Gene Report

Basic Info

Approved Symbol	CCK
Approved Name	cholecystokinin
Name Alias	"prepro-cholecystokinin\|cholecystokinin triacontatriapeptide"
Location	3p22.1
Position	chr3:42257825-42266207, -1
External Links	HGNC: 1569 Entrez Gene: 885 Ensembl: ENSG00000187094 UCSC: uc021wwk.1
No. of Association Results	1 (Positive: 1; Negative: 0; trend: 0)
Annotation Type	Literature-origin, Mapped by Literature SNP, Mapped by LD-proxy, rSNP target

Gene related association results

Normal genetic study related association results (count: 1)

Reference	Phenotype	Marker	Gene's Category
Badour, C. L.,2015	PTSD diagnosis	rs1799923	Significant

Gene functional annotation

Gene related GO terms (count: 26)

ID	Name	Type	Evidence[PMID]	No. of Genes in PTSDgene
GO:0043203	axon hillock	cellular component	IEA	1
GO:0005615	extracellular space	cellular component	IEA	27
GO:0051901	positive regulation of mitochondrial depolarization	biological process	IEA	1
GO:0007409	axonogenesis	biological process	ISS[15152034]	6
GO:0043195	terminal bouton	cellular component	IEA	7
GO:0032461	positive regulation of protein oligomerization	biological process	IEA	2
GO:0005179	hormone activity	molecular function	TAS[10320330]	2
GO:0005576	extracellular region	cellular component	TAS	31
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	biological process	IEA	4
GO:0030425	dendrite	cellular component	IEA	19
GO:0014049	positive regulation of glutamate secretion	biological process	IEA	1
GO:0042755	eating behavior	biological process	ISS[15374756]	4
GO:0005184	neuropeptide hormone activity	molecular function	ISS[15374756]	4
GO:0043204	perikaryon	cellular component	IEA	6
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	biological process	IEA	5
GO:0043194	axon initial segment	cellular component	IEA	2
GO:0001764	neuron migration	biological process	ISS[15152034]	3
GO:0007165	signal transduction	biological process	TAS[10320330]	34
GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway	biological process	IEA	2
GO:0001836	release of cytochrome c from mitochondria	biological process	IEA	3
GO:0005515	protein binding	molecular function	IPI[23597562]	169
GO:0032099	negative regulation of appetite	biological process	IEA	1
GO:0008284	positive regulation of cell proliferation	biological process	IEA	14
GO:0001662	behavioral fear response	biological process	IEA	7
GO:0030424	axon	cellular component	ISS[15152034]	16
GO:0051930	regulation of sensory perception of pain	biological process	IEA	5

Gene related KEGG pathways (count: 0)

Gene related interactors from protein-protein interactions data in PINA v2 (count: 7)

Gene	Interactor	Interactor in PTSDgene?	Experiment Method	Interaction Type	PMID
CCK	CCKBR	No	--	--	15001692 , 12695525 , 15520004 , 10438490 , 23597562 , 23597562
CCK	UBC	No	--	--	21139048
CCK	MEP1A	No	--	--	11278902
CCK	MEP1B	No	--	--	11278902
CCK	ENPEP	No	--	--	8804068
CCK	CPE	No	--	--	9275097
CCK	CCKAR	No	--	--	10400673 , 10400673