Gene Report

Basic Info

Approved Symbol	MAOB
Approved Name	monoamine oxidase B
Location	Xp11.4-p11.3
Position	chrX:43766611-43882447, -1
External Links	HGNC: 6834 Entrez Gene: 4129 Ensembl: ENSG00000069535 UCSC: uc004dfz.4
No. of Association Results	3 (Positive: 1; Negative: 2; trend: 0)
Annotation Type	Literature-origin, Mapped by Literature SNP

Gene related association results

Normal genetic study related association results (count: 3)

Reference	Phenotype	Marker	Gene's Category
Svob Strac, D.,2016	PTSD symptom severity	rs1799836	Significant
Svob Strac, D.,2016	PTSD symptoms	rs1799836	Non-significant
Pivac, N.,2007	PTSD	MAO-B_intron 13	Non-significant

Gene functional annotation

Gene related GO terms (count: 25)

ID	Name	Type	Evidence[PMID]	No. of Genes in PTSDgene
GO:0010044	response to aluminum ion	biological process	IEA	1
GO:0051412	response to corticosterone	biological process	IEA	3
GO:0044281	small molecule metabolic process	biological process	TAS	38
GO:0045471	response to ethanol	biological process	IEA	18
GO:0045964	positive regulation of dopamine metabolic process	biological process	IEA	1
GO:0050665	hydrogen peroxide biosynthetic process	biological process	NAS[24252804]	1
GO:0016021	integral component of membrane	cellular component	IEA	56
GO:0042803	protein homodimerization activity	molecular function	IEA	18
GO:0006805	xenobiotic metabolic process	biological process	TAS	9
GO:0042420	dopamine catabolic process	biological process	TAS[24252804]	5
GO:0010269	response to selenium ion	biological process	IEA	2
GO:0050660	flavin adenine dinucleotide binding	molecular function	IEA	5
GO:0009636	response to toxic substance	biological process	IEA	10
GO:0008131	primary amine oxidase activity	molecular function	TAS	2
GO:0005739	mitochondrion	cellular component	IDA[20833797]	29
GO:0009055	electron carrier activity	molecular function	TAS[8602220]	1
GO:0014063	negative regulation of serotonin secretion	biological process	IEA	1
GO:0042493	response to drug	biological process	IEA	25
GO:0055114	oxidation-reduction process	biological process	IEA	18
GO:0005743	mitochondrial inner membrane	cellular component	IEA	3
GO:0005741	mitochondrial outer membrane	cellular component	TAS[24252804]	4
GO:0032496	response to lipopolysaccharide	biological process	IEA	9
GO:0005740	mitochondrial envelope	cellular component	TAS[7063850]	1
GO:0021762	substantia nigra development	biological process	IEP[22926577]	1
GO:0070062	extracellular exosome	cellular component	IDA[23376485]	58

Gene related KEGG pathways (count: 7)

ID	Name	No. of Genes in PTSDgene
hsa00380	Tryptophan metabolism	6
hsa00220	Urea cycle and metabolism of amino groups	3
hsa00982	Drug metabolism - cytochrome P450	2
hsa00260	Glycine, serine and threonine metabolism	4
hsa00340	Histidine metabolism	2
hsa00350	Tyrosine metabolism	5
hsa00360	Phenylalanine metabolism	2

Gene related interactors from protein-protein interactions data in PINA v2 (count: 1)

Gene	Interactor	Interactor in PTSDgene?	Experiment Method	Interaction Type	PMID
MAOB	SRPK1	No	--	--	21988832 , 21988832