Gene Report

Basic Info

Approved Symbol	MAOA
Approved Name	monoamine oxidase A
Location	Xp11.4-p11.3
Position	chrX:43654907-43746824, 1
External Links	HGNC: 6833 Entrez Gene: 4128 Ensembl: ENSG00000189221 UCSC: uc004dfy.4
No. of Association Results	2 (Positive: 0; Negative: 2; trend: 0)
Annotation Type	Literature-origin

Gene related association results

Normal genetic study related association results (count: 2)

Reference	Phenotype	Marker	Gene's Category
Svob Strac, D.,2016	PTSD symptom severity	MAOA-uVNTR	Non-significant
Svob Strac, D.,2016	PTSD symptoms	MAOA-uVNTR	Non-significant

Gene functional annotation

Gene related GO terms (count: 17)

ID	Name	Type	Evidence[PMID]	No. of Genes in PTSDgene
GO:0005741	mitochondrial outer membrane	cellular component	TAS[24252804]	4
GO:0042428	serotonin metabolic process	biological process	IEA	3
GO:0007268	synaptic transmission	biological process	TAS	32
GO:0006576	cellular biogenic amine metabolic process	biological process	TAS[8211186]	1
GO:0016021	integral component of membrane	cellular component	IEA	56
GO:0005739	mitochondrion	cellular component	IDA[20833797]	29
GO:0055114	oxidation-reduction process	biological process	IEA	18
GO:0008131	primary amine oxidase activity	molecular function	TAS	2
GO:0007269	neurotransmitter secretion	biological process	TAS	4
GO:0042443	phenylethylamine metabolic process	biological process	IEA	1
GO:0042135	neurotransmitter catabolic process	biological process	IEA	2
GO:0050660	flavin adenine dinucleotide binding	molecular function	IEA	5
GO:0006805	xenobiotic metabolic process	biological process	TAS	9
GO:0044281	small molecule metabolic process	biological process	TAS	38
GO:0042420	dopamine catabolic process	biological process	TAS[24252804]	5
GO:0042136	neurotransmitter biosynthetic process	biological process	TAS	5
GO:0051378	serotonin binding	molecular function	IEA	2

Gene related KEGG pathways (count: 7)

ID	Name	No. of Genes in PTSDgene
hsa00380	Tryptophan metabolism	6
hsa00220	Urea cycle and metabolism of amino groups	3
hsa00982	Drug metabolism - cytochrome P450	2
hsa00260	Glycine, serine and threonine metabolism	4
hsa00340	Histidine metabolism	2
hsa00350	Tyrosine metabolism	5
hsa00360	Phenylalanine metabolism	2

Gene related interactors from protein-protein interactions data in PINA v2 (count: 1)

Gene	Interactor	Interactor in PTSDgene?	Experiment Method	Interaction Type	PMID
MAOA	NDRG1	Yes	--	--	17220478 , 17220478 , 17220478