Gene Report

Basic Info

Approved Symbol	TP53
Symbol Alias	"p53\|LFS1"
Approved Name	tumor protein p53
Name Alias	Li-Fraumeni syndrome
Location	17p13.1
Position	chr17:7661779-7687550, -1
External Links	HGNC: 11998 Entrez Gene: 7157 Ensembl: ENSG00000141510 UCSC: uc002gij.3
No. of Association Results	0. Gene is from "rSNP target"
Annotation Type	rSNP target

Gene functional annotation

Gene related GO terms (count: 161)

ID	Name	Type	Evidence[PMID]	No. of Genes in PTSDgene
GO:0002326	B cell lineage commitment	biological process	IEA	1
GO:0003677	DNA binding	molecular function	IMP[2144364]	13
GO:2001244	positive regulation of intrinsic apoptotic signaling pathway	biological process	IMP[14963330]	1
GO:0006284	base-excision repair	biological process	TAS[15116721]	2
GO:0034644	cellular response to UV	biological process	IBA	1
GO:0000790	nuclear chromatin	cellular component	IDA[15710329\|17805299\|22521434]	5
GO:0071850	mitotic cell cycle arrest	biological process	IEA	1
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	biological process	IDA[11672523\|16131611\|17599062\|18549481\|20959462\|24652652]; IGI[16061649]; IMP[17146433]	25
GO:0035033	histone deacetylase regulator activity	molecular function	IEA	1
GO:0001046	core promoter sequence-specific DNA binding	molecular function	ISS	2
GO:0007219	Notch signaling pathway	biological process	TAS	4
GO:0045892	negative regulation of transcription, DNA-templated	biological process	IDA[24051492]; ISS[19749791]	5
GO:0019901	protein kinase binding	molecular function	IPI[11546806\|21317932]	4
GO:0043234	protein complex	cellular component	IDA[9529249]	10
GO:0035794	positive regulation of mitochondrial membrane permeability	biological process	IEA	2
GO:0031065	positive regulation of histone deacetylation	biological process	IBA	1
GO:0005657	replication fork	cellular component	IBA	2
GO:0046982	protein heterodimerization activity	molecular function	IPI[10837489]	10
GO:0048512	circadian behavior	biological process	ISS	1
GO:0005730	nucleolus	cellular component	IDA[12080348]	9
GO:0035035	histone acetyltransferase binding	molecular function	IPI[9194565\|10518217]	2
GO:0008340	determination of adult lifespan	biological process	ISS	3
GO:0090200	positive regulation of release of cytochrome c from mitochondria	biological process	IDA[12667443\|14963330]	1
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	molecular function	IDA[24652652]	2
GO:0046902	regulation of mitochondrial membrane permeability	biological process	TAS[15116721]	1
GO:0030330	DNA damage response, signal transduction by p53 class mediator	biological process	IDA[15149599]; IMP[20160708]	2
GO:0007050	cell cycle arrest	biological process	IDA[15149599]; IMP[7958916\|10962037]	4
GO:0072363	regulation of glycolytic process by positive regulation of transcription from RNA polymerase II promoter	biological process	IEA	1
GO:2000378	negative regulation of reactive oxygen species metabolic process	biological process	IEA	1
GO:0012501	programmed cell death	biological process	TAS	4
GO:0035690	cellular response to drug	biological process	IEP[20810912]	6
GO:0001228	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding	molecular function	IDA[17146433]	4
GO:1901525	negative regulation of macromitophagy	biological process	IEA	1
GO:0043065	positive regulation of apoptotic process	biological process	IDA[12667443\|20959462]	12
GO:0003682	chromatin binding	molecular function	IDA[16322561\|17599062]	6
GO:0016363	nuclear matrix	cellular component	IDA[11080164]	3
GO:0007596	blood coagulation	biological process	TAS	11
GO:0006461	protein complex assembly	biological process	IDA[12915590]	6
GO:0042149	cellular response to glucose starvation	biological process	IDA[14744935\|21471221]	1
GO:0007179	transforming growth factor beta receptor signaling pathway	biological process	IEA	3
GO:0030308	negative regulation of cell growth	biological process	IMP[8986812]	2
