Gene Report

Basic Info

Approved Symbol	POLB
Approved Name	polymerase (DNA directed), beta
Location	8p12-p11
Position	chr8:42338454-42371808, 1
External Links	HGNC: 9174 Entrez Gene: 5423 Ensembl: ENSG00000070501 UCSC: uc003xoz.2
No. of Association Results	0. Gene is from "rSNP target"
Annotation Type	rSNP target

Gene functional annotation

Gene related GO terms (count: 34)

ID	Name	Type	Evidence[PMID]	No. of Genes in PTSDgene
GO:0007568	aging	biological process	IEA	11
GO:0006974	cellular response to DNA damage stimulus	biological process	IMP[21362556]	5
GO:0006287	base-excision repair, gap-filling	biological process	IEA	1
GO:0007435	salivary gland morphogenesis	biological process	IEA	1
GO:0019899	enzyme binding	molecular function	IPI[16600869\|19713937\|21362556]	13
GO:0071707	immunoglobulin heavy chain V-D-J recombination	biological process	IEA	1
GO:0055093	response to hyperoxia	biological process	IEA	2
GO:0003887	DNA-directed DNA polymerase activity	molecular function	IDA[9207062\|16600869]	1
GO:0048536	spleen development	biological process	IEA	2
GO:0010332	response to gamma radiation	biological process	IEA	3
GO:0008017	microtubule binding	molecular function	IDA[15725623]	6
GO:0016446	somatic hypermutation of immunoglobulin genes	biological process	IEA	1
GO:0051402	neuron apoptotic process	biological process	IEA	2
GO:0005515	protein binding	molecular function	IPI[9207062\|15520167\|25416956]	169
GO:0006954	inflammatory response	biological process	IEA	10
GO:0005654	nucleoplasm	cellular component	TAS	43
GO:0043234	protein complex	cellular component	IDA[25378300]	10
GO:0006261	DNA-dependent DNA replication	biological process	TAS[8168825]	1
GO:0005634	nucleus	cellular component	IDA[19713937\|21362556]	81
GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	biological process	IEA	2
GO:0046872	metal ion binding	molecular function	IEA	20
GO:0048872	homeostasis of number of cells	biological process	IEA	1
GO:0016829	lyase activity	molecular function	IDA[16600869]	1
GO:0005876	spindle microtubule	cellular component	IDA[15725623]	3
GO:0006290	pyrimidine dimer repair	biological process	IEA	1
GO:0003684	damaged DNA binding	molecular function	IEA	3
GO:0005737	cytoplasm	cellular component	IDA[15725623\|19713937\|21362556]	109
GO:0006297	nucleotide-excision repair, DNA gap filling	biological process	IMP[20227374]	1
GO:0006281	DNA repair	biological process	TAS	8
GO:0006284	base-excision repair	biological process	IDA[16600869]; IMP[21362556]; TAS	2
GO:0048535	lymph node development	biological process	IEA	3
GO:0005874	microtubule	cellular component	IDA[15725623]	8
GO:0045471	response to ethanol	biological process	IEA	18
GO:0071897	DNA biosynthetic process	biological process	IEA	1

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in PTSDgene
hsa03410	Base excision repair	1

Gene related interactors from protein-protein interactions data in PINA v2 (count: 16)

Gene	Interactor	Interactor in PTSDgene?	Experiment Method	Interaction Type	PMID
POLB	TAF1D	No	--	colocalization	15520167 , 15520167 , 15520167 , 15520167 , 15520167 , 15520167 , 15520167
POLB	XRCC1	No	--	--	15107487 , 15367657 , 15520167 , 11467963 , 8978692 , 11467963 , 8978692 , 8978692 , 15520167
POLB	SRPK2	No	--	--	23602568 , 23602568
POLB	WRN	No	--	--	17173071
POLB	STUB1	No	--	--	19713937
POLB	UBC	No	--	--	21139048 , 19713937 , 19713937
POLB	PNKP	No	--	--	11163244 , 11163244 , 11163244
POLB	PARP1	No	--	--	20303835 , 20303835 , 20302655
POLB	UNG	No	biochemical	association, colocalization	10629618 , 10629618
POLB	PRKCA	Yes	--	--	2040602
POLB	TLE1	No	--	--	16169070 , 16169070 , 16169070 , 16169070 , 16169070
POLB	HUWE1	No	--	--	19713937
POLB	NEIL1	No	--	--	15260972
POLB	APEX1	No	--	--	9207062
POLB	NCAPG	No	--	--	16543152
POLB	PCNA	No	--	--	12063248 , 14988403