SNP Report

Basic Info

Name	rs263232 dbSNP Ensembl
Location	8:130795923 - 130795923(+)
Variant Seq	A
Ancestral Allele	C
Ref Seq	C
Minor Allele Frequence	0.0391374
Annotation	intron_variant
Variant Effect	intron_variant(ENST00000286355, ENST00000377928)
SIFT Annotation	tolerated
SIFT Variant Effect	tolerated(ENST00000286355, ENST00000377928)
PolyPhen Annotation	probably_damaging
PolyPhen Variant Effect	probably_damaging(ENST00000286355, ENST00000377928)
rSNP?	Yes Link in rVarBase
Related Regulatory Elements	n/a
Chromatin State	Weak transcription;Enhancers
No. of Marker's Association Results	1 (Positive: 0; Negative: 0; Trend: 1)
Source	Literature

SNP related association results

Normal genetic study related association results (count: 1)

Reference	Phenotype	Statistical Values	Author Comments	Marker's Category
Wolf, E. J.,2014	Dissociative symptom severity	Linear regression: B=1.43, SE=0.28, P-value=6.12E-07, R Linear regression: B=1.43, SE=0.28, P-value=6.12E-07, R²=0.05. Controlling for PTSD severity: P-value=5.66E-07, modified by sex: P-value=0.09. More...	The SNP with the strongest association with dissociation. Th...... The SNP with the strongest association with dissociation. The effect of the SNP remained suggestive after controlling for PTSD severity and was not significantly modified by sex. More...	Trend

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Association Results (Positive/Negative/Trend)
ADCY8	adenylate cyclase 8 (brain)	8q24	1(0/0/1)

SNPs in LD with rs263232 (count: 1)

The LD data used here is based on 1000 Genome Phase I. LD SNP pairs were selected with a threshold r²<=0.8.

rs_ID	Literature-origin SNPs with LD	Annotation	r²[population]
rs190526	rs263232	intron_variant	0.9412[EUR]

SNP related eQTL (count: 1)

Gene Symbol	Gene Existed in PTSDgene?	Tissue	Trans/Cis	Source
RP11-259G18.3	No	Adipose Subcutaneous	cis	GTEx