Study Report
Study Information
Basic Info
| Reference |
Powers, A.,2016 PMID: 27643478
|
| Citation |
Powers, A., et al. (2016). "A genome-wide association study of emotion dysregulation: Evidence for interleukin 2 receptor alpha." J Psychiatr Res 83: 195-202. |
| Phenotype |
PTSD diagnosis |
| Trauma |
Various |
| Study Design |
Case-control |
| Study Type |
Candidate gene association study |
| Sample Size |
769 cases, 1831 controls |
| SNP/Marker Size |
1 SNP |
| Predominant Ethnicity |
Black |
| Population |
American |
| Gender |
774 males, 1826 females |
| Age |
Mean age=39 years |
Detail Info
| Sample Diagnosis |
DSM-IV-TR |
| Related Diagnostic Tools |
Emotional dysregulation scale (EDS), Modified PTSD symptom scale (mPSS), Beck depression inventary-II (BDI-II) |
| Sample Status |
Participants were recruited from the general medical clinics of a publicly funded hospital, as detailed previously (Gillespie et al., 2009). |
| Controls Exposed |
NS |
| Replication Size |
None |
| Result Summary |
The SNP rs6602398 was significantly associated with depression and PTSD. |
| Potential Biomarker |
None |
Genetic result reported by this study
Normal genetic result reported by this study (count: 1)
| Marker |
Phenotype |
Related Gene |
Statistical Values |
Author Comments |
Marker's Category |
|
rs6602398
|
Current PTSD |
IL2RA |
Not control for emotion dysregulation: B=0.73, OR=2.07, P-value<0.01. Control for emotion dysregulation: B=0.09, OR=1.265, P-value>0.05. |
Rs6602398 was significantly associated with current PTSD. Wh......
Rs6602398 was significantly associated with current PTSD. When emotion dysregulation symptoms were included in the model, the associations between rs6602398 and current PTSD was no longer significant.
More...
|
Significant |
