Gene Report

Basic Info

Approved Symbol	NOD1
Previous Symbol	CARD4
Symbol Alias	"NLRC1\|CLR7.1"
Approved Name	nucleotide binding oligomerization domain containing 1
Previous Name	caspase recruitment domain family, member 4
Name Alias	"nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 1\|NLR family, CARD domain containing 1"
Location	7p14.3
Position	chr7:30424527-30478784, -1
External Links	HGNC: 16390 Entrez Gene: 10392 Ensembl: ENSG00000106100 UCSC: uc003tav.3
No. of Association Results	0. Gene is from "rSNP target"
Annotation Type	rSNP target

Gene functional annotation

Gene related GO terms (count: 53)

ID	Name	Type	Evidence[PMID]	No. of Genes in PTSDgene
GO:0006954	inflammatory response	biological process	TAS[15967716]	10
GO:0050830	defense response to Gram-positive bacterium	biological process	IEA	6
GO:0042834	peptidoglycan binding	molecular function	TAS[15967716]	1
GO:1901224	positive regulation of NIK/NF-kappaB signaling	biological process	IMP[25093298]	2
GO:0042803	protein homodimerization activity	molecular function	IPI[18186648]	18
GO:0035872	nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway	biological process	TAS	2
GO:0051092	positive regulation of NF-kappaB transcription factor activity	biological process	IDA[17054981\|19043560]; TAS	8
GO:0051259	protein oligomerization	biological process	TAS[15967716]	2
GO:0035556	intracellular signal transduction	biological process	IDA[15653568]	10
GO:0050700	CARD domain binding	molecular function	IDA[10329646]	1
GO:0070374	positive regulation of ERK1 and ERK2 cascade	biological process	IEA	10
GO:0006952	defense response	biological process	TAS[15967716]	1
GO:0035666	TRIF-dependent toll-like receptor signaling pathway	biological process	TAS	2
GO:0032760	positive regulation of tumor necrosis factor production	biological process	IEA	2
GO:0005737	cytoplasm	cellular component	IDA[10329646]; TAS[15967716]	109
GO:0042228	interleukin-8 biosynthetic process	biological process	IDA[15653568]	1
GO:0034134	toll-like receptor 2 signaling pathway	biological process	TAS	2
GO:0032755	positive regulation of interleukin-6 production	biological process	IEA	5
GO:0016323	basolateral plasma membrane	cellular component	IDA[19043560]	6
GO:0009595	detection of biotic stimulus	biological process	TAS[15967716]	1
GO:0002606	positive regulation of dendritic cell antigen processing and presentation	biological process	ISS	1
GO:0032731	positive regulation of interleukin-1 beta production	biological process	IEA	1
GO:0016045	detection of bacterium	biological process	IDA[15653568]	1
GO:0034146	toll-like receptor 5 signaling pathway	biological process	TAS	2
GO:0005515	protein binding	molecular function	IPI[15107016\|15657077\|19043560\|19337385\|23935490]	169
GO:0071225	cellular response to muramyl dipeptide	biological process	IMP[25093298]	1
GO:0038123	toll-like receptor TLR1:TLR2 signaling pathway	biological process	TAS	2
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	biological process	IDA[10329646]	5
GO:0007165	signal transduction	biological process	TAS[15967716]	34
GO:0002756	MyD88-independent toll-like receptor signaling pathway	biological process	TAS	2
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	biological process	IDA[10329646]	5
GO:0005829	cytosol	cellular component	TAS	78
GO:0042742	defense response to bacterium	biological process	IDA[15653568]	2
GO:0051403	stress-activated MAPK cascade	biological process	TAS	2
GO:0002224	toll-like receptor signaling pathway	biological process	TAS	2
GO:0034142	toll-like receptor 4 signaling pathway	biological process	TAS	2
GO:0045087	innate immune response	biological process	TAS	15
GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	biological process	IDA[10329646]	3
GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process	molecular function	TAS[10329646]	1
GO:0007254	JNK cascade	biological process	TAS	3
GO:0034138	toll-like receptor 3 signaling pathway	biological process	TAS	3
GO:0051000	positive regulation of nitric-oxide synthase activity	biological process	IEA	4
GO:0000187	activation of MAPK activity	biological process	TAS	8
GO:0005524	ATP binding	molecular function	IEA	23
GO:0046330	positive regulation of JNK cascade	biological process	IEA	3
GO:0002755	MyD88-dependent toll-like receptor signaling pathway	biological process	TAS	2
GO:0006915	apoptotic process	biological process	TAS[10329646]	19
GO:0038124	toll-like receptor TLR6:TLR2 signaling pathway	biological process	TAS	2
GO:0070423	nucleotide-binding oligomerization domain containing signaling pathway	biological process	TAS	2
GO:0042802	identical protein binding	molecular function	IDA[10329646]; IPI[18186648]	10
GO:0034162	toll-like receptor 9 signaling pathway	biological process	TAS	2
GO:0034166	toll-like receptor 10 signaling pathway	biological process	TAS	2
GO:0016324	apical plasma membrane	cellular component	IEA	6

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in PTSDgene
hsa05120	Epithelial cell signaling in Helicobacter pylori infection	1

Gene related interactors from protein-protein interactions data in PINA v2 (count: 2)

Gene	Interactor	Interactor in PTSDgene?	Experiment Method	Interaction Type	PMID
NOD1	MAGED1	No	--	--	17353931
NOD1	SUGT1	No	--	--	17420470 , 17435760 , 17420470