Study Report
Study Information
Basic Info
| Reference |
Guffanti, G.,2013 PMID: 24080187
|
| Citation |
Guffanti, G., et al. (2013). "Genome-wide association study implicates a novel RNA gene, the lincRNA AC068718.1, as a risk factor for post-traumatic stress disorder in women." Psychoneuroendocrinology 38(12): 3029-3038. |
| Phenotype |
PTSD |
| Trauma |
Various |
| Study Design |
Case-control |
| Study Type |
Genome-wide association study |
| Sample Size |
413 DNHS women:94 PTSD cases and 319 controls |
| SNP/Marker Size |
688,890 SNPs |
| Predominant Ethnicity |
Caucasian, Black |
| Population |
DNHS: 342 African Americans, 45 European Americans, 26 individuals of other ethnicity. NHSII: 98.1% white. |
| Gender |
all women |
| Age |
DNHS subjects: Cases: mean age=52.2 years, SD=13.5. Controls: mean age=54.3 years, SD=15.9. NHSII: mean age=53.3 years. |
Detail Info
| Sample Diagnosis |
DSM-IV |
| Related Diagnostic Tools |
DNHS subjects: PTSD diagnosis was assessed via structured interview administered via telephone (Breslau et al., 1998). The Clinician Administered PTSD Scale (CAPS) (Blake et al., 1995). NHSII subjects: Lifetime PTSD diagnosis was assessed in relation to participant's worst event via structured telephone interview similar to that used for the DNHS (Roberts et al., 2012). |
| Sample Status |
None |
| Controls Exposed |
Yes |
| Replication Size |
NHSII women:578 PTSD cases and 1963 controls |
| Result Summary |
We found genome-wide significant association for one marker mapping to a novel RNA gene, lincRNA AC068718.1, for which we found suggestive evidence of replication in NHSII. Our network-based analysis indicates that our top GWAS results were enriched for pathways related to telomere maintenance and immune function. Our findings implicate a novel RNA gene, lincRNA AC068718.1, as risk factor for PTSD in women and add to emerging evidence that non-coding RNA genes may play a crucial role in shaping the landscape of gene regulation with putative pathological effects that lead to phenotypic differences. |
| Potential Biomarker |
None |
Genetic result reported by this study
Normal genetic result reported by this study (count: 7)
| Marker |
Phenotype |
Related Gene |
Statistical Values |
Author Comments |
Marker's Category |
|
rs10170218
|
PTSD |
AC068718.1 |
In the DNHS subjects: B=5.45, P-value=5.10E-08, OR=2.89, 95%CI=1.97-4.23.The Bonferroni corrected P-value=0.035. In NHS-II sample: additive genetic model P-value=0.07, genotypic model P-value=0.03, dominant model P-value=0.01. |
The strongest signal was at SNP rs10170218 with a genome-wid......
The strongest signal was at SNP rs10170218 with a genome-wide significant p-value. And they found suggestive evidence of replication in NHSII.
More...
|
Significant |
|
rs7302717
|
PTSD |
TMCC3 |
In the DNHS subjects: B=-4.54, P-value=5.72E-06, OR=0.41, 95%CI=0.28-0.60. |
|
Trend |
|
rs2413187
|
PTSD |
LARGE |
In the DNHS subjects: B=4.86, P-value=3.71E-06, OR=2.78, 95%CI=1.84-4.19. |
|
Trend |
|
rs4701170
|
PTSD |
PRPF31 |
In the DNHS subjects: B=4.63, P-value=7.92E-06, OR=2.41, 95%CI=1.66-3.51. |
SNP rs4701170 maps in an intergenic region, and is located 1......
SNP rs4701170 maps in an intergenic region, and is located 14-Kb from the gene RP11-798K23.1, a putative lincRNA.
More...
|
Trend |
|
rs10502692
|
PTSD |
Intergenic |
In the DNHS subjects: B=-4.53, P-value=4.46E-06, OR=0.35, 95%CI=0.22-0.55. |
|
Trend |
|
rs1611133
|
PTSD |
HLA-G3 |
In the DNHS subjects: B=4.47, P-value=1.18E-06, OR=3.56, 95%CI=2.04-6.22. |
The next strongest signals were at SNP rs1611133.
The next strongest signals were at SNP rs1611133.
|
Trend |
|
rs11767398
|
PTSD |
LSMEM1 |
In the DNHS subjects: B=4.59, P-value=5.95E-06, OR=2.54, 95%CI=1.71-3.78. |
|
Trend |
