Study Report
Study Information
Basic Info
| Reference |
Svob Strac, D.,2016 PMID: 27112218
|
| Citation |
Svob Strac, D., et al. (2016). "Platelet monoamine oxidase type B, MAOB intron 13 and MAOA-uVNTR polymorphism and symptoms of post-traumatic stress disorder." Stress 19(4): 362-373. |
| Phenotype |
PTSD symptom severity, CAPS scores |
| Trauma |
Combat |
| Study Design |
Cross-sectional study |
| Study Type |
Candidate gene association study |
| Sample Size |
249 samples |
| SNP/Marker Size |
1 SNP, 1 VNTR |
| Predominant Ethnicity |
Caucasian |
| Population |
Croatian |
| Gender |
249 males, 0 females |
| Age |
Mean age=43.8 years,SD=7.2 |
Detail Info
| Sample Diagnosis |
DSM-IV |
| Related Diagnostic Tools |
Structured Clinical Interview (SCID), Clinician Administered PTSD Scale (CAPS), Positive and Negative Syndrome Scale (PANSS) |
| Sample Status |
The study included 249 male participants, veterans with real combat experience, who developed chronic and current combat related PTSD. Exclusion criteria included earlier history of acute psychosis, dementia, cognitive dyssfunction, mental retardation, schizophrenia, mood disorders, personality disorders, substance abuse, past or current alcohol or other substance abuse within 3 months. |
| Controls Exposed |
NA |
| Replication Size |
None |
| Result Summary |
A marginally significant association was found between MAOB rs1799836 polymorphism and severity of PTSD symptoms, but it was not confirmed since carriers of G or A allele of MAOB rs1799836 did not differ in their total CAPS scores. These findings suggest an association of platelet MAO-B activity, but a lack of association of MAOB rs1799836 and MAOA-uVNTR, with selected psychotic symptoms in ethnically homogenous veterans with PTSD. |
| Potential Biomarker |
None |
Genetic result reported by this study
Normal genetic result reported by this study (count: 4)
| Marker |
Phenotype |
Related Gene |
Statistical Values |
Author Comments |
Marker's Category |
|
rs1799836
|
PTSD symptoms |
MAOB |
U=6530.0, P-value=0.336 |
Carriers of G or A allele of MAOB rs1799836 did not differ i......
Carriers of G or A allele of MAOB rs1799836 did not differ in their total CAPS scores.
More...
|
Non-significant |
|
rs1799836
|
PTSD symptom severity |
MAOB |
X2=6.176, df=2, P-value=0.046 |
A marginally significant association was found between MAOB ......
A marginally significant association was found between MAOB rs1799836 polymorphism and severity of PTSD symptoms.
More...
|
Significant |
|
MAOA-uVNTR
|
PTSD symptoms |
MAOA |
U=4208.0, P-value=0.388 |
No significant results were found between MAOA-uVNTR and PTS......
No significant results were found between MAOA-uVNTR and PTSD.
More...
|
Non-significant |
|
MAOA-uVNTR
|
PTSD symptom severity |
MAOA |
X2=2.017, df=2, P-value=0.365 |
No significant results were found between MAOA-uVNTR and PTS......
No significant results were found between MAOA-uVNTR and PTSD.
More...
|
Non-significant |