GO:0005515	protein binding	molecular function	IPI[1465435\|7663514\|7799929\|8207801\|8344494\|8675009\|8875926\|8875929\|9050995\|9188558\|9194564\|9194565\|9380510\|9472015\|9529249\|9807817\|9827557\|10196247\|10226625\|10518217\|10597287\|10608892\|10823891\|11080164\|11146555\|11178989\|11359905\|11388671\|11427532\|11672523\|11684014\|11706030\|11877378\|11950834\|12006491\|12080348\|12620801\|12667443\|12702766\|12730672\|12750254\|12915590\|14557665\|14627987\|14744935\|14963330\|14976264\|14985081\|15044383\|15068796\|15133049\|15144954\|15205477\|15310821\|15364927\|15525938\|15542844\|15604276\|15660129\|15710329\|15735003\|15735006\|15782130\|15855171\|15916963\|15960975\|15989956\|16003391\|16151013\|16169070\|16227626\|16322561\|16376338\|16376884\|16377624\|16415881\|16442532\|16458891\|16474402\|16493710\|16601686\|16611888\|16616141\|16690937\|16753148\|16845383\|16847267\|16951253\|16959611\|17098746\|17108971\|17139261\|17159902\|17170702\|17184779\|17245430\|17254968\|17268548\|17274640\|17290220\|17298945\|17310983\|17317671\|17347673\|17482142\|17568776\|17612295\|17662718\|17707234\|17719541\|17719542\|17805299\|17875722\|17906639\|17964266\|18087040\|18230339\|18235501\|18309296\|18354501\|18388957\|18485870\|18504427\|18510931\|18566590\|18624398\|18656471\|18812399\|18977328\|19008854\|19043414\|19098711\|19151705\|19166840\|19234109\|19339993\|19345189\|19411066\|19483087\|19508870\|19521340\|19536131\|19556538\|19619542\|19656744\|19680552\|19740107\|19798103\|19833129\|19857493\|19933256\|20075864\|20096447\|20118233\|20123734\|20124405\|20153329\|20159018\|20167603\|20206173\|20227041\|20228809\|20385133\|20452352\|20515689\|20562916\|20591429\|20622899\|20705607\|20708156\|20713054\|20818423\|20864041\|20959462\|21057547\|21081126\|21130767\|21132010\|21170034\|21170087\|21317932\|21423215\|21460856\|21471221\|21513714\|21625211\|21726810\|21741598\|21821029\|21900206\|21952639\|21988832\|22085928\|22103682\|22124327\|22265415\|22340593\|22510990\|22575647\|22653443\|22659184\|22726440\|22810585\|22819825\|22945289\|22975381\|23010591\|23092970\|23320542\|23431171\|23576507\|23623661\|23734815\|23752197\|23776060\|23870121\|24219989\|24449765\|24492002\|25241761\|25314079\|25402006\|25609649\|25670079]	169
GO:0002020	protease binding	molecular function	IPI[11923872]	4
GO:2000772	regulation of cellular senescence	biological process	IEA	1
GO:0002931	response to ischemia	biological process	IEA	1
GO:0035861	site of double-strand break	cellular component	IEA	2
GO:0005654	nucleoplasm	cellular component	IDA[11080164\|12915590]; TAS	43
GO:0005669	transcription factor TFIID complex	cellular component	IDA[15053879]	1
GO:0033077	T cell differentiation in thymus	biological process	IEA	1
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	biological process	ISS[19749791]	4
GO:0043621	protein self-association	molecular function	IPI[14985081]	1
GO:0010165	response to X-ray	biological process	IBA	1
GO:0003690	double-stranded DNA binding	molecular function	IBA	1
GO:0009303	rRNA transcription	biological process	IEA	1
GO:0048147	negative regulation of fibroblast proliferation	biological process	IMP[10962037]	3
GO:0097252	oligodendrocyte apoptotic process	biological process	IDA[7720704]	1
GO:0001077	transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding	molecular function	IEA	2
GO:0051721	protein phosphatase 2A binding	molecular function	IPI[17245430]	3
GO:0000060	protein import into nucleus, translocation	biological process	IEA	3
GO:0090403	oxidative stress-induced premature senescence	biological process	IMP[19951988]	1
GO:0007569	cell aging	biological process	IMP[12080348]	2
GO:0002309	T cell proliferation involved in immune response	biological process	IEA	1
GO:0051097	negative regulation of helicase activity	biological process	TAS[7663514]	1
GO:0010666	positive regulation of cardiac muscle cell apoptotic process	biological process	IEA	1
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	biological process	IEA	2
GO:0005737	cytoplasm	cellular component	IDA[7720704\|14744935\|15340061\|16131611\|20096447\|20810912]	109
GO:0006983	ER overload response	biological process	IDA[14744935]	1
GO:0006281	DNA repair	biological process	TAS	8
GO:0010467	gene expression	biological process	TAS	16
GO:0060411	cardiac septum morphogenesis	biological process	IEA	1
