Gene Report

Basic Info

Approved Symbol	SLC6A2
Previous Symbol	"NET1\|NAT1\|SLC6A5"
Symbol Alias	NET
Approved Name	solute carrier family 6 (neurotransmitter transporter), member 2
Previous Name	solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2
Name Alias	norepinephrine transporter
Location	16q12.2
Position	chr16:55655604-55706192, 1
External Links	HGNC: 11048 Entrez Gene: 6530 Ensembl: ENSG00000103546 UCSC: uc021tio.1
No. of Association Results	13 (Positive: 4; Negative: 9; trend: 0)
Annotation Type	Literature-origin, Mapped by Literature SNP, Mapped by LD-proxy

Gene related association results

Normal genetic study related association results (count: 13)

Reference	Phenotype	Marker	Gene's Category
Pietrzak, R. H.,2015	Anxious arousal symptoms	rs2242446	Significant
Pietrzak, R. H.,2015	Avoidance symptoms	rs2242446	Non-significant
Pietrzak, R. H.,2015	Count of anxious arousal symptoms	rs2242446	Significant
Pietrzak, R. H.,2015	Count of avoidance symptoms	rs2242446	Non-significant
Pietrzak, R. H.,2015	Count of dysphoric arousal symptoms	rs2242446	Non-significant
Pietrzak, R. H.,2015	Count of numbing symptoms	rs2242446	Non-significant
Pietrzak, R. H.,2015	Count of reexperiencing symptoms	rs2242446	Non-significant
Pietrzak, R. H.,2015	Dysphoric arousal symptoms	rs2242446	Non-significant
Pietrzak, R. H.,2015	Exaggerated Startle	rs2242446	Significant
Pietrzak, R. H.,2015	Hypervigilance	rs2242446	Significant
Pietrzak, R. H.,2015	Numbing symptoms	rs2242446	Non-significant
Pietrzak, R. H.,2015	PCL total score	rs2242446	Non-significant
Pietrzak, R. H.,2015	Reexperiencing symptoms	rs2242446	Non-significant

Gene functional annotation

Gene related GO terms (count: 16)

ID	Name	Type	Evidence[PMID]	No. of Genes in PTSDgene
GO:0015844	monoamine transport	biological process	IDA[16024787]	4
GO:0005887	integral component of plasma membrane	cellular component	IEA	36
GO:0007268	synaptic transmission	biological process	TAS[2008212]	32
GO:0005330	dopamine:sodium symporter activity	molecular function	IBA	2
GO:0055085	transmembrane transport	biological process	TAS	14
GO:0046872	metal ion binding	molecular function	IEA	20
GO:0048265	response to pain	biological process	IEA	4
GO:0005334	norepinephrine:sodium symporter activity	molecular function	TAS[2008212]	1
GO:0051583	dopamine uptake involved in synaptic transmission	biological process	IBA	2
GO:0015874	norepinephrine transport	biological process	IBA	1
GO:0005886	plasma membrane	cellular component	TAS	99
GO:0006810	transport	biological process	TAS[2008212]	8
GO:0016020	membrane	cellular component	TAS[2008212]	42
GO:0043005	neuron projection	cellular component	IBA	17
GO:0005515	protein binding	molecular function	IPI[11343649\|17156375]	169
GO:0008504	monoamine transmembrane transporter activity	molecular function	IDA[16024787]	4

Gene related KEGG pathways (count: 0)

Gene related interactors from protein-protein interactions data in PINA v2 (count: 5)

Gene	Interactor	Interactor in PTSDgene?	Experiment Method	Interaction Type	PMID
SLC6A2	PICK1	No	--	--	11343649 , 11343649 , 11343649 , 11343649 , 11343649 , 11343649 , 11343649 , 11343649 , 11343649
SLC6A2	ACTB	No	--	--	18331289 , 18331289
SLC6A2	STX1A	No	--	--	17032905 , 12629174
SLC6A2	SNCA	No	--	--	18331289 , 17156375 , 17156375 , 18331289
SLC6A2	PPP2R1A	No	--	--	15963952