SNP Report
Basic Info
| Name | rs6602398 dbSNP Ensembl | ||
|---|---|---|---|
| Location | 10:6040990 - 6040990(+) | ||
| Variant Seq | T | ||
| Ancestral Allele | G | ||
| Ref Seq | G | ||
| Minor Allele Frequence | 0.161342 | ||
| Annotation | downstream_gene_variant; intron_variant | ||
| Variant Effect | downstream_gene_variant(ENST00000440436); intron_variant(ENST00000379954, LRG_73t1, ENST00000256876, ENST00000379959) | ||
| SIFT Annotation | deleterious | ||
| SIFT Variant Effect | deleterious(LRG_73t1, ENST00000447847, ENST00000379959, ENST00000379954, ENST00000256876) | ||
| PolyPhen Annotation | probably_damaging | ||
| PolyPhen Variant Effect | probably_damaging(LRG_73t1, ENST00000447847, ENST00000379959, ENST00000379954, ENST00000256876) | ||
| rSNP? | Yes Link in rVarBase | ||
| Related Regulatory Elements | n/a | ||
| Chromatin State | Weak transcription;Enhancers;Genic enhancers | ||
| No. of Marker's Association Results | 1 (Positive: 1; Negative: 0; Trend: 0) | ||
| Source | Literature | ||
SNP related association results
| Reference | Phenotype | Statistical Values | Author Comments | Marker's Category |
|---|---|---|---|---|
| Powers, A.,2016 | Current PTSD | Not control for emotion dysregulation: B=0.73, OR=2.07, P-va...... Not control for emotion dysregulation: B=0.73, OR=2.07, P-value<0.01. Control for emotion dysregulation: B=0.09, OR=1.265, P-value>0.05. More... | Rs6602398 was significantly associated with current PTSD. Wh...... Rs6602398 was significantly associated with current PTSD. When emotion dysregulation symptoms were included in the model, the associations between rs6602398 and current PTSD was no longer significant. More... | Significant |
SNP related genes (count: 1)
| Approved Symbol | Approved Name | Location | No. of Association Results (Positive/Negative/Trend)  |
|---|---|---|---|
| IL2RA | interleukin 2 receptor subunit alpha | 10p15-p14 | 1(1/0/0) |
SNPs in LD with rs6602398 (count: 5)
Literature-origin SNPs (count: 0)
LD-proxies (count: 5)
SNP related eQTL (count: 1)