Gene Report

Basic Info

Approved Symbol	MAPT
Previous Symbol	"DDPAC\|MAPTL"
Symbol Alias	"MTBT1\|tau\|PPND\|FTDP-17\|TAU\|MSTD\|MTBT2\|FLJ31424\|MGC138549\|PPP1R103"
Approved Name	microtubule associated protein tau
Name Alias	"G protein beta1/gamma2 subunit-interacting factor 1\|microtubule-associated protein tau, isoform 4\|protein phosphatase 1, regulatory subunit 103"
Location	17q21
Position	chr17:45894382-46028334, 1
External Links	HGNC: 6893 Entrez Gene: 4137 Ensembl: ENSG00000186868 UCSC: uc010dau.3
No. of Association Results	0. Gene is from "Mapped by LD-proxy, rSNP target"
Annotation Type	Mapped by LD-proxy, rSNP target

Gene functional annotation

Gene related GO terms (count: 45)

ID	Name	Type	Evidence[PMID]	No. of Genes in PTSDgene
GO:0005930	axoneme	cellular component	IEA	1
GO:0019901	protein kinase binding	molecular function	IEA	4
GO:0032387	negative regulation of intracellular transport	biological process	IEA	1
GO:0000226	microtubule cytoskeleton organization	biological process	IDA[1057175]	2
GO:0047497	mitochondrion transport along microtubule	biological process	IEA	1
GO:0005515	protein binding	molecular function	IPI[3111527\|7566652\|9689133\|10987820\|15953362\|16275660\|16446437\|17078951\|17317006\|17932487\|19138662\|19527721\|19647741\|21985244\|22303461\|23001711\|23399914\|23589030\|23666762\|24028865\|24113872\|24165324\|24581495]	169
GO:0007584	response to nutrient	biological process	IEA	5
GO:0031175	neuron projection development	biological process	IBA	8
GO:0031113	regulation of microtubule polymerization	biological process	NAS[1057175]	1
GO:0048699	generation of neurons	biological process	NAS[8522593]	1
GO:0005200	structural constituent of cytoskeleton	molecular function	TAS[2498079]	4
GO:0045298	tubulin complex	cellular component	IDA[8642405]	1
GO:0044297	cell body	cellular component	IDA[25620700]	5
GO:0097418	neurofibrillary tangle	cellular component	NAS[25620700]	1
GO:0005829	cytosol	cellular component	TAS	78
GO:0060632	regulation of microtubule-based movement	biological process	IEA	1
GO:0051721	protein phosphatase 2A binding	molecular function	IEA	3
GO:0005875	microtubule associated complex	cellular component	TAS[10747907]	1
GO:0006921	cellular component disassembly involved in execution phase of apoptosis	biological process	TAS	1
GO:0005886	plasma membrane	cellular component	IDA[8522593]	99
GO:0030424	axon	cellular component	IDA[8642405]	16
GO:0014069	postsynaptic density	cellular component	IEA	11
GO:0030426	growth cone	cellular component	IDA[8642405]	4
GO:0048675	axon extension	biological process	IEA	3
GO:0008631	intrinsic apoptotic signaling pathway in response to oxidative stress	biological process	IEA	1
GO:0012501	programmed cell death	biological process	TAS	4
GO:0006915	apoptotic process	biological process	TAS	19
GO:0001764	neuron migration	biological process	IEA	3
GO:0005874	microtubule	cellular component	IEA	8
GO:0010506	regulation of autophagy	biological process	IGI[19074461]	2
GO:0010033	response to organic substance	biological process	IEA	2
GO:0071813	lipoprotein particle binding	molecular function	IPI[7972031]	2
GO:0007420	brain development	biological process	IEA	4
GO:0008088	axo-dendritic transport	biological process	IEA	1
GO:0007565	female pregnancy	biological process	IEA	9
GO:0007628	adult walking behavior	biological process	IEA	3
GO:0034399	nuclear periphery	cellular component	IDA[19157893]	1
GO:0017124	SH3 domain binding	molecular function	IPI[9763511]	5
GO:0008017	microtubule binding	molecular function	IDA[1918161]	6
GO:0031116	positive regulation of microtubule polymerization	biological process	IDA[1421571\|7706316]	3
GO:0019899	enzyme binding	molecular function	IPI[9736630\|12888622\|20133804]	13
GO:0045773	positive regulation of axon extension	biological process	IDA[1389180]	1
GO:0036464	cytoplasmic ribonucleoprotein granule	cellular component	IDA[15121898]	1
GO:0030425	dendrite	cellular component	IDA[25620700]	19
GO:0034185	apolipoprotein binding	molecular function	IPI[7566652]	1