GO:1904024	negative regulation of glucose catabolic process to lactate via pyruvate	biological process	IEA	1
GO:0043504	mitochondrial DNA repair	biological process	IEA	1
GO:0005829	cytosol	cellular component	IDA[14963330\|24101517]	78
GO:0005634	nucleus	cellular component	IDA[7720704\|14744935\|14963330\|15340061\|16131611\|16322561\|16507995\|17403783\|18756595\|19234109\|20096447\|20810912\|24101517]	81
GO:0034103	regulation of tissue remodeling	biological process	IEA	1
GO:0031497	chromatin assembly	biological process	IDA[16322561]	1
GO:0071479	cellular response to ionizing radiation	biological process	IMP[20160708]	1
GO:0034613	cellular protein localization	biological process	IDA[15340061]	1
GO:0005759	mitochondrial matrix	cellular component	IEA	6
GO:0071494	cellular response to UV-C	biological process	IEA	1
GO:0043565	sequence-specific DNA binding	molecular function	IBA	5
GO:0031625	ubiquitin protein ligase binding	molecular function	IPI[8875929\|9529249\|10415337\|17121812\|18382127]	6
GO:0002360	T cell lineage commitment	biological process	IEA	1
GO:0090399	replicative senescence	biological process	IMP[19951988]	1
GO:0051087	chaperone binding	molecular function	IPI[18086682]	1
GO:0006302	double-strand break repair	biological process	TAS	3
GO:0031052	chromosome breakage	biological process	IEA	1
GO:0045861	negative regulation of proteolysis	biological process	IEA	1
GO:0010332	response to gamma radiation	biological process	IMP[7958916]	3
GO:0007275	multicellular organism development	biological process	IMP[10065150]	9
GO:0016032	viral process	biological process	IMP[22574148]	8
GO:0097193	intrinsic apoptotic signaling pathway	biological process	TAS[16462759]	2
GO:0051262	protein tetramerization	biological process	TAS[15116721]	6
GO:0030971	receptor tyrosine kinase binding	molecular function	IPI[23027130]	1
GO:2000379	positive regulation of reactive oxygen species metabolic process	biological process	IMP[20160708]	1
GO:0005507	copper ion binding	molecular function	IDA[7824276]	3
GO:0007406	negative regulation of neuroblast proliferation	biological process	IEA	2
GO:0006355	regulation of transcription, DNA-templated	biological process	IDA[7587074]	14
GO:0035264	multicellular organism growth	biological process	IEA	1
GO:0019899	enzyme binding	molecular function	IPI[7663514\|10666337\|11672523\|11781842\|15044383\|15577914\|17805299\|20173098]	13
GO:0006367	transcription initiation from RNA polymerase II promoter	biological process	TAS	5
GO:0070266	necroptotic process	biological process	IEA	2
GO:0019903	protein phosphatase binding	molecular function	IPI[20562916]	2
GO:1900740	positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway	biological process	TAS	1
GO:0002039	p53 binding	molecular function	IBA	2
GO:0061419	positive regulation of transcription from RNA polymerase II promoter in response to hypoxia	biological process	IEA	1
GO:0007369	gastrulation	biological process	IEA	1
GO:0072332	intrinsic apoptotic signaling pathway by p53 class mediator	biological process	IMP[12172011\|16322561]	2
GO:0042981	regulation of apoptotic process	biological process	IDA[14744935]	3
GO:0006974	cellular response to DNA damage stimulus	biological process	IDA[14744935\|15710329\|17938203]	5
GO:0008134	transcription factor binding	molecular function	IPI[15053879\|15705871\|19505873]	5
GO:1990144	intrinsic apoptotic signaling pathway in response to hypoxia	biological process	IEA	1
GO:0043525	positive regulation of neuron apoptotic process	biological process	IBA	3
GO:0000733	DNA strand renaturation	biological process	IDA[8183576]	2
GO:0008283	cell proliferation	biological process	TAS[10065150]	9
GO:0001756	somitogenesis	biological process	IEA	1
GO:0001836	release of cytochrome c from mitochondria	biological process	IEA	3
GO:0070245	positive regulation of thymocyte apoptotic process	biological process	ISS	1
GO:0044212	transcription regulatory region DNA binding	molecular function	IDA[15710329\|16131611\|17996705]	4
GO:1902108	regulation of mitochondrial membrane permeability involved in apoptotic process	biological process	IEA	1
