PTSDgene database

Study Report

Study Information
Basic Info
Reference
Citation Pivac, N., et al. (2007). "Monoamine oxidase (MAO) intron 13 polymorphism and platelet MAO-B activity in combat-related posttraumatic stress disorder." J Affect Disord 103(1-3): 131-138.
Phenotype PTSD
Trauma Combat
Study Design Case-control
Study Type Candidate gene association study
Sample Size 106 cases, 41 trauma exposed controls, 242 healthy controls
SNP/Marker Size 1 Variant
Predominant Ethnicity Caucasian
Population Croatian
Gender All males
Age Cases: mean age=40.1 years, SD=7.3; trauma exposed controls: mean age=37.6 years, SD=4.2; healthy controls: mean age=41.8 years, SD=11.1

Detail Info

Genetic result reported by this study
Normal genetic result reported by this study (count: 1)
Marker Phenotype Related Gene Statistical Values Author Comments Marker's Category
MAO-B_intron 13 PTSD MAOB Genotype: Between healthy controls and veterans with nonpsychotic PTSD: X2= 1.335; df=1; P-value=0.248, OR=1.398, 95% CI=0.8380 to 2.333; P-value=0.2399. Between veterans with nonpsychotic and psychotic PTSD: X2= 0.0280; df=1; P-value=0.867. Between healthy controls and veterans who did not develop PTSD: X2= 0.0176; df=1; P-value=0.894. Between healthy controls and veterans with psychotic PTSD: X2= 0.0229; df=1; P-value=0.880. Between veterans with nonpsychotic PTSD and veterans without PTSD: X2= 0.497, df=1; P-value=0.481. Allele: Between healthy controls and veterans with nonpsychotic PTSD: OR=1.398, 95%CI= 0.8380 to 2.333; P-value=0.2399. Between veterans with nonpsychotic and psychotic PTSD: OR=0.8330; 95% CI= 0.3380 to 2.053, P-value=0.8188. Between healthy controls and veterans with psychotic PTSD: OR=1.165; 95% CI= 0.5105 to 2.657; P-value=0.8332. Between healthy controls and veterans without PTSD: OR=0.9874; 95% CI= 0.5067 to 1.924; P-value=1.0000. Allele frequencies of the MAO-B genotype were equally distri...... Allele frequencies of the MAO-B genotype were equally distributed. The OR statistics showed no significant differences in carrying the "A allele" or the "G allele". More... Non-significant