Study Report
Study Information
Basic Info
| Reference |
Pivac, N.,2007 PMID: 17289152
|
| Citation |
Pivac, N., et al. (2007). "Monoamine oxidase (MAO) intron 13 polymorphism and platelet MAO-B activity in combat-related posttraumatic stress disorder." J Affect Disord 103(1-3): 131-138. |
| Phenotype |
PTSD |
| Trauma |
Combat |
| Study Design |
Case-control |
| Study Type |
Candidate gene association study |
| Sample Size |
106 cases, 41 trauma exposed controls, 242 healthy controls |
| SNP/Marker Size |
1 Variant |
| Predominant Ethnicity |
Caucasian |
| Population |
Croatian |
| Gender |
All males |
| Age |
Cases: mean age=40.1 years, SD=7.3; trauma exposed controls: mean age=37.6 years, SD=4.2; healthy controls: mean age=41.8 years, SD=11.1 |
Detail Info
| Sample Diagnosis |
DSM-IV |
| Related Diagnostic Tools |
Structured Clinical Interview for DSM-IV (SCID), Positive and Negative Syndrome Scale (PANSS), Clinician Administered PTSD Scale (CAPS), The diagnosis of PTSD was made by a team of psychiatrists. |
| Sample Status |
Within 78 patients with PTSD without psychotic features, 10 patients were diagnosed with PTSD alone, 42 patients with comorbid depression, 11 with comorbid alcoholism, 9 with comorbid general anxiety disorder and 6 with comorbid panic attacks. |
| Controls Exposed |
VA |
| Replication Size |
None |
| Result Summary |
Two-way ANOVAs revealed a significant effect of diagnosis and smoking, a significant effect of smoking, no significant effect of genotype, and no significant interaction between genotype, smoking or diagnosis, on platelet MAO-B activity. The MAO-B intron 13 polymorphism was not functional, and did not affect platelet MAO-B activity. The allele frequencies of the MAO-B genotype were similarly distributed among healthy controls and veterans with or without PTSD and/or psychotic symptoms. |
| Potential Biomarker |
The results suggest that platelet MAO-B activity, controlled for smoking status, might be used as a peripheral marker of the psychotic symptoms in PTSD. |
Genetic result reported by this study
Normal genetic result reported by this study (count: 1)
| Marker |
Phenotype |
Related Gene |
Statistical Values |
Author Comments |
Marker's Category |
|
MAO-B_intron 13
|
PTSD |
MAOB |
Genotype: Between healthy controls and veterans with nonpsychotic PTSD: X2= 1.335; df=1; P-value=0.248, OR=1.398, 95% CI=0.8380 to 2.333; P-value=0.2399. Between veterans with nonpsychotic and psychotic PTSD: X2= 0.0280; df=1; P-value=0.867. Between healthy controls and veterans who did not develop PTSD: X2= 0.0176; df=1; P-value=0.894. Between healthy controls and veterans with psychotic PTSD: X2= 0.0229; df=1; P-value=0.880. Between veterans with nonpsychotic PTSD and veterans without PTSD: X2= 0.497, df=1; P-value=0.481. Allele: Between healthy controls and veterans with nonpsychotic PTSD: OR=1.398, 95%CI= 0.8380 to 2.333; P-value=0.2399. Between veterans with nonpsychotic and psychotic PTSD: OR=0.8330; 95% CI= 0.3380 to 2.053, P-value=0.8188. Between healthy controls and veterans with psychotic PTSD: OR=1.165; 95% CI= 0.5105 to 2.657; P-value=0.8332. Between healthy controls and veterans without PTSD: OR=0.9874; 95% CI= 0.5067 to 1.924; P-value=1.0000. |
Allele frequencies of the MAO-B genotype were equally distri......
Allele frequencies of the MAO-B genotype were equally distributed. The OR statistics showed no significant differences in carrying the "A allele" or the "G allele".
More...
|
Non-significant |
