PTSDgene database

SNP Report

Basic Info
Name rs10055255 dbSNP Ensembl
Location 5:76968168 - 76968168(+)
Variant Seq T
Ancestral Allele T
Ref Seq A
Minor Allele Frequence 0.466653
Annotation intron_variant; non_coding_transcript_variant
Variant Effect intron_variant(ENST00000274368, ENST00000503763, ENST00000514258); non_coding_transcript_variant(ENST00000503763, ENST00000514258)
SIFT Annotation deleterious; tolerated
SIFT Variant Effect deleterious(ENST00000274368); tolerated(ENST00000506501)
PolyPhen Annotation probably_damaging
PolyPhen Variant Effect probably_damaging(ENST00000506501, ENST00000274368)
rSNP? Yes Link in rVarBase
Related Regulatory Elements n/a
Chromatin State Weak transcription;Strong transcription
No. of Marker's Association Results 1 (Positive: 1; Negative: 0; Trend: 0)
Source Literature

SNP related association results
Normal genetic study related association results (count: 1)
Reference Phenotype Statistical Values Author Comments Marker's Category
Davydow, D. S.,2014 Post-ICU PTSD In unadjusted analyses, being homozygous for the CRHBP (rs10...... In unadjusted analyses, being homozygous for the CRHBP (rs10055255) T allele with post-ICU PTSD: beta=?10.8, 95%CI=?17.7, ?3.9; P-value= 0.002. More... In unadjusted analyses, being homozygous for the CRHBP (rs10...... In unadjusted analyses, being homozygous for the CRHBP (rs10055255) T allele was associated with significantly fewer post-ICU PTSD. The unadjusted associations we found remained significant in our fully adjusted regression models that controlled for age, race, SAPS II score at ICU admission, and in-ICU corticosteroid exposure. After Bonferroni correction, the association of homozygosity for the CRHBP (rs10055255) T allele with fewer post-ICU PTSD symptoms continued to meet the threshold for statistical significance. More... Significant


SNP related genes (count: 1)
Approved Symbol Approved Name Location No. of Association Results (Positive/Negative/Trend)
CRHBP corticotropin releasing hormone binding protein 5q13.3 1(1/0/0)

SNPs in LD with rs10055255 (count: 8)
The LD data used here is based on 1000 Genome Phase I. LD SNP pairs were selected with a threshold r2<=0.8.

Literature-origin SNPs (count: 0)

LD-proxies (count: 8)


SNP related eQTL (count: 1)
Gene Symbol Gene Existed in PTSDgene? Tissue Trans/Cis Source
CRHR1-IT1 Yes Adipose Subcutaneous cis GTEx