PTSDgene database

SNP Report

Basic Info
Name rs263234 dbSNP Ensembl
Location 8:130806469 - 130806469(+)
Variant Seq G
Ancestral Allele A
Ref Seq A
Minor Allele Frequence 0.201877
Annotation intron_variant
Variant Effect intron_variant(ENST00000286355, ENST00000377928)
SIFT Annotation deleterious; tolerated
SIFT Variant Effect deleterious(ENST00000286355); tolerated(ENST00000377928)
PolyPhen Annotation benign; probably_damaging
PolyPhen Variant Effect benign(ENST00000377928); probably_damaging(ENST00000286355)
rSNP? Yes Link in rVarBase
Related Regulatory Elements Chromatin interactive region
Chromatin State Weak transcription;Enhancers
No. of Marker's Association Results 1 (Positive: 0; Negative: 1; Trend: 0)
Source Literature

SNP related association results
Normal genetic study related association results (count: 1)
Reference Phenotype Statistical Values Author Comments Marker's Category
Wolf, E. J.,2014 Dissociative symptom severity P-value<0.05 P-value<0.05 Follow-up evaluation of ADCY8 revealed four other SNPs (rs43...... Follow-up evaluation of ADCY8 revealed four other SNPs (rs4339660, rs7015079, rs263238, and rs263234) that were nominally associated with dissociation severity (smallest P-value= .01). More... Non-significant

SNP related genes (count: 3)
Approved Symbol Approved Name Location No. of Association Results (Positive/Negative/Trend)
ZNF276 zinc finger protein 276 16q24.3 rSNP target
ADCY8 adenylate cyclase 8 (brain) 8q24 1(0/0/1)
VPS9D1 VPS9 domain containing 1 16q24.3 rSNP target

SNPs in LD with rs263234 (count: 9)
The LD data used here is based on 1000 Genome Phase I. LD SNP pairs were selected with a threshold r2<=0.8.

Literature-origin SNPs (count: 0)

LD-proxies (count: 9)

SNP related eQTL (count: 1)
Gene Symbol Gene Existed in PTSDgene? Tissue Trans/Cis Source
RP11-259G18.3 No Adipose Subcutaneous cis GTEx