Study Report
Study Information
Basic Info
| Reference |
Badour, C. L.,2015 PMID: 26454231
|
| Citation |
Badour, C. L., et al. (2015). "Exploring the association between a cholecystokinin promoter polymorphism (rs1799923) and posttraumatic stress disorder in combat veterans." J Anxiety Disord 36: 78-83. |
| Phenotype |
PTSD diagnosis |
| Trauma |
Combat |
| Study Design |
Case-control |
| Study Type |
Candidate gene association study |
| Sample Size |
298 cases, 159 controls |
| SNP/Marker Size |
1 SNP |
| Predominant Ethnicity |
Caucasian, Black |
| Population |
315 White, 111 African American |
| Gender |
82.3% males, 17.7% females |
| Age |
Case: mean age= 44.52 years, SD=14.75, Control: mean age= 43.95 years, SD=14.78 |
Detail Info
| Sample Diagnosis |
DSM-IV |
| Related Diagnostic Tools |
Combat exposure scale (CES). |
| Sample Status |
Caucasian, Black |
| Controls Exposed |
Yes |
| Replication Size |
None |
| Result Summary |
Results demonstrated that participants with either the heterozygous or homozygous T allele had an increased prevalence of PTSD relative to participants with the CC genotype. |
| Potential Biomarker |
None |
Genetic result reported by this study
Normal genetic result reported by this study (count: 1)
| Marker |
Phenotype |
Related Gene |
Statistical Values |
Author Comments |
Marker's Category |
|
rs1799923
|
PTSD diagnosis |
CCK |
B=0.77, OR= 2.17; 95% CI=[1.37-3.43], P-value< 0.01, controlling for combat exposure and recruitment site: B=0.68, OR = 1.97, P-value= .006, 95% CI: [1.21-3.19], among the subsample of white participants: B=0.88, OR= 2.50, P-value= 0.002, 95% CI: [1.42-4.40]. |
Specifically, relative to individuals with the CC genotype, ......
Specifically, relative to individuals with the CC genotype, those with the homozygous or heterozygous T allele were estimated to be 2.17 times more likely to have PTSD. This model remained significant when controlling for combat exposure and recruitment site. Among the subsample of White participants, those with the homozygous or heterozygous T allele were 2.50 times more likely to meet criteria for a PTSD diagnosis.
More...
|
Significant |
