SNP Report
Basic Info
| Name | rs10055255 dbSNP Ensembl | ||
|---|---|---|---|
| Location | 5:76968168 - 76968168(+) | ||
| Variant Seq | T | ||
| Ancestral Allele | T | ||
| Ref Seq | A | ||
| Minor Allele Frequence | 0.466653 | ||
| Annotation | intron_variant; non_coding_transcript_variant | ||
| Variant Effect | intron_variant(ENST00000274368, ENST00000503763, ENST00000514258); non_coding_transcript_variant(ENST00000503763, ENST00000514258) | ||
| SIFT Annotation | deleterious; tolerated | ||
| SIFT Variant Effect | deleterious(ENST00000274368); tolerated(ENST00000506501) | ||
| PolyPhen Annotation | probably_damaging | ||
| PolyPhen Variant Effect | probably_damaging(ENST00000506501, ENST00000274368) | ||
| rSNP? | Yes Link in rVarBase | ||
| Related Regulatory Elements | n/a | ||
| Chromatin State | Weak transcription;Strong transcription | ||
| No. of Marker's Association Results | 1 (Positive: 1; Negative: 0; Trend: 0) | ||
| Source | Literature | ||
SNP related association results
| Reference | Phenotype | Statistical Values | Author Comments | Marker's Category |
|---|---|---|---|---|
| Davydow, D. S.,2014 | Post-ICU PTSD | In unadjusted analyses, being homozygous for the CRHBP (rs10...... In unadjusted analyses, being homozygous for the CRHBP (rs10055255) T allele with post-ICU PTSD: beta=?10.8, 95%CI=?17.7, ?3.9; P-value= 0.002. More... | In unadjusted analyses, being homozygous for the CRHBP (rs10...... In unadjusted analyses, being homozygous for the CRHBP (rs10055255) T allele was associated with significantly fewer post-ICU PTSD. The unadjusted associations we found remained significant in our fully adjusted regression models that controlled for age, race, SAPS II score at ICU admission, and in-ICU corticosteroid exposure. After Bonferroni correction, the association of homozygosity for the CRHBP (rs10055255) T allele with fewer post-ICU PTSD symptoms continued to meet the threshold for statistical significance. More... | Significant |
SNP related genes (count: 1)
| Approved Symbol | Approved Name | Location | No. of Association Results (Positive/Negative/Trend)  |
|---|---|---|---|
| CRHBP | corticotropin releasing hormone binding protein | 5q13.3 | 1(1/0/0) |
SNPs in LD with rs10055255 (count: 8)
Literature-origin SNPs (count: 0)
LD-proxies (count: 8)
SNP related eQTL (count: 1)