Gene related KEGG pathways (count: 3)

ID	Name	No. of Genes in PTSDgene
hsa04010	MAPK signaling pathway	13
hsa05010	Alzheimer's disease	4
hsa01510	Neurodegenerative Diseases	2

Gene related interactors from protein-protein interactions data in PINA v2 (count: 71)

Gene	Interactor	Interactor in PTSDgene?	Experiment Method	Interaction Type	PMID
MAPT	BAG1	No	--	--	17954934 , 17954934 , 17954934
MAPT	MARK2	No	--	--	23001711 , 23001711
MAPT	RPS6KB1	No	--	--	17512525 , 17512525 , 16364302 , 16364302 , 17512525 , 16364302 , 17512525 , 16364302 , 16364302 , 17512525 , 16364302 , 16364302
MAPT	CSNK2A1	No	--	--	15882073
MAPT	UBE2D2	No	--	--	14612456 , 14612456
MAPT	ACTB	No	--	--	6304075
MAPT	RPS27A	No	--	--	18292230 , 18292230 , 18292230
MAPT	SLC1A2	No	--	association	19527721 , 19527721 , 19527721 , 19527721 , 19527721 , 19527721 , 19527721 , 19527721 , 19527721 , 19527721 , 19527721 , 19527721
MAPT	PKN1	No	--	--	11104762 , 9546672
MAPT	TUBA1A	No	--	--	22565157
MAPT	MAPK11	No	--	--	9199504
MAPT	PPP5C	No	--	--	12435421 , 12435421
MAPT	YWHAB	No	--	--	10840038 , 12176984 , 10840038
MAPT	AATF	No	--	--	14697667 , 14697667 , 14697667 , 14697667 , 14697667 , 14697667 , 14697667 , 14697667
MAPT	MAPK8	No	--	--	9199504
MAPT	CAMK2A	No	--	--	17512525 , 9771888
MAPT	SIRT1	No	--	--	20869593 , 20869593
MAPT	CSNK1A1	No	--	--	9771888
MAPT	PPP2R4	No	--	--	12435421
MAPT	GSK3A	No	--	--	16446437 , 16446437 , 16446437 , 9735171 , 7931292 , 7931292
MAPT	PTK2B	Yes	--	--	17512525
MAPT	MAPK12	No	--	--	9832145
MAPT	CASP8	No	--	--	12888622
MAPT	GSK3B	No	--	--	24165324 , 24165324 , 21985244 , 22965877 , 10090741 , 22965877 , 21985244 , 9771888 , 12387894 , 17078951 , 17078951 , 17078951 , 21985244 , 17512525 , 21985244 , 21985244 , 9546672 , 17078951 , 21985244 , 17512525 , 24165324 , 21985244 , 14612456 , 17078951 , 24165324 , 17078951 , 17512525 , 17512525 , 17512525 , 17078951 , 9832145 , 17078951
MAPT	PRKCD	No	--	--	9771888
MAPT	PASK	No	--	--	21418524 , 21418524 , 21418524 , 21418524
MAPT	YWHAZ	No	coimmunoprecipitation	association	19647741 , 19647741 , 19647741 , 19647741 , 19647741 , 19647741 , 19647741 , 19647741 , 19647741 , 19647741 , 19647741 , 19647741 , 17317006 , 19138662 , 19138662 , 19647741 , 19647741 , 19647741 , 19647741 , 19647741 , 19647741 , 19138662 , 19647741 , 19647741 , 17317006 , 17317006 , 10840038 , 19647741 , 19647741 , 19647741 , 19647741 , 19647741 , 10840038 , 19647741 , 19647741 , 19647741 , 10840038 , 17317006 , 17317006 , 19647741 , 19647741 , 19647741 , 19647741 , 19647741 , 19647741 , 19647741
MAPT	SQSTM1	No	--	--	15953362 , 15953362
MAPT	CASP3	No	--	--	12888622
