Badour, C. L.,2015 PMID: 26454231
||Badour, C. L., et al. (2015). "Exploring the association between a cholecystokinin promoter polymorphism (rs1799923) and posttraumatic stress disorder in combat veterans." J Anxiety Disord 36: 78-83.
||Candidate gene association study
||298 cases, 159 controls
||315 White, 111 African American
||82.3% males, 17.7% females
||Case: mean age= 44.52 years, SD=14.75, Control: mean age= 43.95 years, SD=14.78
Genetic result reported by this study
Normal genetic result reported by this study (count: 1)
||B=0.77, OR= 2.17; 95% CI=[1.37-3.43], P-value< 0.01, controlling for combat exposure and recruitment site: B=0.68, OR = 1.97, P-value= .006, 95% CI: [1.21-3.19], among the subsample of white participants: B=0.88, OR= 2.50, P-value= 0.002, 95% CI: [1.42-4.40].
Specifically, relative to individuals with the CC genotype, ......
Specifically, relative to individuals with the CC genotype, those with the homozygous or heterozygous T allele were estimated to be 2.17 times more likely to have PTSD. This model remained significant when controlling for combat exposure and recruitment site. Among the subsample of White participants, those with the homozygous or heterozygous T allele were 2.50 times more likely to meet criteria for a PTSD diagnosis.