PTSDgene database

Study Report

Study Information
Basic Info
Reference
Citation Pietrzak, R. H., et al. (2015). "Association of the rs2242446 polymorphism in the norepinephrine transporter gene SLC6A2 and anxious arousal symptoms of posttraumatic stress disorder." J Clin Psychiatry 76(4): e537-538.
Phenotype PCL total score, Reexperiencing symptoms, Avoidance score, Numbing score, Dysphoric arousal score, Anxious arousal score, Count of reexperiencing symptoms, Count of avoidance symptoms, Count of numbing symptoms, Count of dysphoric Arousal symptoms, Count of anxious arousal symptoms, Hypervigilance, Exaggerated Startle
Trauma Combat
Study Design Cross-sectional study
Study Type Candidate gene association study
Sample Size 580 samples
SNP/Marker Size 1 SNP
Predominant Ethnicity Black
Population 82.8% African American, 11.2% White, 6.0% Other
Gender 251 males, 329 females
Age Mean age= 52.4 years, SD=16.0

Detail Info

Genetic result reported by this study
Normal genetic result reported by this study (count: 13)
Marker Phenotype Related Gene Statistical Values Author Comments Marker's Category
rs2242446 Count of reexperiencing symptoms SLC6A2 B=-0.00, t=0.01, P-value=0.99 No significant association observed. No significant association observed. Non-significant
rs2242446 Count of numbing symptoms SLC6A2 B=0.01, t=0.29, P-value=0.78 No significant association observed. No significant association observed. Non-significant
rs2242446 Count of dysphoric arousal symptoms SLC6A2 B=0.05, t=1.36, P-value=0.17 No significant association observed. No significant association observed. Non-significant
rs2242446 Count of avoidance symptoms SLC6A2 B=0.03, t=0.86, P-value=0.39 No significant association observed. No significant association observed. Non-significant
rs2242446 Numbing symptoms SLC6A2 B=0.02, t=0.45, P-value=0.65 No significant association observed. No significant association observed. Non-significant
rs2242446 Dysphoric arousal symptoms SLC6A2 B=0.06, t=1.69, P-value=0.09 No significant association observed. No significant association observed. Non-significant
rs2242446 Avoidance symptoms SLC6A2 B=0.04, t=1.04, P-value=0.30 No significant association observed. No significant association observed. Non-significant
rs2242446 Exaggerated Startle SLC6A2 OR=1.76, t=3.24, P-value=0.001 Rs2242446 genotype significantly predicted Exaggerated Start...... Rs2242446 genotype significantly predicted Exaggerated Startle symptom. More... Significant
rs2242446 Anxious arousal symptoms SLC6A2 B=0.09, t=2.45, P-value=0.01 Rs2242446 genotype significantly predicted scale scores of ...... Rs2242446 genotype significantly predicted scale scores of anxious arousal symptoms. More... Significant
rs2242446 PCL total score SLC6A2 B=0.04, t=1.16, P-value= 0.25 No significant association observed. No significant association observed. Non-significant
rs2242446 Reexperiencing symptoms SLC6A2 B=0.01, t=0.17, P-value=0.87 No significant association observed. No significant association observed. Non-significant
rs2242446 Count of anxious arousal symptoms SLC6A2 B=0.12, t=3.04, P-value=0.002 Rs2242446 genotype significantly predicted count of anxious ...... Rs2242446 genotype significantly predicted count of anxious arousal symptoms. More... Significant
rs2242446 Hypervigilance SLC6A2 OR=1.41, t=2.12, P-value=0.03 Rs2242446 genotype significantly predicted Hypervigilance sy...... Rs2242446 genotype significantly predicted Hypervigilance symptom. More... Significant