SNP Report

Basic Info

Name	rs4339660 dbSNP Ensembl
Location	8:130790976 - 130790976(+)
Variant Seq	A
Ancestral Allele	G
Ref Seq	G
Minor Allele Frequence	0.468051
Annotation	intron_variant
Variant Effect	intron_variant(ENST00000286355, ENST00000377928)
SIFT Annotation	tolerated
SIFT Variant Effect	tolerated(ENST00000286355, ENST00000377928)
PolyPhen Annotation	benign; possibly_damaging
PolyPhen Variant Effect	benign(ENST00000286355); possibly_damaging(ENST00000377928)
rSNP?	Yes Link in rVarBase
Related Regulatory Elements	n/a
Chromatin State	Weak transcription
No. of Marker's Association Results	1 (Positive: 0; Negative: 1; Trend: 0)
Source	Literature

SNP related association results

Normal genetic study related association results (count: 1)

Reference	Phenotype	Statistical Values	Author Comments	Marker's Category
Wolf, E. J.,2014	Dissociative symptom severity	P-value<0.05 P-value<0.05	Follow-up evaluation of ADCY8 revealed four other SNPs (rs43...... Follow-up evaluation of ADCY8 revealed four other SNPs (rs4339660, rs7015079, rs263238, and rs263234) that were nominally associated with dissociation severity (smallest P-value= .01). More...	Non-significant

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Association Results (Positive/Negative/Trend)
ADCY8	adenylate cyclase 8 (brain)	8q24	1(0/0/1)

SNPs in LD with rs4339660 (count: 80)

The LD data used here is based on 1000 Genome Phase I. LD SNP pairs were selected with a threshold r²<=0.8.

Literature-origin SNPs (count: 0)

LD-proxies (count: 80)

