Gene Report

Basic Info

Approved Symbol	EPHX2
Approved Name	epoxide hydrolase 2
Previous Name	epoxide hydrolase 2, cytoplasmic
Location	8p21
Position	chr8:27490779-27545564, 1
External Links	HGNC: 3402 Entrez Gene: 2053 Ensembl: ENSG00000120915 UCSC: uc003xfu.4
No. of Association Results	0. Gene is from "Mapped by LD-proxy, rSNP target"
Annotation Type	Mapped by LD-proxy, rSNP target

Gene functional annotation

Gene related GO terms (count: 29)

ID	Name	Type	Evidence[PMID]	No. of Genes in PTSDgene
GO:0004301	epoxide hydrolase activity	molecular function	IDA[8342951\|10862610]; TAS	1
GO:0046839	phospholipid dephosphorylation	biological process	IDA[12574510]	1
GO:0015643	toxic substance binding	molecular function	IDA[15096040]	2
GO:0042803	protein homodimerization activity	molecular function	IDA[15096040\|18513744]; NAS[10862610]	18
GO:0010628	positive regulation of gene expression	biological process	IDA[18974052]	14
GO:0005777	peroxisome	cellular component	IDA[16314446\|18513744]	3
GO:0006805	xenobiotic metabolic process	biological process	NAS[10862610]	9
GO:0008217	regulation of blood pressure	biological process	NAS[10862610]	5
GO:0033885	10-hydroxy-9-(phosphonooxy)octadecanoate phosphatase activity	molecular function	IEA	1
GO:0042632	cholesterol homeostasis	biological process	IDA[18974052]	8
GO:0070062	extracellular exosome	cellular component	IDA[19056867\|23376485\|23533145]	58
GO:0019373	epoxygenase P450 pathway	biological process	TAS	1
GO:0017144	drug metabolic process	biological process	NAS[10862610]	1
GO:0044281	small molecule metabolic process	biological process	TAS	38
GO:0005829	cytosol	cellular component	IDA[8342951\|16314446\|18513744]; NAS[10862610]; TAS	78
GO:0000287	magnesium ion binding	molecular function	IDA[12574510]	6
GO:0016311	dephosphorylation	biological process	IDA[12574508]	2
GO:0072593	reactive oxygen species metabolic process	biological process	NAS[10862610]	1
GO:0006874	cellular calcium ion homeostasis	biological process	NAS[10862610]	9
GO:0006954	inflammatory response	biological process	NAS[10862610]	10
GO:0019369	arachidonic acid metabolic process	biological process	TAS	3
GO:0005102	receptor binding	molecular function	IPI[20178365]	13
GO:0005737	cytoplasm	cellular component	IDA	109
GO:0042577	lipid phosphatase activity	molecular function	IDA[12574510]	1
GO:0045909	positive regulation of vasodilation	biological process	NAS[10862610]	5
GO:0046272	stilbene catabolic process	biological process	IDA[8342951]	1
GO:0009636	response to toxic substance	biological process	NAS[10862610]	10
GO:0090181	regulation of cholesterol metabolic process	biological process	IMP[18974052]	1
GO:0016791	phosphatase activity	molecular function	IDA[12574508\|15196990]	1

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in PTSDgene
hsa00590	Arachidonic acid metabolism	1
hsa00625	Tetrachloroethene degradation	1

Gene related interactors from protein-protein interactions data in PINA v2 (count: 4)

Gene	Interactor	Interactor in PTSDgene?	Experiment Method	Interaction Type	PMID
EPHX2	PEX5	No	--	--	20178365
EPHX2	MVP	No	--	--	21988832 , 21988832
EPHX2	TERF1	No	--	--	21044950
EPHX2	NIPSNAP3A	No	--	--	16169070 , 16169070 , 16169070 , 16169070