetic result reported by this study (count: 5)

Marker	Phenotype	Related Gene	Statistical Values	Author Comments	Marker's Category
rs4790904	PTSD diagnosis	PRKCA	Caucasian samples: P-value=0.37; african american samples: P-value=0.046	We found a significant association between the categorical g...... We found a significant association between the categorical genotype of SNP rs4790904 with current PTSD diagnosis in the African-Americans, but not the Caucasians. More...	Significant
rs4790904	PTSD category B symptom score	PRKCA	Caucasian samples: spearman correlation P-value=0.045; african american samples: P-value>0.05	SNP rs4790905 was significantly associated with PTSD B sympt...... SNP rs4790905 was significantly associated with PTSD B symptoms in the Caucasian samples including both current PTSD cases and controls, but not the African-American samples. More...	Significant
rs4790904	PTSD category C symptom score	PRKCA	Caucasian samples: spearman correlation P-value=0.016; african american samples: P-value>0.05	SNP rs4790906 was significantly associated with PTSD C sympt...... SNP rs4790906 was significantly associated with PTSD C symptoms in the Caucasian samples including both current PTSD cases and controls, but not the African-American samples. More...	Significant
rs4790904	PTSD category D symptom score	PRKCA	Caucasian samples: spearman correlation P-value=0.017; african american samples: P-value>0.05	SNP rs4790907 was significantly associated with PTSD D sympt...... SNP rs4790907 was significantly associated with PTSD D symptoms in the Caucasian samples including both current PTSD cases and controls, but not the African-American samples. More...	Significant
rs4790904	Total PTSD symptoms	PRKCA	Caucasian samples: spearman correlation P-value=0.02; african american samples: P-value>0.05	SNP rs4790904 was significantly associated with total PTSD s...... SNP rs4790904 was significantly associated with total PTSD symptoms in the Caucasian samples including both current PTSD cases and controls, but not the African-American samples. More...	Significant