rs_ID	Literature-origin SNPs with LD	Annotation	r²[population]
rs3793387	rs4339660	intron_variant	1.0000[EUR]
rs2889477	rs4339660	intron_variant	1.0000[EUR]
rs1605903	rs4339660	downstream_gene_variant	0.9122[EUR]
rs7015398	rs4339660	downstream_gene_variant	1.0000[EUR]
rs7002481	rs4339660	downstream_gene_variant	1.0000[EUR]
rs11787207	rs4339660	downstream_gene_variant	0.9785[EUR]
rs2377075	rs4339660	downstream_gene_variant	1.0000[EUR]
rs1848776	rs4339660	downstream_gene_variant	0.9785[EUR]
rs9297815	rs4339660	intron_variant	0.9732[EUR]
rs7010990	rs4339660	downstream_gene_variant	0.9732[EUR]
rs6470852	rs4339660	downstream_gene_variant	1.0000[EUR]
rs13250130	rs4339660	downstream_gene_variant	0.9467[EUR]
rs13259683	rs4339660	downstream_gene_variant	0.9467[EUR]
rs11779279	rs4339660	downstream_gene_variant	0.9892[EUR]
rs10435556	rs4339660	downstream_gene_variant	0.9838[EUR]
rs1509858	rs4339660	intron_variant	0.9946[EUR]
rs1509854	rs4339660	downstream_gene_variant	1.0000[EUR]
rs1848778	rs4339660	downstream_gene_variant	0.8692[EUR]
rs10808585	rs4339660	downstream_gene_variant	1.0000[EUR]
rs4319115	rs4339660	downstream_gene_variant	0.9838[EUR]
rs13273744	rs4339660	downstream_gene_variant	0.9892[EUR]
rs1509860	rs4339660	intron_variant	0.9946[EUR]
rs12550841	rs4339660	downstream_gene_variant	0.9467[EUR]
rs10956546	rs4339660	downstream_gene_variant	0.9785[EUR]
rs1509859	rs4339660	intron_variant	0.9946[EUR]
rs11787356	rs4339660	downstream_gene_variant	0.9785[EUR]
rs11787187	rs4339660	downstream_gene_variant	0.9785[EUR]
rs11984653	rs4339660	downstream_gene_variant	0.9467[EUR]
rs11993878	rs4339660	downstream_gene_variant	1.0000[EUR]
rs34466289	rs4339660	downstream_gene_variant	1.0000[EUR]
rs1848777	rs4339660	downstream_gene_variant	0.9892[EUR]
rs1509855	rs4339660	downstream_gene_variant	1.0000[EUR]
rs1836628	rs4339660	downstream_gene_variant	0.9838[EUR]
rs17225213	rs4339660	downstream_gene_variant	0.9362[EUR]
rs1509856	rs4339660	downstream_gene_variant	0.9946[EUR]
rs10956550	rs4339660	downstream_gene_variant	1.0000[EUR]
rs9649965	rs4339660	intron_variant	0.9785[EUR]
rs13258564	rs4339660	downstream_gene_variant	0.9467[EUR]
rs7011898	rs4339660	downstream_gene_variant	0.9628[EUR]
rs4322021	rs4339660	downstream_gene_variant	0.9893[EUR]
rs2572867	rs4339660	intron_variant	0.8063[EUR]
rs10956549	rs4339660	downstream_gene_variant	1.0000[EUR]
rs873667	rs4339660	intron_variant	1.0000[EUR]
rs10435557	rs4339660	downstream_gene_variant	1.0000[EUR]
rs12676013	rs4339660	downstream_gene_variant	0.9892[EUR]
rs263249	rs4339660	intron_variant	0.8063[EUR]
rs6994426	rs4339660	downstream_gene_variant	0.9785[EUR]
rs13278937	rs4339660	intron_variant	0.9946[EUR]
rs6997501	rs4339660	downstream_gene_variant	1.0000[EUR]
rs2164304	rs4339660	intron_variant	1.0000[EUR]
rs10956548	rs4339660	downstream_gene_variant	0.9892[EUR]
rs10956551	rs4339660	intron_variant	0.9946[EUR]
rs17316525	rs4339660	downstream_gene_variant	0.9467[EUR]
rs10956553	rs4339660	intron_variant	0.9785[EUR]
rs1509857	rs4339660	intron_variant	0.9946[EUR]
rs10505564	rs4339660	downstream_gene_variant	1.0000[EUR]
rs1509853	rs4339660	downstream_gene_variant	1.0000[EUR]
rs17226139	rs4339660	intron_variant	0.9732[EUR]
rs12546136	rs4339660	intron_variant	0.9946[EUR]
rs10097218	rs4339660	downstream_gene_variant	0.9466[EUR]
rs7814990	rs4339660	downstream_gene_variant	1.0000[EUR]
rs7014884	rs4339660	downstream_gene_variant	1.0000[EUR]
rs12550840	rs4339660	downstream_gene_variant	0.9414[EUR]
rs10956552	rs4339660	intron_variant	0.9785[EUR]
rs13250177	rs4339660	downstream_gene_variant	1.0000[EUR]
rs12545452	rs4339660	downstream_gene_variant	0.9467[EUR]
rs2196315	rs4339660	intron_variant	1.0000[EUR]
rs873666	rs4339660	intron_variant	1.0000[EUR]
rs7011783	rs4339660	downstream_gene_variant	0.9626[EUR]
rs11777544	rs4339660	intron_variant	0.9626[EUR]
rs1594997	rs4339660	downstream_gene_variant	0.9838[EUR]
rs6998308	rs4339660	downstream_gene_variant	1.0000[EUR]
rs10956547	rs4339660	downstream_gene_variant	0.9892[EUR]
rs5000695	rs4339660	intron_variant	0.9946[EUR]
rs7831104	rs4339660	downstream_gene_variant	1.0000[EUR]
rs7007094	rs4339660	downstream_gene_variant	0.9785[EUR]
rs13273733	rs4339660	downstream_gene_variant	0.9892[EUR]
rs263247	rs4339660	downstream_gene_variant	0.8063[EUR]
rs1836627	rs4339660	downstream_gene_variant	0.9785[EUR]
rs12545966	rs4339660	downstream_gene_variant	0.9467[EUR]

SNP related eQTL (count: 1)

Gene Symbol	Gene Existed in PTSDgene?	Tissue	Trans/Cis	Source
RP11-259G18.3	No	Adipose Subcutaneous	cis	GTEx