Gene Report

Basic Info

Approved Symbol	CRHBP
Symbol Alias	"CRF-BP\|CRFBP"
Approved Name	corticotropin releasing hormone binding protein
Previous Name	corticotropin releasing hormone-binding protein
Location	5q13.3
Position	chr5:76952713-76981158, 1
External Links	HGNC: 2356 Entrez Gene: 1393 Ensembl: ENSG00000145708 UCSC: uc003ker.3
No. of Association Results	1 (Positive: 1; Negative: 0; trend: 0)
Annotation Type	Literature-origin, Mapped by Literature SNP, Mapped by LD-proxy

Gene related association results

Normal genetic study related association results (count: 1)

Reference	Phenotype	Marker	Gene's Category
Davydow, D. S.,2014	Post-ICU PTSD	rs10055255	Significant

Gene functional annotation

Gene related GO terms (count: 41)

ID	Name	Type	Evidence[PMID]	No. of Genes in PTSDgene
GO:0042277	peptide binding	molecular function	ISS	3
GO:0005615	extracellular space	cellular component	IDA[1846945\|18559919]	27
GO:0035690	cellular response to drug	biological process	ISS	6
GO:0045055	regulated exocytosis	biological process	IDA[21624661]	1
GO:0071320	cellular response to cAMP	biological process	ISS	2
GO:0043679	axon terminus	cellular component	ISS	6
GO:0005874	microtubule	cellular component	ISS	8
GO:0009755	hormone-mediated signaling pathway	biological process	IDA[18234674]	2
GO:0030425	dendrite	cellular component	ISS	19
GO:0007565	female pregnancy	biological process	IDA[18559919]; IEP[1846945]	9
GO:0048149	behavioral response to ethanol	biological process	IMP[21039637]	4
GO:0005515	protein binding	molecular function	IPI[18234674]	169
GO:0006954	inflammatory response	biological process	IDA[18559919]	10
GO:0005794	Golgi apparatus	cellular component	IDA[21624661]	17
GO:0035865	cellular response to potassium ion	biological process	IDA[21624661]	2
GO:0071314	cellular response to cocaine	biological process	ISS	1
GO:0051424	corticotropin-releasing hormone binding	molecular function	IDA[1846945]; IPI[18234674]	1
GO:0031045	dense core granule	cellular component	ISS	2
GO:0043204	perikaryon	cellular component	ISS	6
GO:0051460	negative regulation of corticotropin secretion	biological process	IDA[1846945]	1
GO:0051459	regulation of corticotropin secretion	biological process	IDA[13150566]	1
GO:0071391	cellular response to estrogen stimulus	biological process	IDA[15345745]	1
GO:0005771	multivesicular body	cellular component	ISS	1
GO:0071356	cellular response to tumor necrosis factor	biological process	IDA[15345745]	3
GO:0007165	signal transduction	biological process	TAS[7477348]	34
GO:0002125	maternal aggressive behavior	biological process	IEA	1
GO:0005783	endoplasmic reticulum	cellular component	IDA[21624661]	20
GO:0005767	secondary lysosome	cellular component	ISS	1
GO:0071277	cellular response to calcium ion	biological process	ISS	1
GO:0097211	cellular response to gonadotropin-releasing hormone	biological process	ISS	1
GO:2000310	regulation of N-methyl-D-aspartate selective glutamate receptor activity	biological process	ISS	3
GO:0043196	varicosity	cellular component	ISS	2
GO:1900011	negative regulation of corticotropin-releasing hormone receptor activity	biological process	IDA[18234674]	1
GO:0033554	cellular response to stress	biological process	IMP[21039637]	1
GO:0071392	cellular response to estradiol stimulus	biological process	IDA[15345745]	1
GO:0030141	secretory granule	cellular component	IDA[21624661]	4
GO:0042445	hormone metabolic process	biological process	IEA	2
GO:0005634	nucleus	cellular component	ISS	81
GO:0001963	synaptic transmission, dopaminergic	biological process	ISS	5
GO:0007611	learning or memory	biological process	TAS[7477348]	6
GO:0005622	intracellular	cellular component	ISS	15

Gene related KEGG pathways (count: 0)

Gene related interactors from protein-protein interactions data in PINA v2 (count: 1)

Gene	Interactor	Interactor in PTSDgene?	Experiment Method	Interaction Type	PMID
CRHBP	UCN	No	--	--	8612563 , 8612563