Gene Report

Basic Info

Approved Symbol	PIK3C2A
Symbol Alias	PI3K-C2alpha
Approved Name	phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha
Previous Name	"phosphoinositide-3-kinase, class 2, alpha polypeptide\|phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha"
Location	11p15.5-p14
Position	chr11:17077730-17207983, -1
External Links	HGNC: 8971 Entrez Gene: 5286 Ensembl: ENSG00000011405 UCSC: uc001mmq.5
No. of Association Results	0. Gene is from "rSNP target"
Annotation Type	rSNP target

Gene functional annotation

Gene related GO terms (count: 30)

ID	Name	Type	Evidence[PMID]	No. of Genes in PTSDgene
GO:0035005	1-phosphatidylinositol-4-phosphate 3-kinase activity	molecular function	IBA; TAS	1
GO:0005634	nucleus	cellular component	IEA	81
GO:0070062	extracellular exosome	cellular component	IDA[19056867]	58
GO:0035004	phosphatidylinositol 3-kinase activity	molecular function	TAS[17371240]	1
GO:0006887	exocytosis	biological process	TAS[17371240]	5
GO:0014829	vascular smooth muscle contraction	biological process	TAS[17371240]	1
GO:0071583	negative regulation of zinc ion transmembrane transport	biological process	IEA	1
GO:0005794	Golgi apparatus	cellular component	IEA	17
GO:0046854	phosphatidylinositol phosphorylation	biological process	IEA	1
GO:0014065	phosphatidylinositol 3-kinase signaling	biological process	IBA	2
GO:0036092	phosphatidylinositol-3-phosphate biosynthetic process	biological process	IEA	1
GO:0035091	phosphatidylinositol binding	molecular function	IEA	1
GO:0016477	cell migration	biological process	IBA	6
GO:0005524	ATP binding	molecular function	IEA	23
GO:0016303	1-phosphatidylinositol-3-kinase activity	molecular function	IEA	1
GO:0005886	plasma membrane	cellular component	IDA[21081650]	99
GO:0007173	epidermal growth factor receptor signaling pathway	biological process	TAS[17371240]	11
GO:0006644	phospholipid metabolic process	biological process	TAS	2
GO:0030136	clathrin-coated vesicle	cellular component	IEA	2
GO:0016020	membrane	cellular component	IDA[19946888]	42
GO:0048268	clathrin coat assembly	biological process	TAS[17371240]	1
GO:0008286	insulin receptor signaling pathway	biological process	TAS[17371240]	8
GO:0005737	cytoplasm	cellular component	IDA[21081650]	109
GO:0006661	phosphatidylinositol biosynthetic process	biological process	TAS	1
GO:0044281	small molecule metabolic process	biological process	TAS	38
GO:0005942	phosphatidylinositol 3-kinase complex	cellular component	IBA	1
GO:0031982	vesicle	cellular component	IDA[21081650]	7
GO:0048008	platelet-derived growth factor receptor signaling pathway	biological process	TAS[17371240]	1
GO:0005829	cytosol	cellular component	TAS	78
GO:0006897	endocytosis	biological process	IMP[21081650]	3

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in PTSDgene
hsa04070	Phosphatidylinositol signaling system	2

Gene related interactors from protein-protein interactions data in PINA v2 (count: 21)

Gene	Interactor	Interactor in PTSDgene?	Experiment Method	Interaction Type	PMID
PIK3C2A	YWHAB	No	--	association	24255178 , 24255178 , 24255178
PIK3C2A	ANKFY1	No	--	--	20562859
PIK3C2A	TRIM27	No	--	--	22128329
PIK3C2A	TKT	No	--	--	20562859
PIK3C2A	EIF3A	No	--	--	20562859
PIK3C2A	ATG7	No	--	--	20562859
PIK3C2A	UBC	No	--	--	21906983 , 22505724 , 21963094 , 23000965 , 21890473 , 21139048
PIK3C2A	MLH1	No	--	--	17148452
PIK3C2A	AMOT	No	--	--	23414517
PIK3C2A	TARS	No	--	--	20562859
PIK3C2A	EGFR	No	--	association	10805725 , 10805725
PIK3C2A	PA2G4	No	--	--	20562859
PIK3C2A	FKBP4	No	--	--	20562859
PIK3C2A	MAP1LC3A	No	--	--	20562859 , 20562859
PIK3C2A	ERBB2	No	--	association	10805725 , 10805725
PIK3C2A	ARRB2	No	--	--	17620599
PIK3C2A	STAMBP	No	--	--	19615732 , 19615732
PIK3C2A	ARRB1	Yes	--	--	17620599
PIK3C2A	PGK1	No	--	--	20562859
PIK3C2A	PMS1	No	--	--	17148452
PIK3C2A	PMS2	No	--	--	17148452