Study Report
Study Information
Basic Info
| Reference |
Morris, C. P.,2012 PMID: 22960338
|
| Citation |
Morris, C. P., et al. (2012). "KPNA3 variation is associated with schizophrenia, major depression, opiate dependence and alcohol dependence." Dis Markers 33(4): 163-170. |
| Phenotype |
PTSD |
| Trauma |
Vietnam combat |
| Study Design |
Case-control |
| Study Type |
Candidate gene association study |
| Sample Size |
121 cases, 237 controls |
| SNP/Marker Size |
1 SNP |
| Predominant Ethnicity |
Caucasian |
| Population |
Australian |
| Gender |
Case: all males, control: 139 males, 98 females |
| Age |
Case: mean age=52 years old, SD=6.2, controls: mean age=36.8 years old, SD=12.8 |
Detail Info
| Sample Diagnosis |
DSM-IV |
| Related Diagnostic Tools |
Mississippi Scale for combat-related PTSD. Patients were assessed for PTSD by a consultant psychiatristor a senior psychiatric registrar using DSM-IV criteria. |
| Sample Status |
Patients were excluded from the study if they had a diagnosis of psychosis, bipolar disorder, obsessive compulsive disorder,or organic brain syndrome including dementia. |
| Controls Exposed |
NS |
| Replication Size |
None |
| Result Summary |
The rs2273816 SNP was found to be not associated with PTSD. |
| Potential Biomarker |
None |
Genetic result reported by this study
Normal genetic result reported by this study (count: 1)
| Marker |
Phenotype |
Related Gene |
Statistical Values |
Author Comments |
Marker's Category |
|
rs2273816
|
PTSD |
KPNA3 |
Allele: X2=2.297, P-value=0.130, OR=1.47, 95%CI: 0.86-2.48. Genotype: P-value=0.074 |
The rs2273816 SNP was found to be not associated with PTSD.
The rs2273816 SNP was found to be not associated with PTSD.
|
Non-significant |
