Gene Report

Basic Info

Approved Symbol	LTA
Previous Symbol	TNFB
Symbol Alias	"TNFSF1\|LT"
Approved Name	lymphotoxin alpha
Previous Name	lymphotoxin alpha (TNF superfamily, member 1)
Name Alias	TNF superfamily member 1
Location	6p21.3
Position	chr6:31572054-31574324, 1
External Links	HGNC: 6709 Entrez Gene: 4049 Ensembl: ENSG00000226979 UCSC: uc011dnu.2
No. of Association Results	0. Gene is from "Mapped by Literature SNP"
Annotation Type	Mapped by Literature SNP

Gene functional annotation

Gene related GO terms (count: 23)

ID	Name	Type	Evidence[PMID]	No. of Genes in PTSDgene
GO:0042493	response to drug	biological process	IEA	25
GO:0005164	tumor necrosis factor receptor binding	molecular function	IEA	5
GO:0005125	cytokine activity	molecular function	IEA	7
GO:0007267	cell-cell signaling	biological process	TAS[6334807]	10
GO:0005615	extracellular space	cellular component	IEA	27
GO:0005886	plasma membrane	cellular component	TAS	99
GO:0032729	positive regulation of interferon-gamma production	biological process	IEA	3
GO:0006915	apoptotic process	biological process	TAS[6334807]	19
GO:0006959	humoral immune response	biological process	IEA	3
GO:0005102	receptor binding	molecular function	TAS[3001529]	13
GO:0048535	lymph node development	biological process	IEA	3
GO:0050830	defense response to Gram-positive bacterium	biological process	IEA	6
GO:0044130	negative regulation of growth of symbiont in host	biological process	IEA	3
GO:0032496	response to lipopolysaccharide	biological process	IEA	9
GO:0033209	tumor necrosis factor-mediated signaling pathway	biological process	TAS	6
GO:0043065	positive regulation of apoptotic process	biological process	IEA	12
GO:0002925	positive regulation of humoral immune response mediated by circulating immunoglobulin	biological process	IEA	2
GO:0060252	positive regulation of glial cell proliferation	biological process	IEA	1
GO:0007584	response to nutrient	biological process	IEA	5
GO:0001666	response to hypoxia	biological process	IEA	13
GO:0007165	signal transduction	biological process	TAS[6334807]	34
GO:0048147	negative regulation of fibroblast proliferation	biological process	IEA	3
GO:0002876	positive regulation of chronic inflammatory response to antigenic stimulus	biological process	IEA	2

Gene related KEGG pathways (count: 3)

ID	Name	No. of Genes in PTSDgene
hsa04940	Type I diabetes mellitus	8
hsa04060	Cytokine-cytokine receptor interaction	9
hsa04612	Antigen processing and presentation	3

Gene related interactors from protein-protein interactions data in PINA v2 (count: 12)

Gene	Interactor	Interactor in PTSDgene?	Experiment Method	Interaction Type	PMID
LTA	TUBA1A	No	coimmunoprecipitation	colocalization	15129282 , 15129282 , 15129282 , 15129282 , 15129282
LTA	TNFRSF1B	No	biochemical	--	8182064 , 1328224 , 1310388 , 9552007
LTA	TUBA1B	No	--	--	15129282
LTA	LGALS2	No	coimmunoprecipitation	colocalization	15129282 , 15129282 , 15129282 , 15129282 , 15129282 , 15129282 , 15129282 , 15129282 , 15129282 , 15129282 , 15129282 , 15129282 , 15129282 , 15129282 , 15129282 , 15129282
LTA	TNFRSF1A	No	biochemical	association	2170974 , 8387891 , 1310388 , 8387891 , 8387891 , 8288897 , 8182064
LTA	TNF	Yes	coimmunoprecipitation	--	8171323
LTA	TUBA4A	No	--	--	15129282
LTA	LTBR	No	coimmunoprecipitation	--	8171323 , 8171323
LTA	CLSPN	No	--	--	18922873
LTA	UMOD	No	--	--	8323280 , 8323280
LTA	LTB	Yes	--	--	7995952 , 9317127 , 7995952 , 7995952 , 8621492 , 9235946
LTA	TNFRSF14	No	--	--	9153189 , 9462508