GO:1900119	positive regulation of execution phase of apoptosis	biological process	IMP[14985081]	1
GO:0042802	identical protein binding	molecular function	IPI[14985081\|16291740\|17612295\|19339993\|21522129\|21988832\|22653443\|25402006\|25609649]	10
GO:0016605	PML body	cellular component	IDA[12006491\|22869143]	1
GO:0071158	positive regulation of cell cycle arrest	biological process	IMP[21471221]	1
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding	molecular function	IEA	1
GO:2000269	regulation of fibroblast apoptotic process	biological process	IEA	1
GO:0006289	nucleotide-excision repair	biological process	IMP[7663514]	1
GO:0005783	endoplasmic reticulum	cellular component	IEA	20
GO:0046677	response to antibiotic	biological process	IEP[20810912]	2
GO:0008270	zinc ion binding	molecular function	TAS[10065153]	26
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	biological process	TAS	4
GO:0043066	negative regulation of apoptotic process	biological process	IDA[16131611]; IMP[20124405]	9
GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	biological process	IDA[14654789\|14744935\|17403783]	1
GO:0007265	Ras protein signal transduction	biological process	IEP[9054499]	8
GO:0001085	RNA polymerase II transcription factor binding	molecular function	IPI[18549481]	3
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	biological process	IDA[15340061]; ISS[19749791]	16
GO:0003684	damaged DNA binding	molecular function	IBA	3
GO:0032461	positive regulation of protein oligomerization	biological process	IDA[12667443]	2
GO:0006978	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	biological process	IMP[7958916]	2
GO:0006915	apoptotic process	biological process	TAS	19
GO:0051974	negative regulation of telomerase activity	biological process	IDA[10597287]	1
GO:0008104	protein localization	biological process	IDA[16507995]	4
GO:0005739	mitochondrion	cellular component	IDA[12667443\|24101517]	29
GO:0043153	entrainment of circadian clock by photoperiod	biological process	ISS	1
GO:0048568	embryonic organ development	biological process	IEA	1
GO:0021549	cerebellum development	biological process	IEA	3
GO:1902253	regulation of intrinsic apoptotic signaling pathway by p53 class mediator	biological process	IEA	1
GO:0030154	cell differentiation	biological process	TAS[10065150]	10
GO:0031571	mitotic G1 DNA damage checkpoint	biological process	IMP[7958916]	1
GO:0071456	cellular response to hypoxia	biological process	IEP[20810912]	4
GO:0008285	negative regulation of cell proliferation	biological process	IDA[22783376]; IMP[12730672]; ISS	13
GO:0016604	nuclear body	cellular component	IDA[10360174]	1
GO:0003700	transcription factor activity, sequence-specific DNA binding	molecular function	IDA[7587074\|18549481]	9
GO:0045893	positive regulation of transcription, DNA-templated	biological process	IDA[16322561\|17403783\|18549481\|20378837]; IMP[20096447]	11
GO:0005524	ATP binding	molecular function	IDA[8183576]	23
GO:0051402	neuron apoptotic process	biological process	IEA	2
GO:0009651	response to salt stress	biological process	IEA	3
GO:0001701	in utero embryonic development	biological process	IEA	3
GO:0047485	protein N-terminus binding	molecular function	IPI[11861836]	2
GO:0010628	positive regulation of gene expression	biological process	IDA[20332243]	14
GO:1990440	positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress	biological process	ISS	1

Gene related KEGG pathways (count: 19)

ID	Name	No. of Genes in PTSDgene
hsa05222	Small cell lung cancer	5
hsa05219	Bladder cancer	1
hsa05220	Chronic myeloid leukemia	2
hsa05217	Basal cell carcinoma	1
hsa05218	Melanoma	2
hsa04010	MAPK signaling pathway	13
hsa05215	Prostate cancer	3
hsa05216	Thyroid cancer	2
hsa04115	p53 signaling pathway	2
hsa05223	Non-small cell lung cancer	3
hsa04110	Cell cycle	1
hsa04210	Apoptosis	6
hsa05040	Huntington's disease	4
hsa05030	Amyotrophic lateral sclerosis (ALS)	3
hsa04310	Wnt signaling pathway	2
hsa05212	Pancreatic cancer	3
hsa05214	Glioma	3
hsa05213	Endometrial cancer	2
hsa05210	Colorectal cancer	2

Gene related interactors from protein-protein interactions data in PINA v2 (count: 0)