PTSDgene database

SNP Report

Basic Info
Name rs263232 dbSNP Ensembl
Location 8:130795923 - 130795923(+)
Variant Seq A
Ancestral Allele C
Ref Seq C
Minor Allele Frequence 0.0391374
Annotation intron_variant
Variant Effect intron_variant(ENST00000286355, ENST00000377928)
SIFT Annotation tolerated
SIFT Variant Effect tolerated(ENST00000286355, ENST00000377928)
PolyPhen Annotation probably_damaging
PolyPhen Variant Effect probably_damaging(ENST00000286355, ENST00000377928)
rSNP? Yes Link in rVarBase
Related Regulatory Elements n/a
Chromatin State Weak transcription;Enhancers
No. of Marker's Association Results 1 (Positive: 0; Negative: 0; Trend: 1)
Source Literature

SNP related association results
Normal genetic study related association results (count: 1)
Reference Phenotype Statistical Values Author Comments Marker's Category
Wolf, E. J.,2014 Dissociative symptom severity Linear regression: B=1.43, SE=0.28, P-value=6.12E-07, R Linear regression: B=1.43, SE=0.28, P-value=6.12E-07, R2=0.05. Controlling for PTSD severity: P-value=5.66E-07, modified by sex: P-value=0.09. More... The SNP with the strongest association with dissociation. Th...... The SNP with the strongest association with dissociation. The effect of the SNP remained suggestive after controlling for PTSD severity and was not significantly modified by sex. More... Trend

SNP related genes (count: 1)
Approved Symbol Approved Name Location No. of Association Results (Positive/Negative/Trend)
ADCY8 adenylate cyclase 8 (brain) 8q24 1(0/0/1)

SNPs in LD with rs263232 (count: 1)
The LD data used here is based on 1000 Genome Phase I. LD SNP pairs were selected with a threshold r2<=0.8.

Literature-origin SNPs (count: 0)

LD-proxies (count: 1)

SNP related eQTL (count: 1)
Gene Symbol Gene Existed in PTSDgene? Tissue Trans/Cis Source
RP11-259G18.3 No Adipose Subcutaneous cis GTEx