Gene Report

Basic Info

Approved Symbol	ADCY8
Previous Symbol	ADCY3
Symbol Alias	"HBAC1\|AC8"
Approved Name	adenylate cyclase 8 (brain)
Location	8q24
Position	chr8:130780301-131042426, -1
External Links	HGNC: 239 Entrez Gene: 114 Ensembl: ENSG00000155897 UCSC: uc003ytd.4
No. of Association Results	1 (Positive: 0; Negative: 0; trend: 1)
Annotation Type	Literature-origin, Mapped by Literature SNP, Mapped by LD-proxy

Gene related association results

Normal genetic study related association results (count: 1)

Reference	Phenotype	Marker	Gene's Category
Wolf, E. J.,2014	Dissociative symptom severity	rs263232 ; rs263234 ; rs263238 ; rs4339660 ; rs7015079	Trend

Gene functional annotation

Gene related GO terms (count: 28)

ID	Name	Type	Evidence[PMID]	No. of Genes in PTSDgene
GO:0007202	activation of phospholipase C activity	biological process	TAS	4
GO:0007165	signal transduction	biological process	TAS	34
GO:0005886	plasma membrane	cellular component	TAS	99
GO:0048011	neurotrophin TRK receptor signaling pathway	biological process	TAS	11
GO:0007189	adenylate cyclase-activating G-protein coupled receptor signaling pathway	biological process	IBA; TAS	2
GO:0046872	metal ion binding	molecular function	IEA	20
GO:0045087	innate immune response	biological process	TAS	15
GO:0016021	integral component of membrane	cellular component	IEA	56
GO:0007268	synaptic transmission	biological process	TAS	32
GO:0004016	adenylate cyclase activity	molecular function	TAS[8076676]	1
GO:0007616	long-term memory	biological process	IEA	3
GO:0006833	water transport	biological process	TAS	1
GO:0044281	small molecule metabolic process	biological process	TAS	38
GO:0007193	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway	biological process	IBA; TAS	2
GO:0003091	renal water homeostasis	biological process	TAS	1
GO:0071377	cellular response to glucagon stimulus	biological process	TAS	1
GO:0016020	membrane	cellular component	TAS[8163524]	42
GO:0008543	fibroblast growth factor receptor signaling pathway	biological process	TAS	9
GO:0019933	cAMP-mediated signaling	biological process	IBA	4
GO:0007611	learning or memory	biological process	TAS[8076676]	6
GO:0007173	epidermal growth factor receptor signaling pathway	biological process	TAS	11
GO:0008294	calcium- and calmodulin-responsive adenylate cyclase activity	molecular function	TAS[8163524]	1
GO:0006112	energy reserve metabolic process	biological process	TAS	3
GO:0005524	ATP binding	molecular function	IEA	23
GO:0034199	activation of protein kinase A activity	biological process	TAS	1
GO:0055085	transmembrane transport	biological process	TAS	14
GO:0006171	cAMP biosynthetic process	biological process	IEA	1
GO:0005622	intracellular	cellular component	IBA; IEA	15

Gene related KEGG pathways (count: 7)

ID	Name	No. of Genes in PTSDgene
hsa04720	Long-term potentiation	6
hsa00230	Purine metabolism	2
hsa04912	GnRH signaling pathway	4
hsa04916	Melanogenesis	2
hsa04020	Calcium signaling pathway	11
hsa04742	Taste transduction	1
hsa04540	Gap junction	6

Gene related interactors from protein-protein interactions data in PINA v2 (count: 2)

Gene	Interactor	Interactor in PTSDgene?	Experiment Method	Interaction Type	PMID
ADCY8	PPP2CA	No	--	--	16258073
ADCY8	CALM1	No	--	--	10075700 , 10075700 , 16258073