Study Report
Study Information
Basic Info
| Reference |
Hovhannisyan, L.,2017 PMID: 28681202
|
| Citation |
Hovhannisyan, L., et al. (2017). "Genetic variability of interleukin-1 beta as prospective factor from developing post-traumatic stress disorder." Immunogenetics 69(10): 703-708. |
| Phenotype |
PTSD diagnosis |
| Trauma |
Karabakh combat |
| Study Design |
Case-control |
| Study Type |
Candidate gene association study |
| Sample Size |
197 cases, 150 controls |
| SNP/Marker Size |
5 SNPs |
| Predominant Ethnicity |
Caucasian |
| Population |
Armenian |
| Gender |
347 males, 0 females |
| Age |
Case: mean age=54.52 years,SD=11.0, Control: mean age=42.6 years,SD=9.2 |
Detail Info
| Sample Diagnosis |
DSM-IV |
| Related Diagnostic Tools |
Structured Clinical Interview for DSM-IV Disorders (SCID), Clinician-Administered PTSD Scale (CAPS) |
| Sample Status |
The exclusion criteria for healthy controlswere participant reports on immune, cardiovascular, cerebrovascular, metabolic, oncological or kidney disorders, current cold, respiratory or other infections. |
| Controls Exposed |
No |
| Replication Size |
None |
| Result Summary |
IL1B rs1143633 and rs16944 SNPs are negatively associated with PTSD which allows us to consider them as protective variants for PTSD. IL1B rs1143633 C and rs16944 A minor allele frequencies and carriage rates are significantly lower in the PTSD patients as compared to the controls. The above-mentioned alleles can be protective against PTSD, and IL1B gene can be involved in the pathogenesis of this disorder. |
| Potential Biomarker |
None |
Genetic result reported by this study
Normal genetic result reported by this study (count: 5)
| Marker |
Phenotype |
Related Gene |
Statistical Values |
Author Comments |
Marker's Category |
|
rs1143643
|
PTSD diagnosis |
IL1B |
T carriage: OR=0.98, P-value=1, corrected P-value=1. |
No association between this SNP and PTSD was found.
No association between this SNP and PTSD was found.
|
Non-significant |
|
rs1143634
|
PTSD diagnosis |
IL1B |
G carriage: OR=0.80, P-value=0.38, corrected P-value=1 |
No association between this SNP and PTSD was found.
No association between this SNP and PTSD was found.
|
Non-significant |
|
rs1143633
|
PTSD diagnosis |
IL1B |
C carriage: OR=0.40, P-value=0.0002, corrected P-value=0.001 |
IL1B rs1143633 C minor allele frequency was significantly lo......
IL1B rs1143633 C minor allele frequency was significantly lower in PTSD patients than in controls. The carriers of this allele were underrepresented in patients compared to controls.
More...
|
Significant |
|
rs2853550
|
PTSD diagnosis |
IL1B |
A carriage: OR=0.71, P-value=0.17, corrected P-value=0.85 |
No association between this SNP and PTSD was found.
No association between this SNP and PTSD was found.
|
Non-significant |
|
rs16944
|
PTSD diagnosis |
IL1B |
A carriage: OR=0.44, P-value=0.0028, corrected P-value=0.014 |
IL1B rs16944 A minor allele frequency was also significantly......
IL1B rs16944 A minor allele frequency was also significantly lower in patients than in controls. The carriers of this allele were overrepresented in controls compared to patients.
More...
|
Significant |
