PTSDgene database

Pathway Enrichment Analysis Protein-Protein Interaction Analysis

Study Report

Study Information

Basic Info

Reference	Pietrzak, R. H.,2015 PMID: 25919853
Citation	Pietrzak, R. H., et al. (2015). "Association of the rs2242446 polymorphism in the norepinephrine transporter gene SLC6A2 and anxious arousal symptoms of posttraumatic stress disorder." J Clin Psychiatry 76(4): e537-538.
Phenotype	PCL total score, Reexperiencing symptoms, Avoidance score, Numbing score, Dysphoric arousal score, Anxious arousal score, Count of reexperiencing symptoms, Count of avoidance symptoms, Count of numbing symptoms, Count of dysphoric Arousal symptoms, Count of anxious arousal symptoms, Hypervigilance, Exaggerated Startle
Trauma	Combat
Study Design	Cross-sectional study
Study Type	Candidate gene association study
Sample Size	580 samples
SNP/Marker Size	1 SNP
Predominant Ethnicity	Black
Population	82.8% African American, 11.2% White, 6.0% Other
Gender	251 males, 329 females
Age	Mean age= 52.4 years, SD=16.0

Detail Info

Genetic result reported by this study

Normal genetic result reported by this study (count: 13)

Marker	Phenotype	Related Gene	Statistical Values	Author Comments	Marker's Category
rs2242446	Count of reexperiencing symptoms	SLC6A2	B=-0.00, t=0.01, P-value=0.99	No significant association observed. No significant association observed.	Non-significant
rs2242446	Count of numbing symptoms	SLC6A2	B=0.01, t=0.29, P-value=0.78	No significant association observed. No significant association observed.	Non-significant
rs2242446	Count of dysphoric arousal symptoms	SLC6A2	B=0.05, t=1.36, P-value=0.17	No significant association observed. No significant association observed.	Non-significant
rs2242446	Count of avoidance symptoms	SLC6A2	B=0.03, t=0.86, P-value=0.39	No significant association observed. No significant association observed.	Non-significant
rs2242446	Numbing symptoms	SLC6A2	B=0.02, t=0.45, P-value=0.65	No significant association observed. No significant association observed.	Non-significant
rs2242446	Dysphoric arousal symptoms	SLC6A2	B=0.06, t=1.69, P-value=0.09	No significant association observed. No significant association observed.	Non-significant
rs2242446	Avoidance symptoms	SLC6A2	B=0.04, t=1.04, P-value=0.30	No significant association observed. No significant association observed.	Non-significant
rs2242446	Exaggerated Startle	SLC6A2	OR=1.76, t=3.24, P-value=0.001	Rs2242446 genotype significantly predicted Exaggerated Start...... Rs2242446 genotype significantly predicted Exaggerated Startle symptom. More...	Significant
rs2242446	Anxious arousal symptoms	SLC6A2	B=0.09, t=2.45, P-value=0.01	Rs2242446 genotype significantly predicted scale scores of ...... Rs2242446 genotype significantly predicted scale scores of anxious arousal symptoms. More...	Significant
rs2242446	PCL total score	SLC6A2	B=0.04, t=1.16, P-value= 0.25	No significant association observed. No significant association observed.	Non-significant
rs2242446	Reexperiencing symptoms	SLC6A2	B=0.01, t=0.17, P-value=0.87	No significant association observed. No significant association observed.	Non-significant
rs2242446	Count of anxious arousal symptoms	SLC6A2	B=0.12, t=3.04, P-value=0.002	Rs2242446 genotype significantly predicted count of anxious ...... Rs2242446 genotype significantly predicted count of anxious arousal symptoms. More...	Significant
rs2242446	Hypervigilance	SLC6A2	OR=1.41, t=2.12, P-value=0.03	Rs2242446 genotype significantly predicted Hypervigilance sy...... Rs2242446 genotype significantly predicted Hypervigilance symptom. More...	Significant