Gene Report

Basic Info

Approved Symbol	IFNG
Approved Name	interferon, gamma
Location	12q14
Position	chr12:68154768-68159747, -1
External Links	HGNC: 5438 Entrez Gene: 3458 Ensembl: ENSG00000111537 UCSC: uc001stw.1
No. of Association Results	0. Gene is from "Mapped by Literature SNP, Mapped by LD-proxy"
Annotation Type	Mapped by Literature SNP, Mapped by LD-proxy

Gene functional annotation

Gene related GO terms (count: 73)

ID	Name	Type	Evidence[PMID]	No. of Genes in PTSDgene
GO:0007050	cell cycle arrest	biological process	IDA[16942485]	4
GO:0042742	defense response to bacterium	biological process	IEA	2
GO:0030593	neutrophil chemotaxis	biological process	IEA	3
GO:0010628	positive regulation of gene expression	biological process	IDA[11487543\|20209097\|23817958]	14
GO:0010508	positive regulation of autophagy	biological process	IDA[26347139]	1
GO:0045080	positive regulation of chemokine biosynthetic process	biological process	IEA	3
GO:0030968	endoplasmic reticulum unfolded protein response	biological process	IEA	2
GO:0009615	response to virus	biological process	IDA[16280321]	4
GO:0031642	negative regulation of myelination	biological process	IEA	1
GO:0032735	positive regulation of interleukin-12 production	biological process	IDA[7605994\|8557999]	2
GO:0042511	positive regulation of tyrosine phosphorylation of Stat1 protein	biological process	IDA[15604419\|16280321]	1
GO:0045410	positive regulation of interleukin-6 biosynthetic process	biological process	IEA	2
GO:0042102	positive regulation of T cell proliferation	biological process	IEA	2
GO:0051044	positive regulation of membrane protein ectodomain proteolysis	biological process	IDA[18373975]	4
GO:0032760	positive regulation of tumor necrosis factor production	biological process	IEA	2
GO:0008284	positive regulation of cell proliferation	biological process	ISS	14
GO:0042493	response to drug	biological process	IEA	25
GO:0032834	positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response	biological process	IDA[20209097]	1
GO:0060334	regulation of interferon-gamma-mediated signaling pathway	biological process	TAS	2
GO:0045429	positive regulation of nitric oxide biosynthetic process	biological process	IDA[8383325]	5
GO:0019882	antigen processing and presentation	biological process	IEA	3
GO:0060557	positive regulation of vitamin D biosynthetic process	biological process	IDA[9282826]	2
GO:0050718	positive regulation of interleukin-1 beta secretion	biological process	IEA	1
GO:0000060	protein import into nucleus, translocation	biological process	IDA[15604419]	3
GO:0032747	positive regulation of interleukin-23 production	biological process	IDA[20027291]	1
GO:0032224	positive regulation of synaptic transmission, cholinergic	biological process	IEA	1
GO:0048304	positive regulation of isotype switching to IgG isotypes	biological process	IEA	1
GO:0060552	positive regulation of fructose 1,6-bisphosphate metabolic process	biological process	IDA[9282826]	1
GO:0097191	extrinsic apoptotic signaling pathway	biological process	IDA[16942485]	3
GO:0010629	negative regulation of gene expression	biological process	IDA[23817958]	3
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	biological process	IEA	25
GO:0045672	positive regulation of osteoclast differentiation	biological process	IDA[16220542]	2
GO:0051712	positive regulation of killing of cells of other organism	biological process	IDA[7544003]	1
GO:0009897	external side of plasma membrane	cellular component	IEA	9
GO:0045348	positive regulation of MHC class II biosynthetic process	biological process	IEA	1
GO:0071222	cellular response to lipopolysaccharide	biological process	IEA	2
GO:0045084	positive regulation of interleukin-12 biosynthetic process	biological process	IEA	2
GO:0032700	negative regulation of interleukin-17 production	biological process	IDA[18501882]	1