MAPT	HSPA4	No	--	--	23271055 , 23271055 , 23271055 , 14962978 , 21985244
MAPT	NRF1	No	--	colocalization	24250222
MAPT	ARHGEF40	No	--	--	16143467
MAPT	PIN1	No	--	--	16365047 , 10391244 , 10391244
MAPT	Mapk12	No	--	--	9199504 , 9199504
MAPT	TAS2R43	No	--	--	16176937 , 16176937
MAPT	SYK	No	--	--	18070606 , 18070606
MAPT	CSNK1D	No	--	--	16618118
MAPT	STXBP1	No	--	--	12963086 , 12963086
MAPT	AKT1	No	--	--	18292230 , 18292230 , 17512525 , 17512525 , 17512525 , 17512525 , 18292230
MAPT	CDK5	No	--	--	10762698 , 12387894 , 17078951 , 9565682 , 9832145 , 17078951 , 17078951 , 9771888 , 9735171 , 17078951
MAPT	SPTB	No	--	--	6743699
MAPT	RPS6KA1	No	--	--	17512525 , 17512525 , 17512525 , 17512525 , 17512525
MAPT	TUBA4A	No	--	--	9922135
MAPT	RPS6KA3	No	--	--	17512525 , 17512525 , 17512525 , 17512525 , 17512525 , 9546672
MAPT	PHKG1	No	--	--	10737616
MAPT	HSPA8	No	--	--	14612456 , 17954934 , 14612456 , 14612456
MAPT	UBA52	No	--	--	14612456 , 14612456
MAPT	HDAC6	No	--	--	18636984 , 18636984
MAPT	PSEN1	No	biochemical	colocalization	9689133 , 9689133
MAPT	PPP2R5A	No	--	--	12435421
MAPT	NUB1	No	--	--	22965877 , 22965877
MAPT	CASP1	No	--	--	12888622
MAPT	DCTN1	Yes	--	colocalization	17932487 , 17932487 , 17932487 , 17932487 , 17932487 , 17932487 , 17932487 , 17932487 , 17932487 , 17932487 , 17932487 , 17932487 , 17932487 , 17932487 , 17932487 , 17932487 , 17932487 , 17932487 , 17932487 , 17932487 , 17932487 , 17932487 , 17932487 , 17932487
MAPT	LIMS1	No	--	--	23554879 , 23554879
MAPT	PPP2CB	No	--	--	1330687
MAPT	PSMC2	No	--	--	15953362
MAPT	CAPN2	No	--	--	14993287
MAPT	CALM1	No	--	--	2123288 , 2123288
MAPT	TRAF6	No	--	--	15953362
MAPT	CASP6	No	--	--	12888622
MAPT	PRKACA	No	--	--	9546672 , 10090741 , 21127069 , 12435421 , 9771888
MAPT	SNCA	No	--	association, colocalization	21985244 , 21985244 , 15904919 , 21127069 , 21985244 , 21985244 , 10464279 , 10464279 , 10464279 , 17408955
MAPT	MARK1	No	--	--	10090741 , 8631898 , 9771888
MAPT	MARK4	No	--	--	14594945 , 14594945
MAPT	STUB1	No	--	association	18292230 , 20466727 , 16275660 , 20466727 , 15447663 , 23237806 , 14962978 , 14612456 , 14612456 , 15447663 , 14612456 , 17304350 , 23554879 , 15447663 , 16275660 , 16275660 , 18292230 , 18292230 , 16275660 , 14612456 , 18292230 , 18292230
MAPT	CASP7	No	--	--	12888622
MAPT	LRRK2	No	--	--	24113872 , 24113872 , 22303461 , 24113872 , 24113872 , 24113872 , 24113872 , 24113872 , 22303461 , 24113872 , 22303461 , 22303461 , 22303461 , 22303461 , 22303461 , 22303461 , 24113872
MAPT	EP300	No	--	--	20869593
MAPT	PPP2CA	No	--	--	1330687
MAPT	YWHAQ	No	coimmunoprecipitation	association	15650334 , 15650334 , 15650334
MAPT	SRC	No	--	--	10 , 10 , 10 , 10 , 16115884 , 16115884