Gene Report

Basic Info

Approved Symbol	IL2RA
Previous Symbol	"IL2R\|IDDM10"
Symbol Alias	CD25
Approved Name	interleukin 2 receptor subunit alpha
Previous Name	"insulin-dependent diabetes mellitus 10\|interleukin 2 receptor, alpha"
Location	10p15-p14
Position	chr10:6010689-6062325, -1
External Links	HGNC: 6008 Entrez Gene: 3559 Ensembl: ENSG00000134460 UCSC: uc001iiz.2
No. of Association Results	1 (Positive: 1; Negative: 0; trend: 0)
Annotation Type	Literature-origin, Mapped by Literature SNP, Mapped by LD-proxy

Gene related association results

Normal genetic study related association results (count: 1)

Reference	Phenotype	Marker	Gene's Category
Powers, A.,2016	Current PTSD	rs6602398	Significant

Gene functional annotation

Gene related GO terms (count: 36)

ID	Name	Type	Evidence[PMID]	No. of Genes in PTSDgene
GO:0006915	apoptotic process	biological process	TAS[9096364]	19
GO:0050777	negative regulation of immune response	biological process	IEA	2
GO:0038110	interleukin-2-mediated signaling pathway	biological process	IEA	2
GO:0050687	negative regulation of defense response to virus	biological process	IEA	1
GO:0007166	cell surface receptor signaling pathway	biological process	TAS[2983318]	16
GO:0007173	epidermal growth factor receptor signaling pathway	biological process	TAS	11
GO:0046013	regulation of T cell homeostatic proliferation	biological process	IEA	1
GO:0006955	immune response	biological process	TAS[9096364]	6
GO:0008543	fibroblast growth factor receptor signaling pathway	biological process	TAS	9
GO:0009897	external side of plasma membrane	cellular component	IEA	9
GO:0002437	inflammatory response to antigenic stimulus	biological process	IEA	3
GO:0004911	interleukin-2 receptor activity	molecular function	IEA	1
GO:0042104	positive regulation of activated T cell proliferation	biological process	IEA	1
GO:0007264	small GTPase mediated signal transduction	biological process	TAS	14
GO:0007219	Notch signaling pathway	biological process	IEA	4
GO:0005622	intracellular	cellular component	TAS	15
GO:0038095	Fc-epsilon receptor signaling pathway	biological process	TAS	8
GO:0006954	inflammatory response	biological process	IBA	10
GO:0008144	drug binding	molecular function	IEA	13
GO:0042130	negative regulation of T cell proliferation	biological process	IEA	3
GO:0019976	interleukin-2 binding	molecular function	IBA	1
GO:0016021	integral component of membrane	cellular component	IEA	56
GO:0045087	innate immune response	biological process	TAS	15
GO:0050728	negative regulation of inflammatory response	biological process	IEA	5
GO:0000165	MAPK cascade	biological process	TAS	10
GO:0048011	neurotrophin TRK receptor signaling pathway	biological process	TAS	11
GO:0008286	insulin receptor signaling pathway	biological process	TAS	8
GO:0007265	Ras protein signal transduction	biological process	TAS	8
GO:0002664	regulation of T cell tolerance induction	biological process	IMP[23416241]	1
GO:0048010	vascular endothelial growth factor receptor signaling pathway	biological process	TAS	9
GO:0005886	plasma membrane	cellular component	TAS	99
GO:0008283	cell proliferation	biological process	TAS[2983318]	9
GO:0000186	activation of MAPKK activity	biological process	TAS	7
GO:0045582	positive regulation of T cell differentiation	biological process	IEA	1
GO:0007411	axon guidance	biological process	TAS	16
GO:0006924	activation-induced cell death of T cells	biological process	IEA	1

Gene related KEGG pathways (count: 3)

ID	Name	No. of Genes in PTSDgene
hsa04630	Jak-STAT signaling pathway	5
hsa04640	Hematopoietic cell lineage	5
hsa04060	Cytokine-cytokine receptor interaction	9

Gene related interactors from protein-protein interactions data in PINA v2 (count: 9)

Gene	Interactor	Interactor in PTSDgene?	Experiment Method	Interaction Type	PMID
IL2RA	IL2	No	--	--	1993646
IL2RA	SNTA1	No	--	--	15123239
IL2RA	STAT3	No	--	--	10602027
IL2RA	CD4	No	--	--	7539755
IL2RA	STAT5B	No	--	--	10602027
IL2RA	ICAM1	No	--	--	1976256 , 1976256
IL2RA	NFKB1	No	--	--	2497520
IL2RA	PASK	No	--	--	21418524 , 21418524 , 21418524 , 21418524
IL2RA	IL2RB	No	biophysical	--	8006584 , 11886175