GO:0010634	positive regulation of epithelial cell migration	biological process	IDA[11698262]	1
GO:0050796	regulation of insulin secretion	biological process	IDA[8383325]	6
GO:0005125	cytokine activity	molecular function	IBA	7
GO:0006928	movement of cell or subcellular component	biological process	TAS[10477596]	3
GO:0045666	positive regulation of neuron differentiation	biological process	IEA	1
GO:0005133	interferon-gamma receptor binding	molecular function	IEA	1
GO:0005622	intracellular	cellular component	IDA[15604419]	15
GO:2000309	positive regulation of tumor necrosis factor (ligand) superfamily member 11 production	biological process	IDA[16220542]	1
GO:0034393	positive regulation of smooth muscle cell apoptotic process	biological process	IDA[16942485]	2
GO:0044130	negative regulation of growth of symbiont in host	biological process	IEA	3
GO:0007166	cell surface receptor signaling pathway	biological process	TAS[10477596]	16
GO:0002302	CD8-positive, alpha-beta T cell differentiation involved in immune response	biological process	IEA	1
GO:0019221	cytokine-mediated signaling pathway	biological process	TAS	9
GO:0060559	positive regulation of calcidiol 1-monooxygenase activity	biological process	IDA[9282826]	3
GO:0050954	sensory perception of mechanical stimulus	biological process	IEA	1
GO:0001781	neutrophil apoptotic process	biological process	IEA	1
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	biological process	ISS	16
GO:0071351	cellular response to interleukin-18	biological process	IEA	1
GO:0002250	adaptive immune response	biological process	IBA	2
GO:0060550	positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity	biological process	IDA[9282826]	1
GO:0033141	positive regulation of peptidyl-serine phosphorylation of STAT protein	biological process	IDA[16280321]; NAS[21268089]	1
GO:0002026	regulation of the force of heart contraction	biological process	IEA	2
GO:0060333	interferon-gamma-mediated signaling pathway	biological process	TAS	5
GO:0005576	extracellular region	cellular component	IDA[20041150]; TAS	31
GO:0042832	defense response to protozoan	biological process	IEA	1
GO:0098908	regulation of neuronal action potential	biological process	IEA	1
GO:0005615	extracellular space	cellular component	IBA	27
GO:0051607	defense response to virus	biological process	IEA	1
GO:0090004	positive regulation of establishment of protein localization to plasma membrane	biological process	IDA[11487543]	1
GO:1903543	positive regulation of exosomal secretion	biological process	IDA[11487543]	1
GO:0006959	humoral immune response	biological process	IBA	3
GO:0006915	apoptotic process	biological process	IGI[7828849]	19
GO:2000345	regulation of hepatocyte proliferation	biological process	IEA	1
GO:0048662	negative regulation of smooth muscle cell proliferation	biological process	IDA[16942485]	2
GO:0030857	negative regulation of epithelial cell differentiation	biological process	ISS	1

Gene related KEGG pathways (count: 10)

ID	Name	No. of Genes in PTSDgene
hsa04140	Regulation of autophagy	1
hsa04940	Type I diabetes mellitus	8
hsa04630	Jak-STAT signaling pathway	5
hsa04350	TGF-beta signaling pathway	2
hsa04650	Natural killer cell mediated cytotoxicity	7
hsa04660	T cell receptor signaling pathway	3
hsa04060	Cytokine-cytokine receptor interaction	9
hsa05330	Allograft rejection	5
hsa05332	Graft-versus-host disease	7
hsa05322	Systemic lupus erythematosus	3

Gene related interactors from protein-protein interactions data in PINA v2 (count: 4)

Gene	Interactor	Interactor in PTSDgene?	Experiment Method	Interaction Type	PMID
IFNG	STAT6	No	--	--	9651359
IFNG	IFNGR2	No	--	--	7673114 , 7673114
IFNG	PDIA3	No	--	--	8974399
IFNG	IFNGR1	No	--	association	12165521 , 10986460 , 7673114 , 11250200 , 10860730